Mastocytic enterocolitis: Increase of mast cells in the gastrointestinal tract of patients with chronic diarrhea

Capannolo, Annalisa; Sollima, Laura; Marinucci, Alessandro; Coletti, Gino; Pasetti, Annalisa; Frieri, Giuseppe; Bassotti, Gabrio; Villanacci, Vincenzo; Latella, Giovanni

doi:10.1016/j.gastrohep.2016.05.005

Cited by 5 publications

(1 citation statement)

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“…Initial treatment consists of histamine H1 and H2 receptor blockers, such as cetirizine and famotidine respectively, that inhibit mast cell release and function. Alternatively, cromolyn sodium can be used to prevent mediator release from mast cells [ 17 ]. In patients with refractory symptoms despite the initial treatment, steroids such as oral budesonide and beclomethasone dipropionate have been shown to be beneficial by addressing mucosal inflammation [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Mastocytic Enterocolitis: An Overlooked Diagnosis for Unexplained Chronic Diarrhea in a Patient With Colon Polyps and a Family History of Colon Cancer

Hu¹,

Franco²,

Parikh³

et al. 2023

Cureus

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Chronic intractable diarrhea is a common presenting complaint that is often clinically worked up for a wide variety of diseases including inflammatory bowel disease, celiac disease, and hyperthyroidism. When lab results come back normal, patients are often diagnosed with irritable bowel disease-diarrheal subtype, overlooking the potential diagnosis of mastocytic enterocolitis. Mastocytic enterocolitis is an uncommon diagnosis where patients can benefit from mast cell stabilizers that directly target the underlying pathology. Given the broad differential diagnosis of nonspecific diarrhea presentation, a histopathological examination is warranted for definitive diagnosis. We hope to raise awareness of this potentially treatable disease that can be effectively managed with antihistamines. We describe the case of a 63-year-old male patient with a family history significant for colon cancer who presented with intractable diarrhea and was ultimately diagnosed with mastocytic enterocolitis by histopathology. His symptoms were relieved by antihistamine treatment.

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Section: Discussionmentioning

confidence: 99%