Mastite granulomateuse récidivante chez une jeune femme : rôle potentiel de « corynebacterium kroppenstedtii »

Kieffer, P.; Dukic, R.; Hueber, M.; Kieffer, C.; Bouhala, M.; Riegel, Philippe; Wilhelm, J.-M.

doi:10.1016/j.revmed.2006.03.033

Cited by 25 publications

(8 citation statements)

References 22 publications

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“…Although it was first described more than four decades, an etiology and pathophysiology of IGM is still unknown. Some literature described an association with contraceptive pills, lactation, hyperprolactinemia, smoking and Corynebacterium infection [ 2 , [18] , [19] , [20] , [21] ]. Higher severity and longer duration of disease in puerperal period was shown in one study [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Idiopathic granulomatous mastitis: A retrospective cohort study between 44 patients with different treatment modalities

Chirappapha

Thaweepworadej

Supsamutchai

et al. 2018

Annals of Medicine and Surgery

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BackgroundIdiopathic granulomatous mastitis (IGM) is an uncommon benign chronic inflammatory disease which can clinically and radiographically mimic abscess or breast cancer. Definitive diagnosis was made by histopathology and exclusion of an identifying etiology. Optimal treatment has not been yet established. The aim of this study was to report and describe the clinical signs, radiological findings, managements, clinical course, and clinical outcomes after treatment of IGM.MethodWe retrospectively studied IGM medical records of 44 patients in our institute collected from March 1990 to October 2016. The patient characteristics, clinical presentations, radiological findings, microbiological workups, tissue pathology, treatment modalities, outcomes, and follow-up data were reviewed and analyzed. The success rate, recurrence rate and time-to-healing were compared focusing on the treatment modalities to find the proper treatments for IGM patient.ResultsForty-four patients were diagnosed as IGM. The median follow-up time was 20.73 months ranging from 1.26 to 118.8 months while the median time of the diagnosis was 21 days ranging from 2 to 246 days. Due to the follow-up period, only thirty-nine patient data were used for the analysis. In the first setting, 30 patients were treated by surgery, 6 patients were treated by using steroid while other 3 patients were treated by other different treatments. Only 25 from 39 patients (64.10%) were cured by the first modality. The overall median time-to-healing was 84 days while the medians of time-to-healing treated by surgery, steroid and the rest were 75, 114.5, and 238 days respectively. The surgical treatment had the shortest time-to-healing but not statistically significant (p = 0.23). Thirteen patients out of twenty-five (52%) had wound complications after performing an excision. Lastly, five patients out of thirty-nine (12.82%) had recurrence.ConclusionIGM is an uncommon benign disease which is hardly distinguished from malignancy. There is not a significant difference among treatment modalities in term of time-to-healing and recurrence of disease. The result shows that surgery is outperformed by the shortest healing time. However, the surgical treatment must be chosen with careful due to high rate of wound complications. Multimodality treatment is recommended as the proper treatments for IGM patient.

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Section: Discussionmentioning

confidence: 99%

Idiopathic granulomatous mastitis: A retrospective cohort study between 44 patients with different treatment modalities

Chirappapha

Thaweepworadej

Supsamutchai

et al. 2018

Annals of Medicine and Surgery

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“…Since the description of the clinical isolate from Sweden, which was used to characterize this new corynebacterial species taxonomically, additional isolates of this organism from human clinical sources have been reported in New Zealand [5], [6], France [7], [8], [9], [10], Canada [11], India [12], Japan [13], [14], [15] and Germany [16]. Eighty-eight percent of isolates have been obtained from women's breasts; the rest of the isolates came from sputum [1], [11], lung biopsy sample [11], blood [11] and endocardiac valve [16].…”

Section: Introductionmentioning

confidence: 99%

Characterization and antimicrobial susceptibility of one antibiotic-sensitive and one multidrug-resistant Corynebacterium kroppenstedtii strain isolated from patients with granulomatous mastitis

