2023
DOI: 10.1590/s1678-9946202365046
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Maternal A90V mutation in the PreS1 gene of sub-genotype C2 hepatitis B virus is associated with intrauterine transmission

Linzhu Yi,
Jiaxin Wu,
Zhiqing Yang
et al.

Abstract: PreS/S gene mutations could impact virus secretion, infection and immune evasion. However, the relationship between PreS/S mutations and intrauterine transmission has not yet been clarified. Thus, we aimed to explore the associations between PreS/S gene mutations of HBV isolated from mothers and intrauterine transmission. We analyzed the mutations of PreS/S regions of the HBV genome in mothers with HBV DNA levels ≥ 10 6 IU/mL whose neonates experienced HBV intrauterine transmission (tran… Show more

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