Mastectomy: the preferred treatment in young women?

Velde, C.J.H. Van de; Sprundel, T C van; Hage, J. van der; Vijver, Marc J. van de

doi:10.1016/s1359-6349(04)90639-8

Cited by 2 publications

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“…The indications for surgical treatment in young women do not differ from those in older women, VAN DE VELDE [23] and GENEVIEVE [24], compared radical surgery to conservative surgery in young women and found that not only the recurrence rate was three times lower in women treated with mastectomy, but that the survival rate was significantly higher in this category of patients. This is linked to unfavorable differences in stage and tumor biology in young women according to Matthews et al, [25]; but this should not lead to the exclusion of conservative surgery in this population.…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer in Young Women under 40 years: Epidemiological, Clinical, Therapeutic and Prognostic Aspects in the Oncology and Radiotherapy Department of Marrakech; About 318 Cases

Elouarzzazi¹,

Nimbuna²,

Elmatlini³

et al. 2019

SIJOG

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Introduction:Breast cancer in women, and especially in young women, represents a real public health issue given its frequency and severity. The objective of our study is to specify the epidemiological profile; anatomo-clinical; therapy and prognosis of breast cancer in young women. Methods: Descriptive retrospective study spread over a period of 5 years (2013)(2014)(2015)(2016)(2017), collecting all the patients followed for breast cancer aged 40 years or less, within the cancer department of CHU Med VI in Marrakech. Results: The average age was 34.2 years (19-40 years). The average age at puberty was 12 years old (9 and 16 years old). Nulliparity was noted in 22% of the cases. Clinically, the T classification in the cases specified was: T1 (n = 48), T2 (n = 128), T3 (n = 52), T4 (n = 42). Clinical lymph node involvement was found in 44% of the cases. Histologically, infiltrating ductal carcinoma was the most common (n = 283). SBR II grade was the most frequent with a rate of 66%, Thirty Fifty percent of all patients had an over-expression of HER2 , Sixtythree percent had lymph node invasion, including 42% with capsular rupture and 31% of patients were metastatic in appearance. Therapeutically, fifty patients had neo-adjuvant chemotherapy. The surgery was conservative in 66% of the cases. Adjuvant chemotherapy was sequential in 61% of the cases. 180 patients had adjuvant radiation therapy. Of the 96 patients with HER2 over expression, 82 received treatment with trastuzumab. Hormone therapy was prescribed in 156 patients or 49% of cases with expression of hormone receptors. In our series, the median follow-up was 8.1 months. The course was marked by a locoregional relapse in fifty-eight patients, and a metastatic relapse in sixty patients. Conclusion: Since screening in our country does not include young women, it would be interesting to reconsider its indications, especially given the growing frequency of this cancer in young women as well as its poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Breast Cancer in Young Women under 40 years: Epidemiological, Clinical, Therapeutic and Prognostic Aspects in the Oncology and Radiotherapy Department of Marrakech; About 318 Cases

Elouarzzazi¹,

Nimbuna²,

Elmatlini³

et al. 2019

SIJOG

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“…Young women have an overall higher risk of local recurrence than postmenopausal women, and this risk may be amplified by breast‐conserving treatment 8 . Surprisingly, there is some evidence to show that quality of life appears to be better 5 years after mastectomy than after breast conservation, so it has been suggested that mastectomy may be the better option for the treatment of primary breast cancer in very young women 9 .…”

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confidence: 99%

Access to breast‐conserving treatment: are surgeons responsible?

Furnival

2004

ANZ Journal of Surgery

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Mastectomy: the preferred treatment in young women?

Cited by 2 publications

References 0 publications

Breast Cancer in Young Women under 40 years: Epidemiological, Clinical, Therapeutic and Prognostic Aspects in the Oncology and Radiotherapy Department of Marrakech; About 318 Cases

Breast Cancer in Young Women under 40 years: Epidemiological, Clinical, Therapeutic and Prognostic Aspects in the Oncology and Radiotherapy Department of Marrakech; About 318 Cases

Access to breast‐conserving treatment: are surgeons responsible?

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