Abstract:1567
Microtubule-associated serine/threonine like kinase (MASTL kinase) was originally identified by genetic linkage as the probable mutant gene responsible for the platelet phenotype in a family with autosomal-dominant thrombocytopenia. MASTL kinase is the mammalian ortholog of Drosophila Greatwall kinase, which is required for cell cycle regulation. Affected members of the thrombocytopenic family carried a mutant MASTL kinase allele with a single nucleotide change that converted a glutamic aci… Show more
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