Fernández-Natal

Rodrı́guez-Lázaro

Marrodan-Ciordia

et al. 2016

New Microbes and New Infections

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Human infections associated with Corynebacterium kroppenstedtii are rarely reported, and this organism is usually described as antibiotic sensitive. Almost all published cases of C. kroppenstedtii infections have been associated with breast pathology in women and have been described in New Zealand, France, Canada, India and Japan. Here we describe the microbiologic characteristics of two strains isolated from two women diagnosed of granulomatous mastitis in Spain. One C. kroppenstedtii isolate was antibiotic sensitive while the other was multidrug resistant. Biochemical identification was possible using a wide battery of methods including API Coryne V2.0, API Strep, API NH, API NE, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene amplification and sequencing. Antimicrobial susceptibility to 28 antibiotics as determined by Etest showed one isolate being sensitive to benzylpenicillin, ciprofloxacin, moxifloxacin, gentamicin, vancomycin, clindamycin, tetracycline, linezolid and rifampin. The second isolate showed resistance to ciprofloxacin, moxifloxacin, clindamycin, tetracycline and rifampin. The multidrug-resistant isolate contained the erm(X), tet(W), cmx, aphA1-IAB, strAB and sul1 resistance genes known from the R plasmid pJA144188 of Corynebacterium resistens. These genes were absent in the genome of the antibiotic-sensitive isolate. This report confirms the tropism of this microorganism for women's breasts and presents the first description of a multidrug-resistant C. kroppenstedtii strain.

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“…Data on 42 cases of C. kroppenstedtii isolations from human clinical samples are presented in Table 2. 9,[19][20][21][22][23][24][25]27,29,30,[33][34][35][36] The first clinical isolate, which was used for the species description, was obtained from the sputum of an 82-year-old female patient. 9 The patient's sex was known for 38 cases, and all isolates except one 33 were obtained from female patients.…”

Section: Clinical Reviewmentioning

confidence: 99%

“…Mammary granulomas have been associated with tuberculosis, sarcoidosis, fungal infections, and Wegener's granulomatosis, but since 2002 they have also been associated with infection by C. kroppenstedtii. The role of this organism as a cause or complicating factor of granulomatous mastitis has been demonstrated by several authors, 21,22,24,27,29,[34][35][36] but further clinical and histopathological studies are necessary to clarify its real role in this disease. In many cases, long courses of antibiotics with or without surgery have been necessary for cure.…”

Section: Future Perspectivesmentioning

confidence: 99%

A microbiological and clinical review on Corynebacterium kroppenstedtii

Tauch

Fernández-Natal

Soriano³

2016

International Journal of Infectious Diseases

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The genus Corynebacterium represents a taxon of Gram-positive bacteria with a high G+C content in the genomic DNA. Corynebacterium kroppenstedtii is an unusual member of this taxon as it lacks the characteristic mycolic acids in the cell envelope. Genome sequence analysis of the C. kroppenstedtii type strain has revealed a lipophilic (lipid-requiring) lifestyle and a remarkable repertoire of carbohydrate uptake and utilization systems. Clinical isolates of C. kroppenstedtii have been obtained almost exclusively from female patients and mainly from breast abscesses and cases of granulomatous mastitis. However, the role of C. kroppenstedtii in breast pathologies remains unclear. This review provides a comprehensive overview of the taxonomy, microbiology, and microbiological identification of C. kroppenstedtii, including polyphasic phenotypic approaches, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and the use of 16S rRNA gene sequencing. A clinical review presents reported cases, various antimicrobial treatments, antibiotic susceptibility assays, and antibiotic resistance genes detected during genome sequencing. C. kroppenstedtii must be considered a potential opportunistic human pathogen and should be identified accurately in clinical laboratories.

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Mastite granulomateuse récidivante chez une jeune femme : rôle potentiel de « corynebacterium kroppenstedtii »

Cited by 25 publications

References 22 publications

Idiopathic granulomatous mastitis: A retrospective cohort study between 44 patients with different treatment modalities

Idiopathic granulomatous mastitis: A retrospective cohort study between 44 patients with different treatment modalities

Characterization and antimicrobial susceptibility of one antibiotic-sensitive and one multidrug-resistant Corynebacterium kroppenstedtii strain isolated from patients with granulomatous mastitis

A microbiological and clinical review on Corynebacterium kroppenstedtii

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