Maternal Age, Parity and Isolated Birth Defects: A Population-Based Case-Control Study in Shenzhen, China

Luo, Yuejun; Cheng, Y. S.; Gao, Xiao; Tan, Shu Qin; Li, Jian Mei; Wang, Wei; Chen, Qing

doi:10.1371/journal.pone.0081369

Cited by 47 publications

(46 citation statements)

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“…In the present study, we found no association between maternal age and clefts (p=0.747). A previous meta-analysis study 16 showed that the probability of mothers aged between 35 and 39 years having a child with cleft palate was 20% higher in comparison with those between 20 and 29 years old. For mothers aged 40 years or older, this probability was 28% higher compared to those aged between 20 and 29 years old.…”

Section: Resultsmentioning

confidence: 96%

“…To understand the developmental mechanisms underlying NSCL/P, it is essential to review a large and varied field of research 14 . The environmental risk factors for NSCL/P include maternal use of medications such as antiepileptic agents or corticosteroids, smoking and alcohol consumption during pregnancy 15 , intrapartum interval 10 , parity 16 , folic acid deficiencies 17 and maternal and paternal age 5 . However, there is no consensus on the association of parental age and NSCL/P 18 .…”

Section: Introductionmentioning

confidence: 99%

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Parental age is related to the occurrence of cleft lip and palate in Brazilian populations

et al. 2017

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Aim: To evaluate the association of environmental risk factors, particularly paternal and maternal age, with gender and type of oral cleft in newborn with nonsyndromic cleft lip with or without cleft palate (NSCL/P). Methods: This study included 1,346 children with NSCL/P of two Brazilian Services for treatment of craniofacial deformities. Parental ages were classified into the following groups: maternal age <35, 36-39, and ≥40 years; paternal age <39 and ≥40 years. The data was analyzed with chi-square test and multinomial logistic regression analysis. The odds ratios were estimated with a 95% confidence interval. Results: Of the 1,346 children included in this study, CLP was the type of NSCL/P with highest prevalence, followed by, respectively, CL and CP. There was a greater occurrence of NSCL/P in males compared to females (55.8% versus 44.2%). CLP was more common in men, while the CL and CP were more prevalent in women (p=0.000). No association between maternal age and clefts was observed (p=0.747). However, there was evidence of association between father's aged ≥40 years old and NSCL/P (p=0.031). When patients with CP were analyzed separately, no association between the father's age and the child's gender (p=0.728) was observed, i.e. the female gender prevails among patients with CP, regardless of the father's age. Conclusions: This study showed that there were differences in the distribution of the non-syndromic cleft lip and/ or palate and the gender, and fathers aged ≥40 years old may have increased risk of oral cleft. Further studies involving different populations are needed for a better understanding of the effect of maternal and paternal ages as a risk factor for the occurrence of oral clefts.

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Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Parental age is related to the occurrence of cleft lip and palate in Brazilian populations

et al. 2017

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“…Simultaneously, twin and multi-fetal infants were positively associated with the increased risk of congenital heart disease. It was commonly considered that an excessive number of parturitions may lead to reproductive organ damage and dysfunction and increase the risk of CHD [24]. Further studies will be required to corroborate these findings and, if confirmed, to elucidate possible reasons for these associations.…”

Section: Discussionmentioning

confidence: 96%

Prevalence and risk factors of congenital heart defects among live births: a population-based cross-sectional survey in Shaanxi province, Northwestern China

