Maternal age and asthma in Latino populations

Abid, Zabihullah; Oh, Sam S.; Hu, Donglei; Sen, Sáunak; Huntsman, Scott; Eng, Celeste; Farber, Harold J.; Rodríguez-Cintrón, William; Rodríguez‐Santana, José; Serebrisky, Denise; Avila, Pedro C.; Thyne, Shannon; Kim, K. Y.A.; Borrell, Luisa N.; Williams, L. Keoki; Seibold, Max A.; Burchard, Esteban G.; Kumar, Rajesh

doi:10.1111/cea.12765

Cited by 8 publications

(5 citation statements)

References 39 publications

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“…In a case-control study in the U.S., maternal age over 30 years at delivery was an independent predictor of food allergy in their children. 13 Several studies have shown associations between maternal age at delivery and risk of asthma in offspring; however, this relationship was inconsistent across different countries, [14][15][16][17] suggesting that there may be ethnic differences in the relationship between maternal age at delivery and development of allergic diseases in offspring. To date, the relationship between maternal age at delivery and the development of childhood allergic rhinitis has not been fully explored.…”

Section: Introductionmentioning

confidence: 99%

Association between maternal age at delivery and allergic rhinitis in schoolchildren: A population-based study

Chiu

Kao

et al. 2020

World Allergy Organization Journal

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Background: Some studies have shown associations of maternal age at delivery with asthma and food allergy in offspring. However, the relationship between maternal age at delivery and allergic rhinitis is largely unclear. This study aimed to investigate the association between maternal age at delivery and allergic rhinitis in a population sample of Asian children, and to explore potential effect modifiers.Methods: A total of 1344 singleton-birth children (763 boys, 56.8%; mean age, 6.4 years) participating in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort were evaluated by a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and interviewed by pediatricians. Allergic sensitization was determined by using Phadiatop Infant. Multiple logistic regression models with covariates adjustment were performed to investigate the association of maternal age at delivery with allergic rhinitis and allergic sensitization in offspring.Results: Among 1344 study children, 793 (59%) had physician-diagnosed allergic rhinitis.Advanced maternal age at delivery (!40 years) was significantly associated with increased odds of allergic rhinitis (adjusted odds ratio [AOR] ¼ 4.58, 95% confidence interval [CI]: 1.90-11.03) and allergic sensitization (AOR ¼ 2.86, 95% CI: 1.13-7.22) in offspring. A sex-stratified analysis revealed that the association of advanced maternal age with allergic rhinitis was statistically significant only in female offspring (AOR ¼ 7.02, 95% CI: 1.89-26.14). Stratified analyses by birth order or environmental tobacco smoke exposure during pregnancy did not reveal any significant differences. Conclusion:Advanced maternal age at delivery was associated with increased risk of allergic rhinitis in Asian children, probably more pronounced among girls.

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Section: Introductionmentioning

confidence: 99%

Association between maternal age at delivery and allergic rhinitis in schoolchildren: A population-based study

Chiu

Kao

et al. 2020

World Allergy Organization Journal

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“…[10][11][12][13][14][15][16] The role of maternal age at delivery in the development of asthma and allergy in the offspring is however uncertain: while some studies have shown that child birth at a young age is a risk factor for the development of asthma and allergy in the offspring, other studies have reported that old age at delivery is a risk factor, yet some studies found no relationship between mother's age at birth and offspring's asthma and allergy. [17][18][19] Although the specific mechanism through which maternal age at delivery influences the offspring's risk of developing asthma and allergy has not been elucidated, it has been suggested that this may involve a combination of hormonal, metabolic, immunological and genetic factors, which manifest during the fine-tuning of the processes of reproduction. 18 Clarifying the impact of maternal age at delivery on offspring's risk of developing asthma and allergy will contribute to ongoing evidence of the importance of reproductive events in later health of the child.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Maternal age at delivery and risk of allergy and asthma in the offspring: a systematic review and meta-analysis protocol

