Material Couture for Wound Healing and Regeneration: an Overview

Kaur, Indu Pal; Sandhu, Simarjot Kaur; Deol, Parneet Kaur; Sharma, Gaurav; Yadav, Monika; Singh, Mandeep

doi:10.2174/1381612821666150115125717

Cited by 10 publications

(6 citation statements)

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“…Thermoplastic polyurethane (TPU) is a biocompatible and biodegradable elastomer that has been approved by the FDA, and has been widely applied in biomedical science [ 9 , 10 ]. It has been reported that TPU can be used for catheters, vascular grafts and drug delivery carriers [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing

Liu

Chen

et al. 2018

J Nanobiotechnol

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BackgroundDeveloping an ideal wound dressing that meets the multiple demands of good biocompatibility, an appropriate porous structure, superior mechanical property and excellent antibacterial activity against drug-resistant bacteria is highly desirable for clinical wound care. Biocompatible thermoplastic polyurethane (TPU) membranes are promising candidates as a scaffold; however, their lack of a suitable porous structure and antibacterial activity has limited their application. Antibiotics are generally used for preventing bacterial infections, but the global emergence of drug-resistant bacteria continues to cause social concerns.ResultsConsequently, we prepared a flexible dressing based on a TPU membrane with a specific porous structure and then modified it with a biomimetic polydopamine coating to prepare in situ a nano-silver (NS)-based composite via a facile and eco-friendly approach. SEM images showed that the TPU/NS membranes were characterized by an ideal porous structure (pore size: ~ 85 μm, porosity: ~ 65%) that was decorated with nano-silver particles. ATR-FITR and XRD spectroscopy further confirmed the stepwise deposition of polydopamine and nano-silver. Water contact angle measurement indicated improved surface hydrophilicity after coating with polydopamine. Tensile testing demonstrated that the TPU/NS membranes had an acceptable mechanical strength and excellent flexibility. Subsequently, bacterial suspension assay, plate counting methods and Live/Dead staining assays demonstrated that the optimized TPU/NS2.5 membranes possessed excellent antibacterial activity against P. aeruginosa, E. coli, S. aureus and MRSA bacteria, while CCK8 testing, SEM observations and cell apoptosis assays demonstrated that they had no measurable cytotoxicity toward mammalian cells. Moreover, a steady and safe silver-releasing profile recorded by ICP-MS confirmed these results. Finally, by using a bacteria-infected (MRSA or P. aeruginosa) murine wound model, we found that TPU/NS2.5 membranes could prevent in vivo bacterial infections and promote wound healing via accelerating the re-epithelialization process, and these membranes had no obvious toxicity toward normal tissues.ConclusionBased on these results, the TPU/NS2.5 nanocomposite has great potential for the management of wounds, particularly for wounds caused by drug-resistant bacteria.

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Section: Introductionmentioning

confidence: 99%

“…It has been reported that TPU can be used for catheters, vascular grafts and drug delivery carriers [ 11 – 13 ]. Moreover, TPU also exhibits remarkable chemical stability and good mechanical properties [ 10 , 12 ]. These superior performances indicate that TPU is a promising candidate for wound dressings.…”

Section: Introductionmentioning

confidence: 99%

Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing

Liu

Chen

et al. 2018

J Nanobiotechnol

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“…For wound dressing materials, natural and synthetic polymers are commonly used as the dressing material, in the form of films, hydrogels, and scaffolds [ 29 ]. Recently, natural materials have gained much attention in biomedical production because of their high biocompatibility and environmentally friendly properties [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Superior Technique for the Production of Agarose Dressing Containing Sericin and Its Wound Healing Property

Napavichayanun

Pienpinijtham

Reddy³

et al. 2021

Polymers

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Finding a simple and eco-friendly production technique that matches to the natural agent and results in a truly valuable natural scaffold production is still limited amongst the intensively competitive natural scaffold development. Therefore, the purpose of this study was to develop natural scaffolds that were environmentally friendly, low cost, and easily produced, using natural agents and a physical crosslinking technique. These scaffolds were prepared from agarose and sericin using the freeze-drying method (D) or freeze-thawing together with the freeze-drying method (TD). Moreover, plasticizers were added into the scaffold to improve their properties. Their physical, mechanical, and biological properties were investigated. The results showed that scaffolds that were prepared using the TD method had stronger bonding between sericin and other compounds, leading to a low swelling ratio and low protein release of the scaffolds. This property may be applied in the development of further material as a controlled drug release scaffold. Adding plasticizers, especially glycerin, into the scaffolds significantly increased elongation properties, leading to an increase in elasticity of the scaffold. Moreover, all scaffolds could activate cell migration, which had an advantage on wound healing acceleration. Accordingly, this study was successful in developing natural scaffolds using natural agents and simple and green crosslinking methods.

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“…Traditionally, various dressing materials such as grease, honey, and oil were used to cover wounds to prevent infection and/or reduce pain . A material that protects the wound while promoting wound healing is clinically advantageous . Thus, various such dressing materials have been developed and clinically applied .…”

Section: Introductionmentioning

confidence: 99%

“…1,2 A material that protects the wound while promoting wound healing is clinically advantageous. [3][4][5][6][7][8] Thus, various such dressing materials have been developed and clinically applied. 9 For example, collagen, an abundant extracellular matrix component, in combination with a thin silicone sheet is clinically applied to burns, traumas, and surgically operated wounds.…”

Section: Introductionmentioning

confidence: 99%