Masticatory Apparatus of Albino Rats in Experimental Lathyrism

Reversibility of Lathyric Damage to the Periodontal Structures

“…The present study agreed with the earlier ones of Gardner, et al 3 and Krikos,et al 2 in showing marked injury to the dental tissues in lathyric animals exposed to the toxic agent for a two week period. When at this time the animals were returned to normal diets, repair occurred in all instances.…”

“…There were numerous areas of hy- alinization with palisading arrangement of the fibroblasts exactly as described by Gardner, et al 3 (Fig. 2A.…”

“…The severe damage to the teeth and their supporting structures has been mentioned by Carwell 1 and described in detail by Krikos, et al 2 and by Gardner, et al 3 Whether the injured dental tissues can recover when the animals are taken off their toxic diets has not been investigated. The purpose of this study was to determine whether the damage to teeth and periodontal structures is reversible.…”

The effect of beta‐aminoproprionitrile on the periodontal ligament

“…The classic histologic lesion which develops in the periodontal ligament within one to two weeks after the onset of B-APN administration is called the "lathyritic body." It is characterized by an aggregation or palisading of the PDL fibroblasts in rows bordering an acellular amorphous matrix (Sciaky & Ungar 1961, Barrington & Meyer 1966, Krikos, Beltram & Cohen 1965, Yoshikawa 1971, Sims 1977, Baden & Bouissou 1983, Krikos et al 1958, Gardener et al 1958. To our knowledge there have been no ultrastructural studies of the "lathyric body" and the associated fibroblasts.…”

The Effects of Various Levels of Sweet Peas (Lathyrus Odoratus) in the Diet, With and Without Dietary Supplements, on the Growth of the Mandibular Ramus and Articulation in Young Rats

“…The most important oral and cranial changes found in lathyrism are periosteal new bone formation, as voluminous exostoses at sites of muscle insertions to the mandible of rats, the most obvious being at the coronoid, condyloid, and angular processes (Gardner and co-workers, 9 Dasler,' 10 1 and Selye '2, 13). Other changes are gross bone deformities of the cranium and G A R D N E ER July- August, 1959 voluminous exostoses of the occipital bone (Gardner and associates9), increased ash content of incisors (Dasler"), deformation of the mandible of Amblystoma punctatum embryos (Levy and Goodman '4), hyalinization of the periodontal membrane (Carwell,'5 Gardner et al9), degenerative arthritis of the mandibular condyle (Gardner9) and proliferation of connective tissue (Gardner9).…”