Maternal age at delivery, lung function and asthma in offspring: a population-based survey

Real, Francisco Gómez; Burgess, John A.; Villani, Simona; Dratva, Julia; Heinrich, Joachim; Janson, Christer; Jarvis, Déborah; Koplin, Jennifer J.; Leynaert, Bénédicte; Lodge, Caroline; Lærum, Birger Norderud; Matheson, Melanie C.; Norbäck, Dan; Omenaas, Ernst; Skulstad, Svein Magne; Sunyer, Jordi; Dharmage, Shyamali C.; Svanes, Cecilie

doi:10.1183/13993003.01611-2016

Cited by 18 publications

(25 citation statements)

References 42 publications

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“…Interestingly, we noted that a high maternal age at delivery was a protective factor for asthma in this study. Similar to our finding, one recently published large-scale study, investigating 10,692 adults from 13 European countries, reported that increasing maternal age at delivery was associated with increasing forced expiratory volume in 1 s (FEV 1 ) and a low incidence of asthma at age 25–55 years, and the inverse correlation between maternal age at delivery and incident asthma mainly existed in females [31]. Additionally, we speculated that environmental factors as the aforementioned discussion regarding sibling effect on asthma might also at least partly explain the inverse association between maternal age at delivery and incident childhood asthma.…”

Section: Discussionsupporting

confidence: 90%

Shared prenatal impacts among childhood asthma, allergic rhinitis and atopic dermatitis: a population-based study

Lin

Wang

Chen

et al. 2019

Allergy Asthma Clin Immunol

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Background Increasing prevalence of childhood allergic diseases including asthma is a global health concern, and we aimed to investigate prenatal risk factors for childhood asthma and to address the potential shared prenatal impacts among childhood asthma, allergic rhinitis (AR) and atopic dermatitis (AD). Methods We used two claim databases, including Taiwan Birth Cohort Study (TBCS) and National Health Insurance Research Database (NHIRD), to identify independent paired mother–child data (mother–child dyads) between 2006 and 2009. The association between prenatal factors and asthma was determined by calculating adjusted odds ratio (aOR) with 95% confidence interval (CI) using conditional logistic regression analysis. Results A total of 628,878 mother–child dyads were included, and 43,915 (6.98%) of children developed asthma prior to age 6. We found that male gender (aOR 1.50, 95% CI 1.47–1.53), maternal asthma (aOR 1.80, 95% CI 1.71–1.89), maternal AR (aOR 1.33, 95% CI 1.30–1.37), preterm birth (aOR 1.32, 95% CI 1.27–1.37), low birth weight (aOR 1.14, 95% CI 1.10–1.19) and cesarean section (aOR 1.10, 95% CI 1.08–1.13) were independent predictors for childhood asthma. A high urbanization level and a low number of older siblings were associated with asthma in a dose–response manner. Notably, we identified that the association between maternal asthma and childhood asthma (aOR 1.80, 95% CI 1.71–1.89) was stronger compared with those between maternal asthma and childhood AR (aOR 1.67, 95% CI 1.50–1.87) as well as childhood AD (aOR 1.31, 95% CI 1.22–1.40). Similarly, the association between maternal AR and childhood AR (aOR 1.62, 95% CI 1.53–1.72) was higher than those between maternal AR and childhood asthma (aOR 1.33, 95% CI 1.30–1.37) as well as childhood AD (aOR 1.35, 95% CI 1.31–1.40). Furthermore, the number of maternal allergic diseases was associated with the three childhood allergic diseases in a dose–response manner. Conclusions In conclusion, this population-based study provided evidence of prenatal impacts on childhood asthma and demonstrated the shared maternal impacts among childhood asthma, AR, and AD. These findings highlight the shared prenatal impacts among allergic diseases, and studies are warranted to address the pivotal pathway in allergic diseases.

