Material-based therapy for bone nonunion

Leng, Yangming; Yang, Fan; Wang, Qian; Li, Zuhao; Yuan, Baoming; Peng, Chuangang; Ren, Guangkai; Wang, Zhonghan; Cui, Yutao; Wang, Yanbing; Zhu, Lianjie; Li, He; Wu, Dankai

doi:10.1016/j.matdes.2019.108161

Cited by 26 publications

(21 citation statements)

References 199 publications

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“…However, there are limited studies on the use of hydrogels as cells or drug carriers to fill porous metal implants. In spite of BMSCs, exogenous BMP-2 and vascular endothelial growth factor were added into porous titanium scaffolds to promote long-term survival of titanium implants [50][51][52]. However, these studies were investigated in non-osteoporotic models or only to unilaterally promote bone regeneration without comprehensive consideration of the mechanical strength of scaffolds, degradation rate of hydrogels, release profile, and the microenvironment of low osteogenic capacity in osteoporosis.…”

Section: Mechanical Properties Of Bioactive Interface With Surrounding Bonementioning

confidence: 99%

Enhanced osseointegration of three-dimensional supramolecular bioactive interface through osteoporotic microenvironment regulation

Bai

Zhao²,

Wang

et al. 2020

Theranostics

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Purpose:Osteoporosis is more likely to cause serious complications after joint replacement, mainly due to physiological defects of endogenous osteogenic cells and the pathological osteoclast activity. It is a feasible solution to design a prosthetic surface interface that specifically addresses this troublesome situation. Methods: A novel "three-dimensional (3D) inorganic-organic supramolecular bioactive interface" was constructed consisting of stiff 3D printing porous metal scaffold and soft multifunctional, self-healable, injectable, and biodegradable supramolecular polysaccharide hydrogel. Apart from mimicking the bone extracellular matrix, the bioactive interface could also encapsulate bioactive substances, namely bone marrow mesenchymal stem cells (BMSCs) and bone morphogenetic protein-2 (BMP-2). A series of in vitro characterizations, such as topography and mechanical characterization, in vitro release of BMP-2, biocompatibility analysis, and osteogenic induction of BMSCs were carried out. After that, the in vivo osseointegration effect of the bioactive interface was investigated in detail using an osteoporotic model. Results:The administration of injectable supramolecular hydrogel into the inner pores of 3D printing porous metal scaffold could obviously change the morphology of BMSCs and facilitate its cell proliferation. Meanwhile, BMP-2 was capable of being sustained released from supramolecular hydrogel, and subsequently induced osteogenic differentiation of BMSCs and promoted the integration of the metal microspores-bone interface in vitro and in vivo. Moreover, the osteoporosis condition of bone around the bioactive interface was significantly ameliorated. Conclusion:This study demonstrates that the 3D inorganic-organic supramolecular bioactive interface can serve as a novel artificial prosthesis interface for various osteogenesis-deficient patients, such as osteoporosis and rheumatoid arthritis.

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Section: Mechanical Properties Of Bioactive Interface With Surrounding Bonementioning

confidence: 99%

Enhanced osseointegration of three-dimensional supramolecular bioactive interface through osteoporotic microenvironment regulation

Bai

Zhao²,

Wang

et al. 2020

Theranostics

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“…The most commonly used synthetic polymers for periosteum development include polylactic(L-lactic-co-glycolic acid), polyurethanes, poly(ethylene glycol), polycaprolactone and poly(L-lactic acid) [18][19][20][21][22]. However, these synthetic materials also have some disadvantages: they can induce host tissue response and foreign body reactions during degradation (by non-enzymatic hydrolysis), and moderate cytotoxic reactions may reduce cellular adhesion [23].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Silk Fibroin/Sericin Composite Film: Preparation, Mechanical Properties and Mineralization Activity

Tian

Zhang

et al. 2022

Polymers

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The periosteum plays an important role in bone formation and reconstruction. One of the reasons for the high failure rate of bone transplantation is the absence of the periosteum. Silk fibroin (SF) and silk sericin (SS) have excellent biocompatibility and physicochemical properties, which have amazing application prospects in bone tissue engineering, but lacked mechanical properties. We developed a series of SF/SS composite films with improved mechanical properties using boiling water degumming, which caused little damage to SF molecular chains to retain larger molecules. The Fourier transform infrared spectroscopy and X-ray diffraction results showed that there were more β-sheets in SF/SS films than in Na2CO3 degummed SF film, resulting in significantly improved breaking strength and toughness of the composite films, which were increased by approximately 1.3 and 1.7 times, respectively. The mineralization results showed that the hydroxyapatite (HAp) deposition rate on SF/SS composite films was faster than that on SF film. The SF/SS composite films effectively regulated the nucleation, growth and aggregation of HAp-like minerals, and the presence of SS accelerated the early mineralization of SF-based materials. These composite films may be promising biomaterials in the repair and regeneration of periosteum.

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“…Natural bone healing is a well-orchestrated process that involves multiple physiological events, including acute inflammation, recruitment of mesenchymal stem cells (MSCs) to generate a primary cartilaginous callus, revascularization and calcification, and bone remodeling [ [1] , [2] , [3] , [4] ]. Despite the self-healing capacity of bone tissue, delayed union or non-union formations were caused by tumor resection, trauma, infection, and skeletal abnormalities [ [5] , [6] , [7] ]. Among all these processes, angiogenesis plays a crucial role in bone regeneration because the bone is a highly vascularized tissue.…”

Section: Introductionmentioning

confidence: 99%

Hypoxia-mimicking 3D bioglass-nanoclay scaffolds promote endogenous bone regeneration

Zheng

Zhang

Wang

et al. 2021

Bioactive Materials

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Large bone defect repair requires biomaterials that promote angiogenesis and osteogenesis. In present work, a nanoclay (Laponite, XLS)-functionalized 3D bioglass (BG) scaffold with hypoxia mimicking property was prepared by foam replication coupled with UV photopolymerization methods. Our data revealed that the incorporation of XLS can significantly promote the mechanical property of the scaffold and the osteogenic differentiation of human adipose mesenchymal stem cells (ADSCs) compared to the properties of the neat BG scaffold. Desferoxamine, a hypoxia mimicking agent, encourages bone regeneration via activating hypoxia-inducible factor-1 alpha (HIF-1α)-mediated angiogenesis. GelMA-DFO immobilization onto BG-XLS scaffold achieved sustained DFO release and inhibited DFO degradation. Furthermore, in vitro data demonstrated increased HIF-1α and vascular endothelial growth factor (VEGF) expressions on human adipose mesenchymal stem cells (ADSCs). Moreover, BG-XLS/GelMA-DFO scaffolds also significantly promoted the osteogenic differentiation of ADSCs. Most importantly, our in vivo data indicated BG-XLS/GelMA-DFO scaffolds strongly increased bone healing in a critical-sized mouse cranial bone defect model. Therefore, we developed a novel BG-XLS/GelMA-DFO scaffold which can not only induce the expression of VEGF, but also promote osteogenic differentiation of ADSCs to promote endogenous bone regeneration.

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Material-based therapy for bone nonunion

Cited by 26 publications

References 199 publications

Enhanced osseointegration of three-dimensional supramolecular bioactive interface through osteoporotic microenvironment regulation

Enhanced osseointegration of three-dimensional supramolecular bioactive interface through osteoporotic microenvironment regulation

Enhanced Silk Fibroin/Sericin Composite Film: Preparation, Mechanical Properties and Mineralization Activity

Hypoxia-mimicking 3D bioglass-nanoclay scaffolds promote endogenous bone regeneration

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