Materials Science and Design Principles of Growth Factor Delivery Systems in Tissue Engineering and Regenerative Medicine

Subbiah, Ramesh; Guldberg, Robert E.

doi:10.1002/adhm.201801000

Cited by 137 publications

(112 citation statements)

References 245 publications

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“…[ 21,47,127 ] Additionally, some researchers make use of the biodegradability of hydrogels such as alginate, chitosan, PEG and fibrin for optimal release kinetics in physical conditions. [ 128,129 ] Below is a detailed summary of several types of stimuli‐responsive GF delivery strategies for the treatment of muscular disease.…”

Section: Stimuli‐responsive Growth Factor Delivery Systems In Tissuementioning

confidence: 99%

“…[ 136 ] Alginate, due to its calcium ion‐dependent crosslinking and degradation, is an ideal hydrogel considering that the physiological calcium concentration is optimal for its slow decomposition. [ 128 ] Based on this property, researchers can design systems using calcium ion‐responsive materials to sustain release of GFs for muscle regeneration. Mooney and co‐workers compared alginate‐mediated IGF‐1 and VEGF delivery with bolus delivery for muscle regeneration.…”

Section: Stimuli‐responsive Growth Factor Delivery Systems In Tissuementioning

confidence: 99%

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Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

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Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half‐life within the physiological microenvironment and significant side effects caused by off‐target effects or improper dosage. “Smart” materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on‐demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these “smart” materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease‐specific stimuli. The aim of this review is to summarize the current research on stimuli‐responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such “smart” materials and perspectives on future applications of stimuli‐responsive GF delivery for tissue regeneration are also discussed.

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Section: Stimuli‐responsive Growth Factor Delivery Systems In Tissuementioning

confidence: 99%

Section: Stimuli‐responsive Growth Factor Delivery Systems In Tissuementioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

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“…To achieve the goal of axonal regeneration, numerous studies have employed GF loading into neural scaffolds/conduits to enhance the speed and accuracy of injured nerve restoration [ 17 ]. For instance, glial-derived neurotrophic factor (GDNF) supplementation of multiluminal conduits had a beneficial effect on inducing axon outgrowth and target reinnervation compared to GDNF-free conduits in a 4 cm nerve gap injury [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration

et al. 2020

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Peripheral nerve injury (PNI), one of the most common concerns following trauma, can result in a significant loss of sensory or motor function. Restoration of the injured nerves requires a complex cellular and molecular response to rebuild the functional axons so that they can accurately connect with their original targets. However, there is no optimized therapy for complete recovery after PNI. Supplementation with exogenous growth factors (GFs) is an emerging and versatile therapeutic strategy for promoting nerve regeneration and functional recovery. GFs activate the downstream targets of various signaling cascades through binding with their corresponding receptors to exert their multiple effects on neurorestoration and tissue regeneration. However, the simple administration of GFs is insufficient for reconstructing PNI due to their short half-life and rapid deactivation in body fluids. To overcome these shortcomings, several nerve conduits derived from biological tissue or synthetic materials have been developed. Their good biocompatibility and biofunctionality made them a suitable vehicle for the delivery of multiple GFs to support peripheral nerve regeneration. After repairing nerve defects, the controlled release of GFs from the conduit structures is able to continuously improve axonal regeneration and functional outcome. Thus, therapies with growth factor (GF) delivery systems have received increasing attention in recent years. Here, we mainly review the therapeutic capacity of GFs and their incorporation into nerve guides for repairing PNI. In addition, the possible receptors and signaling mechanisms of the GF family exerting their biological effects are also emphasized.

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“…The ability to design such scaffolds with hollow features enables loading of cargo with different compositions in controllable arrangements, as to fabricate scaffolds with spatially defined instructive cues. As a proof of principle, we employed 3D‐printed microcages loaded with microscale granular hydrogels (microgels) [ 7 ] supplemented with growth factors of varying compositions, [ 8 ] which show enhanced cell invasion into the core of assembled constructs in a controllable manner, thus accelerating the process of new tissue formation and healing.…”

Section: Figurementioning

confidence: 99%

3D Printing of Microgel‐Loaded Modular Microcages as Instructive Scaffolds for Tissue Engineering

et al. 2020

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Biomaterial scaffolds have served as the foundation of tissue engineering and regenerative medicine. However, scaffold systems are often difficult to scale in size or shape in order to fit defect‐specific dimensions, and thus provide only limited spatiotemporal control of therapeutic delivery and host tissue responses. Here, a lithography‐based 3D printing strategy is used to fabricate a novel miniaturized modular microcage scaffold system, which can be assembled and scaled manually with ease. Scalability is based on an intuitive concept of stacking modules, like conventional toy interlocking plastic blocks, allowing for literally thousands of potential geometric configurations, and without the need for specialized equipment. Moreover, the modular hollow‐microcage design allows each unit to be loaded with biologic cargo of different compositions, thus enabling controllable and easy patterning of therapeutics within the material in 3D. In summary, the concept of miniaturized microcage designs with such straight‐forward assembly and scalability, as well as controllable loading properties, is a flexible platform that can be extended to a wide range of materials for improved biological performance.

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Materials Science and Design Principles of Growth Factor Delivery Systems in Tissue Engineering and Regenerative Medicine

Cited by 137 publications

References 245 publications

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration

3D Printing of Microgel‐Loaded Modular Microcages as Instructive Scaffolds for Tissue Engineering

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