Mast Cells

Rao, Kavitha N.; Brown, Melissa A.

doi:10.1196/annals.1443.023

Cited by 211 publications

(93 citation statements)

References 195 publications

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“…However, it is crucial that the inflammation phase be brief. Indeed, rapid onset of cellular proliferation and differentiation is necessary for shortening the healing process (Rao, Brown, 2008). In the present study, A. sativum administration resulted in decreased IMCs infiltration and reduced ALP activity on day 7.…”

Section: Discussionmentioning

confidence: 60%

“…The role of mast cells in enhancing cellular proliferation during wound healing has been reported previously (Rao, Brown, 2008;Theoharides et al, 2012). Mast cells are known to secrete vascular growth factor (VGF), which stimulates endothelial cell proliferation; this, in turn, has been shown to upregulate neovascularization during the healing process (Younan et al, 2011).…”

Section: Discussionmentioning

confidence: 92%

“…The inflammatory phase is considered a key step for clearing cellular debris from the injured tissue, as well as an essential response to microbial infection (Rao, Brown, 2008;Theoharides et al, 2012). However, it is crucial that the inflammation phase be brief.…”

Section: Discussionmentioning

confidence: 99%

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Hydroethanolic Allium sativum extract accelerates excision wound healing: evidence for roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio

Farahpour

Hesaraki

Faraji

et al. 2017

Braz. J. Pharm. Sci.

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The present study was designed to evaluate the in vivo effect of Allium sativum (garlic) hydroalcoholic extract on wound healing in rats. For this purpose, 72 mature Wistar rats were divided into four groups (n=18/each) to receive no treatment, placebo, Cicalfate®, or 2% Allium sativum (AS) extract, administered topically to the wound area, for 21 days. Following the experimental period, tissue samples were dissected out and underwent to histopathological analyses. Fibroblasts, fibrocytes, mast cells, intra-cytoplasmic carbohydrate ratio, neovascularization, collagen deposition, and re-epithelialization were analyzed in all groups. Animals in the treated groups showed significant enhancement in fibroblast, fibrocyte, and mast-cell distribution. Significantly higher neovascularization was observed on day 3 after wound induction in AS-treated animals versus those in the placebo, Cicalfate, and untreated groups (P<0.05). A dose-dependent, significantly higher intra-cytoplasmic carbohydrate storage was observed in treated animals. Our data show that AS promotes wound healing due to its preliminary impact on mast-cell distribution, which enhanced collagen synthesis and upregulated angiogenesis, and shortened the healing process by enhancing the intra-cytoplasmic carbohydrate ratio.Uniterms: Allium sativum/effects/rats. Allium sativum/wound healing/study. Allium sativum/mast cells. Allium sativum/angiogenesis. Intra-cytoplasmic carbohydrate.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 92%

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Hydroethanolic Allium sativum extract accelerates excision wound healing: evidence for roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio

Farahpour

Hesaraki

Faraji

et al. 2017

Braz. J. Pharm. Sci.

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“…Despite their well-known role in allergy and anaphylaxis, mast cells are emerging as general antennae of the microenvironment regulating physiologic and pathologic immune responses (7,8). In the context of the TME, mast cells are recognized as an early and persistent infiltrating cell type involved in angiogenesis, tissue remodeling, and immune modulation (9).…”

Section: Introductionmentioning

confidence: 99%

Mast Cells Boost Myeloid-Derived Suppressor Cell Activity and Contribute to the Development of Tumor-Favoring Microenvironment

Danelli

Frossi

Gri

et al. 2015

Cancer Immunology Research

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Inflammation plays crucial roles at different stages of tumor development and may lead to the failure of immune surveillance and immunotherapy. Myeloid-derived suppressor cells (MDSC) are one of the major components of the immune-suppressive network that favors tumor growth, and their interaction with mast cells is emerging as critical for the outcome of the tumor-associated immune response. Herein, we showed the occurrence of cellto-cell interactions between MDSCs and mast cells in the mucosa of patients with colon carcinoma and in the colon and spleen of tumor-bearing mice. Furthermore, we demonstrated that the CT-26 colon cancer cells induced the accumulation of CD11b þ Gr1 þ immature MDSCs and the recruitment of protumoral mast cells at the tumor site. Using ex vivo analyses, we showed that mast cells have the ability to increase the suppressive properties of spleenderived monocytic MDSCs, through a mechanism involving IFNg and nitric oxide production. In addition, we demonstrated that the CD40:CD40L cross-talk between the two cell populations is responsible for the instauration of a proinflammatory microenvironment and for the increase in the production of mediators that can further support MDSC mobilization and tumor growth. In light of these results, interfering with the MDSC:mast cell axis could be a promising approach to abrogate MDSC-related immune suppression and to improve the antitumor immune response. Cancer Immunol Res; 3(1); 85-95. Ó2014 AACR.