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Section: Discussionsupporting

confidence: 90%

Shared prenatal impacts among childhood asthma, allergic rhinitis and atopic dermatitis: a population-based study

Lin

Wang

Chen

et al. 2019

Allergy Asthma Clin Immunol

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“…For example, in the present study, the time spent for outdoor exercise was significantly higher in males (7.9 ± 7.6 hours) than that in females (7.3 ± 7.9 hours), which, due to time‐activity patterns, may affect the lung function development. However, some other studies found that males were more vulnerable to environmental factors . Therefore, the effects of genders as a modifier on the association between home renovation exposure and lung function are still unclear, and further studies are required to determine the cause of such differences.…”

Section: Discussionmentioning

confidence: 97%

Impact on lung function among children exposed to home new surface materials: The seven Northeastern Cities Study in China

Gurram

Bloom

et al. 2019

Indoor Air

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We conducted a cross‐sectional study to investigate the associations between recent home renovation exposure and lung function in children. We randomly recruited 7326 school children residing in 24 districts from seven cities in northeastern China. We collected information about home renovations from parents using a questionnaire and lung function measurements from children using spirometer recordings gathered by trained professionals and expressed as the forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), maximal mid‐expiratory flow (MMEF), and peak expiratory flow (PEF). We identified higher odds of diminished lung function among these with home renovation in the previous 2 years compared to those without home renovation in the previous 2 years, for FVC (odds ratios [ORs] = 1.84 [95%CI: 1.58, 2.15]; FEV1: ORs = 2.82 [95%CI: 2.36, 3.36]; PEF: ORs = 1.51 [95%CI: 1.24, 1.83]; and MMEF: ORs = 1.90 [95%CI: 1.60, 2.24]). The associations were stronger among children exposed to new polyvinyl chloride (PVC) flooring compared to children exposed to other surface materials. Our results were consistent throughout the analysis of each type of renovation materials. In conclusion, recent home renovation exposure was associated with poor lung function among children. Strategies to protect home owners and their families from respiratory hazards during and after renovation are required.

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“…As for immune-mediated diseases, previous studies have indicated associations with increasing maternal age at delivery with an increased risk for type 1 diabetes [13] and food allergies [14] in the offspring. A fine-tuned balance between genetic, immunological, metabolic, and hormonal factors is necessary for reproduction, and all of these factors are likely involved in the aging process [15]. Therefore, maternal aging may affect health outcomes in offspring, including with regard to the development of their immune response.…”

Section: Discussionmentioning

confidence: 99%

Association between maternal age and outcomes in Kawasaki disease patients

et al. 2019

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Background The etiology of Kawasaki disease (KD) is still unknown; perinatal factors may have role with few studies. This study was aim to survey the perinatal factors and clinical outcome of KD, including coronary artery lesion (CAL) formation and intravenous immunoglobulin (IVIG) treatment response. Methods We enrolled a total of 185 KD patient–caregiver dyads in this study using questionnaires. The questionnaire included two categories: children’s characteristics, which consisted of age at disease onset, gender, gestational age at delivery, birth body weight, delivery methods, and breastfeeding status, and caregivers’ characteristics, which consisted of parents or not, education levels, maternal age at giving birth, total number of offspring, and family income. We analyzed the association of these factors with CAL formation and IVIG treatment response of KD. Results KD patients with CAL formation had a higher maternal age than non-CAL patients (32.49 ± 3.42 vs. 31.01 ± 3.92 years, p = 0.016). We also found that maternal age ≥ 32 years group had a higher rate of having KD patients with CAL (39/81 vs. 24/74, odds ratio 1.935, 95% confidence interval [1.007, 3.718], p = 0.047). The maternal age ≥ 35 years group had a higher rate of having KD patients with IVIG resistance (6/31 vs. 6/116, odds ratio 4.400, 95% confidence interval [1.309, 14.786], p = 0.01). There was no significant difference in either CAL formation or IVIG resistance in KD with regard to patient’s age at disease onset, gestational age, birth body weight, delivery methods, breastfeeding, caregiver type, caregivers’ education level, total number of offspring, or family income ( p > 0.05). Conclusions This study is the first to report that maternal age is significantly associated with CAL formation and IVIG resistance in KD. We hypothesize that a maternal age less than 32 years would benefit KD offspring.

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Maternal age at delivery, lung function and asthma in offspring: a population-based survey

Cited by 18 publications

References 42 publications

Shared prenatal impacts among childhood asthma, allergic rhinitis and atopic dermatitis: a population-based study

Shared prenatal impacts among childhood asthma, allergic rhinitis and atopic dermatitis: a population-based study

Impact on lung function among children exposed to home new surface materials: The seven Northeastern Cities Study in China

Association between maternal age and outcomes in Kawasaki disease patients

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