Mast Cells in the Central Nervous System of Immunized NC-strain Mice

Ishibashi, Haruo; Sawano, Juzo

doi:10.2535/ofaj1936.59.1_1

Cited by 3 publications

(2 citation statements)

References 40 publications

(7 reference statements)

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“…In those animals were treatment was based on the same method, m.c. in the central nervous system had almost the same appearance (Ishibashi and Sawano, 1982) as in the adrenal glands. There have been many reports on degranulation caused by Co48/80, and degranulation as occurred in A.A.A., several findings have been reported.…”

Section: ) Electron Microscopic Findingsmentioning

confidence: 79%

“…Slices were cut at a thickness of 30p, fixed on slideglasses and exposed to o-phthalaldehyde gas or covered with 1% o-phthalaldehyde in xylene (or paraxylene) (Juhlin and Shelly, 1966;Shelly et al, 1968). They then were removed and put into xylene, while draining away excess ophthalaldehyde and mounted with tetrahydrofurfuryl alcohol (Ishibashi and Sawano, 1982).…”

Section: ) Preparation For Histamine Fluorometrymentioning

confidence: 99%

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The Effects of Cortisone on Mast Cells in the Adrenal Glands

Okinaga

1983

Okajimas Folia Anatomica Japonica

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Summary: NC-strain mice have a constitution, that anaphylactic shock is very likely to occur, so if ovalbumin is administered in terms, almost all the mice die of shock by the third injection. The more sensitizations were performed, using ovalbumine as an antigen, the profunder became the mices allergic condition. The number of mast cells increased especially in the fascicular zone of the adrenal glands and the fluorescence intensity of them became stronger. Under light microscopic studies, the granules in a cell decreased and they were stained bluish purple by toluidine blue and under electron microscopic studies the number of the granules increased with high electron density. Once, either ovalbumin or compound 48/80 was injected under these allergic conditions, the mice showed remarkable symptoms of allergy and many of them died of anaphylactic shock. The fluorescence of histamine in the mast cells decreased and most of the mast cell granules stained pink. Under the electron microscopic studies the density of the granules decreased extremely and most of them were swollen, some of them united with each other and others released themselves from the plasma membrane. Whenever prednisolone was injected the day before the challenge or compound 48/80 the allergy symptoms were not serious. The granules became small and stained dark blue and there occurred only a small amount of degranulation. The density of the granules increased tremendous and there were many granules which had a surrounding space between the cytoplasm and themselves. Through pretreatment with prednisolone, the fluorescence intensity of histamine became slightly weaker than before. But after the challenge or compound 48/80, it scarcely changed. The symptoms of shock, changes of granules and the release of histamine etc. were clearly protected by pretreatment with prednisolone.

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Section: ) Electron Microscopic Findingsmentioning

confidence: 79%

Section: ) Preparation For Histamine Fluorometrymentioning

confidence: 99%

The Effects of Cortisone on Mast Cells in the Adrenal Glands

Okinaga

1983

Okajimas Folia Anatomica Japonica

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Cellular localization and possible functions for brain histamine: Recent progress

Hough

1988

Progress in Neurobiology

237

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Study of the Patch Test Reactions to <i>Myocoptes musculinus</i> (Kekuidani) of NC/F Mice (Atopic Model Mice)

Sugiura

Hayakawa

et al. 2002

Exog Dermatol

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Background: Atopic dermatitis is considered to be developed by the IgE-mediated immediate allergy and by the delayed hypersensitivity to causative allergens. We have previously reported that IgE-mediated type I allergy to mites contributed to the development of skin eruptions on atopic model mice (NC mice). Objective: This time, we studied the delayed hypersensitivity skin reaction to mites in NC/F mice. Methods: We conducted 48-hour closed patch testing with Myocoptes musculinus (kekuidani) that is a parasite in NC/F mice and BALB/C mice. Results: At both the 48- and 72-hour readings, 7 (87.5%) out of 8 NC/F mice tested showed positive reactions to M. musculinus. All BALB/C mice showed negative reactions to M. musculinus. All animals showed negative reactions to white petrolatum. Conclusion: Our previous data and results of this study give positive proof that both IgE-mediated immediate allergy and cell-mediated delayed hypersensitivity to a mite antigen contribute to the development of skin eruptions on NC/F mice resembling human atopic dermatitis.

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Mast Cells in the Central Nervous System of Immunized NC-strain Mice

Cited by 3 publications

References 40 publications

The Effects of Cortisone on Mast Cells in the Adrenal Glands

The Effects of Cortisone on Mast Cells in the Adrenal Glands

Cellular localization and possible functions for brain histamine: Recent progress

Study of the Patch Test Reactions to <i>Myocoptes musculinus</i> (Kekuidani) of NC/F Mice (Atopic Model Mice)

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