Mast Cells in Pterygium Number and Phenotype

Nakagami, T

doi:10.1016/s0021-5155(98)00069-0

Cited by 29 publications

(19 citation statements)

References 16 publications

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“…CD34-positive cells were not restricted to vascular endothelial cells, but also appeared in the subepithelial connective tissue. The expression pattern of c-Kit in primary pterygium was similar to that found by Nakagami, 21 and it was expressed in pterygium epithelial cells and subepithelial stroma cells. The expression of progenitor cell's antigen on pterygium tissue is a sign of involvement of bone marroworiginated cells.…”

Section: Discussionsupporting

confidence: 84%

Involvement of bone marrow-derived stem and progenitor cells in the pathogenesis of pterygium

Song

Kang

et al. 2004

Eye

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Aims To evaluate the involvement of multipotential stem and progenitor cells in the pathogenesis of pterygium. Methods Paraffin-embedded and snap-frozen primary pterygium (n ¼ 10) were serially sectioned and analysed immunohistochemically to determine the expression level of AC133 (marker for the primitive haematopoietic progenitors), CD34 (marker for the haematopoietic progenitor cells and endothelium), c-Kit (marker for haematopoietic and stromal progenitor cells), and STRO-1 (a differentiation antigen present on bone marrow fibroblast cells and on various nonhaematopoietic progenitor cells). Results In all the primary pterygium, immunoreactivity of AC133 and STRO-1 was found in some of the epithelial and stromal cells, CD34 was observed in the vascular endothelium, and some scattered ovoidal cells were found in the subepithelial connective tissue. C-Kit was expressed mainly in the basal epithelium of the head portions, and some spindle-shaped stromal cells. There is no immunoreactivity of AC133, c-Kit, and STRO-1 in normal conjunctiva, whereas CD34 was mildly stained with vessel wall. Conclusion Multipotential stem and progenitor cells may be involved in the pathogenesis of pterygium through its differentiation into fibroblasts and vascular endothelial cells.

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Section: Discussionsupporting

confidence: 84%

Involvement of bone marrow-derived stem and progenitor cells in the pathogenesis of pterygium

Song

Kang

et al. 2004

Eye

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“…5,[8][9][10][11][12][13][14][15][16] The risk factors for recurrence include geographic location 17 , age 15 , morphology and fleshiness or vascularity of pterygium 15 and other factors such as allergy or immunological factors. [18][19][20] This study did not demonstrate any significant association between recurrence and vascularity (atrophic, vascularised), allergy to dust, allergy to perfumes and spray, history of asthma, or type of occupation (indoor or outdoor) and gender.…”

Section: Discussioncontrasting

confidence: 56%

Epidemiology and recurrence rate of pterygium post excision in Ghanaians

Essuman

Ntim-Amponsah²,

Vemuganti

et al. 2014

Ghana Medical Journal

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SUMMARYObjectives: To determine the epidemiology and recurrence rate of pterygium after excision using bare sclera technique Design: Prospective non-comparative study. Setting: Ophthalmology unit, Korle-Bu Teaching Hospital, Accra, Ghana. Methods: The study involved 60 consecutive patients with primary apterygial from July 1998 to December 2000 who had bare sclera excision after informed consent. They were post-operatively followed up for 30-months. Results: Thirty-five patients (58%) were females. The patients' ages ranged from 17-75 years, mean (±12.6). Overall recurrence was 22(37%). The main complications encountered include were granuloma 20 %( n=12), restriction in medial rectus muscle motility 2(3%), persistent vascularisation at excision site 2(3%) and adherence leucoma with uveitis 1(2%). No significant association was found between recurrence and pterygium morphology, calcification, allergy and occupation (indoor or outdoor). Conclusion:The recurrence rate after pterygium excision using bare sclera technique in Ghanaians is high (37%).

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“…With regard to histamine receptors, inhibition of H1 and H2 sub-types, by chemical antagonists, has indicated roles for proliferation and migration (Leonardi et al, 1999). Furthermore, mast cells are more abundant in pterygial tissue compared with normal conjunctiva (Nakagami et al, 1999). Consequently, it is likely that release of histamine from this store will give rise to elevated histamine levels in the local environment of pterygia.…”

Section: Introductionmentioning

confidence: 99%

Pterygial Derived Fibroblasts Express Functionally Active Histamine and Epidermal Growth Factor Receptors

Maini

Collison

Maidment

et al. 2002

Experimental Eye Research

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Mast Cells in Pterygium Number and Phenotype

Abstract: The MC(TC)S appear not to be immune system-related and to have functions in angiogenesis and tissue remodeling. The increase in the number of mast cells caused by nonallergic stimulation may contribute to the pathogenesis of pterygium.

Cited by 29 publications

References 16 publications

Involvement of bone marrow-derived stem and progenitor cells in the pathogenesis of pterygium

Involvement of bone marrow-derived stem and progenitor cells in the pathogenesis of pterygium

Epidemiology and recurrence rate of pterygium post excision in Ghanaians

Pterygial Derived Fibroblasts Express Functionally Active Histamine and Epidermal Growth Factor Receptors

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