et al. 2020

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IntroductionWhile several perinatal factors have been linked to the risk of developing asthma and allergy in childhood, the role of maternal age at delivery remains uncertain. Some studies suggest that young maternal age at delivery may increase the risk, while other studies suggested a reduced risk. To provide a clearer appreciation of the underlying evidence, we plan to undertake a systematic review to synthesise previous studies that have investigated the association between maternal age at delivery and the risk of asthma and allergy in the offspring.Methods and analysisWe will search PubMed, EMBASE, ISI Web of Science, Scopus and Google Scholar to identify relevant studies on the topic published in the databases from inception until October 2020. We will search databases of proceedings of international conferences, contact authors who have published on the topic and search the reference lists of the included studies in order to identify additional studies. Two investigators will independently screen the identified studies, perform data extraction and examine the risk of bias in the studies; a third investigator will arbitrate throughout these processes. We will use the Effective Public Health Practice Project tool for assessment of the risk of bias in included studies. We will perform random-effects meta-analysis to combine effect estimates from included studies judged to be homogeneous.Ethics and disseminationOnly data from the published literature will be included in this study, therefore no ethics approval is required. Our findings will be published in a peer-reviewed journal.Protocol registrationThe protocol has been submitted for registration on PROSPERO, University of York, and Centre for Review and Dissemination, now awaiting the assignment of a registration number.

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“…Informed by previous studies, age, 6 maternal age at birth, 42 sex, 43 socioeconomic status, 33,44 environmental exposures, [45][46][47][48][49] birth weight, 50,51 and global genetic ancestry 38,52 were considered potential confounders in the analyses. The socioeconomic indicators included were maternal educational attainment and insurance status.…”

Section: Covariate Selectionmentioning

confidence: 99%

Acculturation is associated with asthma burden and pulmonary function in Latino youth: The GALA II study

Thakur

Borrell

et al. 2019

Journal of Allergy and Clinical Immunology

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Background: Acculturation is an important predictor of asthma in Latino youth, specifically Mexican Americans. Less is known about acculturation and pulmonary function measures. Objective: We sought to estimate the association of acculturation measures with asthma and pulmonary function in Latino youth and determine whether this association varies across Latino subgroups. Methods: We included 1849 Latinos (302 Caribbean Spanish, 193 Central or South Americans, 1136 Mexican Americans, and 218 other Latino children) aged 8 to 21 years from 4 urban regions in the United States. Acculturation measures include nativity status, age of immigration, language of preference, and generation in the United States. We used multivariable logistic and linear regression models to quantify the association of acculturation factors with the presence of asthma (case-control study) and pulmonary function (case-only study), adjusting for demographic, socioenvironmental, and clinical variables. Results: For all acculturation measures (nativity status, age of immigration, language of preference, and generation in the United States), greater levels of acculturation were associated with greater odds of asthma. Among cases, high (English preference) and medium (equal preference for Spanish and English) levels of language acculturation were associated with decreased bronchodilator response compared with low (Spanish preference) levels (P 5 .009 and .02, respectively). Similarly, high language acculturation was associated with increased FEV 1 compared with low language acculturation (P 5 .02). There was insufficient evidence of heterogeneity for associations across Latino subgroups. Conclusions: Acculturation was associated with diagnosed asthma and pulmonary function in Latino children and is an important factor to consider in the management of Latino youth with asthma.

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Maternal age and asthma in Latino populations

Cited by 8 publications

References 39 publications

Association between maternal age at delivery and allergic rhinitis in schoolchildren: A population-based study

Association between maternal age at delivery and allergic rhinitis in schoolchildren: A population-based study

Maternal age at delivery and risk of allergy and asthma in the offspring: a systematic review and meta-analysis protocol

Acculturation is associated with asthma burden and pulmonary function in Latino youth: The GALA II study

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