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“…Several studies in human disease and animal models allocated an essential role of MCs to autoimmunity [21,[23][24][25][26][27]. However, with the development of novel MC-deficient mouse strains, the contribution of MCs to this type of disorders became questionable and is now under reevaluation for individual autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

Conditional depletion of mast cells has no impact on the severity of experimental epidermolysis bullosa acquisita

Kasprick

Scholten³

et al. 2015

Eur J Immunol

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The role of mast cells (MCs) in autoimmunity is the matter of an intensive scientific debate. Based on observations in different MC-deficient mouse strains, MCs are considered as fundamental players in autoimmune diseases. However, most recent data suggest that the outcome of such diseases is strongly affected by the individual mouse strain used. By the use of two c-Kit mutant MC-deficient mouse strains and one c-Kit-independent strain, we here investigated the role of MCs in a systemic Ab transfer model of epidermolysis bullosa acquisita, a subepidermal autoimmune blistering skin disease characterized by autoantibodies against type VII collagen. While C57BL/6J-Kit W-sh/W-sh mice developed an unexpected increased blistering phenotype, no significant differences to WT controls were seen in WBB6F 1 -Kit W/W-v or the novel Mcpt5-Cre iDTR animals. Interestingly, in a local Ab transfer model, which induces a localized disease, we showed that application of high concentrations of anti-COL7 (where COL7 is type VII collagen) Abs induced MC activation and MC-dependent edema formation that did, however, not contribute to blister induction. Our results indicate that in the autoimmune disorder epidermolysis bullosa acquisita MCs do not contribute to the immune-mediated tissue injury. Modern c-Kit mutant-independent MC-deficient mouse strains will help to further redefine the role of MCs in autoimmunity.Keywords: Animal models r autoimmunity r conditional depletion r epidermolysis bullosa acquisita r mast cellsAdditional supporting information may be found in the online version of this article at the publisher's web-site IntroductionAutoimmune bullous dermatoses represent a group of organspecific autoimmune diseases with autoantibodies targeting Correspondence: Prof. Frank Petersen e-mail: fpetersen@fz-borstel.de desmosomal and hemidesmosomal structural proteins of skin and mucous membranes. Within this group, epidermolysis bullosa acquisita (EBA) represents a subepidermal blistering disorder characterized by circulating and tissue-bound autoantibodies (mostly of the IgG subclass) against type VII collagen (COL7), a major component of anchoring fibrils essential for the attachment of epidermis and dermis [1,2]. The pathogenicity of anti-COL7C 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.eji-journal.eu Eur. J. Immunol. 2015. 45: 1462-1470 Innate immunity 1463Abs in EBA has been well documented, both in vitro and in vivo [3]. Studies in men and mice revealed that the deposition of anti-COL7 IgG at the dermal-epidermal junction results in complement activation predominantly via the alternative pathway and subsequent neutrophil infiltration into the dermis of the skin. By releasing ROS and proteases, activated neutrophils are thought to destroy the basement membrane zone and mediate dermal-epidermal separation and blister formation [4,5]. Thus, patients with EBA mainly suffer from fragile skin, blistering, and scarring with milia formation [6]. Although therapeutic approaches include systemic corticosteroids, immunosuppre...

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Mast Cells

Cited by 211 publications

References 195 publications

Hydroethanolic Allium sativum extract accelerates excision wound healing: evidence for roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio

Hydroethanolic Allium sativum extract accelerates excision wound healing: evidence for roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio

Mast Cells Boost Myeloid-Derived Suppressor Cell Activity and Contribute to the Development of Tumor-Favoring Microenvironment

Conditional depletion of mast cells has no impact on the severity of experimental epidermolysis bullosa acquisita

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