Abstract:Experimental studies of antimicrobial peptides as potential drugs having a pore-forming mechanism of action have attracted increasing interest for clinical applications due to their broad spectrum of activity. Here in a short report, we describe an experimental approach for testing potential drugs using rat liver mitochondria as model and pore-forming peptide mastoparan. We have used tightly coupled mitochondria and a sensitive oximetric cell to study activation of mitochondrial respiration by mastoparan and s… Show more
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