Mastering gut permeability: New roles for old friends

Bramhall, Michael; Zaph, Colby

doi:10.1002/eji.201646842

Cited by 8 publications

(6 citation statements)

References 29 publications

(35 reference statements)

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“…(2010) and our current study was that we used two parasites that physically overlap in their infection site (duodenum), whereas H. bakeri (duodenum) and E. falciformis (caecum) do not physically overlap. This suggests that in the case of coinfection of parasites that share the same niche, there is potential for more direct interaction between diverging immune cell populations as well as for tissue structural effects due to disruption of epithelial tissue integrity by the helminths (Boyett and Hsieh, 2014; Bramhall and Zaph, 2017). Specifically, in the case of H. polygyrus , tissue damage can occur when larvae are emerging from the gut epithelium and/or when feeding in the lumen as adults, which can limit the pool of suitable epithelial cells available for E. hungaryensis to infect.…”

Section: Discussionmentioning

confidence: 99%

Parasitic nematodes simultaneously suppress and benefit from coccidian coinfection in their natural mouse host

et al. 2019

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Within-host interactions among coinfecting parasites are common and have important consequences for host health and disease dynamics. However, these within-host interactions have traditionally been studied in laboratory mouse models, which often exclude important variation and use unnatural host–parasite combinations. Conversely, the few wild studies of within-host interactions often lack knowledge of parasite exposure and infection history. Here we exposed laboratory-reared wood mice (Apodemus sylvaticus) that were derived from wild-caught animals to two naturally-occurring parasites (nematode: Heligmosomoides polygyrus, coccidia: Eimeria hungaryensis) to investigate the impact of coinfection on parasite infection dynamics, and to determine if the host immune response mediates this interaction. Coinfection led to delayed worm expulsion and prolonged egg shedding in H. polygyrus infections and lower peak E. hungaryensis oocyst burdens. By comparing antibody levels between wild and colony-housed mice, we also found that wild mice had elevated H. polygyrus-IgG1 titres even if currently uninfected with H. polygyrus. Using this unique wild-laboratory system, we demonstrate, for the first time, clear evidence for a reciprocal interaction between these intestinal parasites, and that there is a great discrepancy between antibody levels measured in the wild vs those measured under controlled laboratory conditions in relation to parasite infection and coinfection.

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Section: Discussionmentioning

confidence: 99%

Parasitic nematodes simultaneously suppress and benefit from coccidian coinfection in their natural mouse host

et al. 2019

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“…From the blood collected at 1.5 h post-challenge, we observed that mice treated with BLG-p(Man) had reduced levels of mMCPT-1 ( Figure 4 D), which is released by mucosal mast cells upon degranulation during allergic hypersensitivity responses. 33 , 34 IL-6 and IL-4 have been found to be elevated during anaphylaxis in patients with food allergies. 35 The mice treated with saline or free BLG also showed elevated IL-6 and IL-4 levels in the serum upon BLG challenge, but the mice treated with BLG-p(Man) did not ( Figure 4 D).…”

Section: Resultsmentioning

confidence: 99%

Glycosylation-modified antigens as a tolerance-inducing vaccine platform prevent anaphylaxis in a pre-clinical model of food allergy

Cao,

Maulloo,

Raczy

et al. 2024

Cell Reports Medicine

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“…Histamine and mMCPT-1 are released from degranulating mast cells upon allergen cross-linking of IgE and are reliable markers of anaphylaxis. mMCPT-1 is a chmyase expressed by intestinal mucosal mast cells; elevated concentrations of mMCPT-1 increase intestinal barrier permeability during allergic hypersensitivity responses 46 , 47 . While ButM very effectively reduced the allergic response to peanut exposure, free NaBut had no effect in protecting allergic mice from an anaphylactic response (Fig.…”

Section: Resultsmentioning

confidence: 99%

Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles

et al. 2022

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The microbiome modulates host immunity and aids the maintenance of tolerance in the gut, where microbial and food-derived antigens are abundant. Yet modern dietary factors and the excessive use of antibiotics have contributed to the rising incidence of food allergies, inflammatory bowel disease and other non-communicable chronic diseases associated with the depletion of beneficial taxa, including butyrate-producing Clostridia. Here we show that intragastrically delivered neutral and negatively charged polymeric micelles releasing butyrate in different regions of the intestinal tract restore barrier-protective responses in mouse models of colitis and of peanut allergy. Treatment with the butyrate-releasing micelles increased the abundance of butyrate-producing taxa in Clostridium cluster XIVa, protected mice from an anaphylactic reaction to a peanut challenge and reduced disease severity in a T-cell-transfer model of colitis. By restoring microbial and mucosal homoeostasis, butyrate-releasing micelles may function as an antigen-agnostic approach for the treatment of allergic and inflammatory diseases.

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Mastering gut permeability: New roles for old friends

Abstract: Mast cells are innate immune cells that respond rapidly to infection in barrier tissues

Cited by 8 publications

References 29 publications

Parasitic nematodes simultaneously suppress and benefit from coccidian coinfection in their natural mouse host

Parasitic nematodes simultaneously suppress and benefit from coccidian coinfection in their natural mouse host

Glycosylation-modified antigens as a tolerance-inducing vaccine platform prevent anaphylaxis in a pre-clinical model of food allergy

Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles

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