et al. 2017

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BackgroundNearly half of the population of Northwest China live in Shaanxi province, but population-based data on the epidemiologic characteristics of congenital heart defects (CHD) in this population is limited. The study aimed to investigate the prevalence and epidemiologic characteristics of the CHD among infants born between 2010 and 2013 in Shaanxi province.MethodsInfants born between 2010 and 2013 in Shaanxi province were surveyed using a stratified multi-stage sampling method. Participant characteristics were recorded by questionnaire, medical records were reviewed and CHD was diagnosed using a specialized neonatal echocardiography. A Poisson regression model was applied to assess the association between any CHD and possible risk factors.ResultsA total of 29098 live infants were surveyed with an overall prevalence of 76.0 (95% CI: 66.3, 86.7) per 10000 live infants. The prevalence of major and minor CHD were 26.1 and 49.8 per 10000 live infants, respectively, in surveyed areas. Poisson regression analysis indicated that, compared with singleton infants, the prevalence rate ratio of CHD was higher in twin and multi-fetal infants (PRR:3.1, 95% CI:1.6, 6.1). Using southern Shaanxi as a reference, the PRR of CHD were lower in northern (PRR:0.4, 95% CI:0.3, 0.6) and central Shaanxi province (PRR:0.5, 95% CI:0.4, 0.7). PRR was higher in mothers over 30 years of age than in those under 25 years (PRR:1.6, 95% CI:1.0, 2.5), and in mothers with ≥3 parity than that in mothers with only one parity (PRR:2.2, 95% CI:1.2, 4.2). The risk for CHD among live infants was positively associated with family history of CHD (PRR: 9.8, 95% CI: 5.3, 18.1). Additionally, CHD was less common in the floating population than the permanent population (PRR: 0.6, 95% CI: 0.4, 0.9).ConclusionThe CHD among live infants seemed to be a serious health problem in Shaanxi province as well as in Northwestern China. Our research have important policy implications for recommendations on CHD intervention in Northwest China.Electronic supplementary materialThe online version of this article (doi:10.1186/s12887-017-0784-1) contains supplementary material, which is available to authorized users.

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“…The proportion of mothers over 35 years of age at the time of delivery in Murmansk County was 5.7%, while it was 16.7% in Norway [10]. Advanced maternal age is significantly associated with an increased risk for a variety of birth defects [26], including those of the heart and Down syndrome [27]. In our study, the prevalence of these two defects was lower in Murmansk County than in Norway, which likely reflects the lower average maternal age observed in Murmansk County.…”

Section: Discussionmentioning

confidence: 99%

Under-reporting of major birth defects in Northwest Russia: a registry-based study

Kovalenko

Brenn

Odland

et al. 2017

International Journal of Circumpolar Health

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The objective was to assess the prevalence of selected major birth defects, based on data from two medical registries in Murmansk County, and compare the observed rates with those available for Norway and Arkhangelsk County, Northwest Russia. It included all newborns (≥22 completed weeks of gestation) registered in the Murmansk County Birth Registry (MCBR) and born between 1 January 2006 and 31 December 2009 (n=35,417). The infants were followed-up post-partum for 2 years through direct linkage to the Murmansk Regional Congenital Defects Registry (MRCDR). Birth defects identified and confirmed in both registries constituted the “cases” and corresponded to one or more of the 21 birth defect types reportable to health authorities in Moscow. The overall prevalence of major birth defects recorded in the MRCDR was 50/10,000 before linkage and 77/10,000 after linkage with the MCBR. Routine under-reporting to the MRCDR of 40% cases was evident. This study demonstrates that birth registry data improved case ascertainment and official prevalence assessments and reduced the potential of under-reporting by physicians. The direct linkage of the two registries revealed that hypospadias cases were the most prevalent among the major birth defects in Murmansk County. A bbreviations: ICD-10, International Classification of Diseases, 10th revision; MCBR, Murmansk County Birth Registry; MRCDR, Murmansk Regional Congenital Defects Registry; MGC, Murmansk Genetics Center

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Maternal Age, Parity and Isolated Birth Defects: A Population-Based Case-Control Study in Shenzhen, China

Cited by 47 publications

References 20 publications

Parental age is related to the occurrence of cleft lip and palate in Brazilian populations

Parental age is related to the occurrence of cleft lip and palate in Brazilian populations

Prevalence and risk factors of congenital heart defects among live births: a population-based cross-sectional survey in Shaanxi province, Northwestern China

Under-reporting of major birth defects in Northwest Russia: a registry-based study

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