Mast cells in lymphomas

Ribatti, Doménico

doi:10.1016/j.critrevonc.2016.03.016

Cited by 18 publications

(14 citation statements)

References 32 publications

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“…Inflammatory cells contribute to the proliferative and invasive capacity of solid and hematological malignancies [ 19 – 21 ]. PDAC is characterized by an abundant inflammatory infiltration consisting in cancer-associated fibroblasts, macrophages, mast cells (MCs) and lymphocytes [ 12 , 22 ].…”

Section: Inflammation In Pdacmentioning

confidence: 99%

Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue

Longo¹,

Brunetti

Gnoni

et al. 2016

Oncotarget

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Pancreatic ductal adenocarcinoma (PDAC) occurs in the majority of cases with early loco-regional spread and distant metastases at diagnosis, leading to dismal prognosis with a 5-year overall survival rate moderately over than 5%. This malignancy is largely resistant to chemotherapy and radiation, but the reasons of the refractoriness to the therapies is still unknown. Evidence is accumulating to indicate that the PDAC microenvironment and vascularity strongly contribute to the clinical features of this disease. In particular, PDAC is characterized by excessive dense extracellular matrix deposition associated to vasculature collapse and hypoxia with low drug delivery, explaining at least partly the low efficacy of antiangiogenic drugs in this cancer. Strategies aimed to modulate tumor stroma favoring vasculature perfusion and chemotherapeutics delivery are under investigation.

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Section: Inflammation In Pdacmentioning

confidence: 99%

Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue

Longo¹,

Brunetti

Gnoni

et al. 2016

Oncotarget

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“…Kaplan–Meier analysis of 22 immune cells showed that activated mast cells were linked to poor prognosis of LSCC, while follicular helper T cells were associated with a better outcome of LSCC. Mast cells, as an important component of tumor microenvironment, have been proved to exist in a large number of solid tumors (Oldford & Marshall, 2015; Ribatti, 2016). Mast cells play both positive and negative roles in tumors, depending on bioactive substances secreted (Ribatti, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Mast cells, as an important component of tumor microenvironment, have been proved to exist in a large number of solid tumors (Oldford & Marshall, 2015; Ribatti, 2016). Mast cells play both positive and negative roles in tumors, depending on bioactive substances secreted (Ribatti, 2016). A large number of studies have shown that high infiltration mast cells in tumors are associated with a good prognosis of patients (Carlini et al, 2010; Dabiri et al, 2004; Welsh et al, 2005), which runs counter to our results.…”

Section: Discussionmentioning

confidence: 99%

Investigating the significance of tumor-infiltrating immune cells for the prognosis of lung squamous cell carcinoma

Yunfen

Zhang

2019

PeerJ

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ObjectiveIncreasing evidence has indicated an association between immune cells infiltration in LSCC and clinical outcome. The aim of this research was tantamount to comprehensively investigate the effect of 22 tumor infiltrating immune cells (TIICs) on the prognosis of LSCC patients.MethodsIn our research, the CIBERSORT algorithm was utilized to calculate the proportion of 22 TIICs in 502 cases from the TCGA cohort. Cases with a CIBERSORT P-value of <0.05 were kept for further study. Using the CIBERSORT algorithm, we first investigated the difference of immune infiltration between normal tissue and LSCC in 22 subpopulations of immune cells. Kaplan-Meier analysis was used to analyze the effect of 22 TIICs on the prognosis of LSCC. An immune risk score model was constructed based on TIICs correlated with LSCC-related recurrence. Multivariate cox regression analysis was used to investigate whether the immune risk score was an independent factor for prognosis prediction of LSCC. Nomogram was under construction to comprehensively predict the survival rate of LSCC.ResultsThe results of the different analysis showed that except of memory B cells, naive CD4+T cells, T cells and activated NK cells, the remaining immune cells all had differential infiltration in normal tissues and LSCC (p < 0.05). Kaplan-Meier analysis revealed two immune cells statistically related to LSCC-related recurrence, including activated mast cells and follicular helper T cells. Immune risk score model was constructed based on three immune cells including resting memory CD4+T cells, activated mast cells and follicular helper T cells retained by forward stepwise regression analysis. The Kaplan-Meier curve indicated that patients in the high-risk group linked to poor outcome (P = 8.277e−03). ROC curve indicated that the immune risk score model was reliable in predicting recurrence risk (AUC = 0.614). Multivariate cox regression analysis showed that the immune risk score model was just an independent factor for prognosis prediction of LSCC (HR = 2.99, 95% CI [1.65–5.40]; P = 0.0002). The nomogram model combined immune risk score and clinicopathologic parameter score to predict 3-year survival in patients with LSCC.ConclusionsCollectively, tumor-infiltrating immune cells play a major role in the prognosis of LSCC.

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“…Tryptase has its molecular targets on the cells or components of the extracellular matrix, causing any proor anti-in ammatory effects 38,42,[58][59][60][61][62] . Most often, tryptase initiates the development of in ammation, causing an increase in the permeability of the capillary wall, increasing the migration of neutrophils, eosinophils, basophils and monocytes beyond the microvasculature 63 including laminin, bronectin, several proteoglycans, etc.…”

Section: Tryptasementioning

confidence: 99%

Protease profile of normal and neoplastic mast cells in the human bone marrow

Atiakshin¹,

Buchwalow²,

Horny³

et al. 2020

Preprint

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Abstract Mast cells (MC) are immune cells that produce a variety of mediators, such as proteases, that are important in the body’s immune responses. MC proteases have pronounced multifunctionality and in many respects determine the biological characteristics of the organ-specific MC population. Although, increased numbers of MC are one of the objective mastocytosis signs, a detailed assessment of the proteases biogenesis and excretion mechanisms in the bone marrow has not yet been carried out. Here, we performed an analysis of the expression of proteases in patients with various forms of mastocytosis. We presented data on intracellular protease co-localization in the bone marrow MCs and discussed their implication in secretory pathways of MCs in the development of the disease. Characterization of MC proteases expression during mastocytosis can be used to refine the MC classification, make a prognosis, and increase the effectiveness of targeted therapy.

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Mast cells in lymphomas

Cited by 18 publications

References 32 publications

Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue

Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue

Investigating the significance of tumor-infiltrating immune cells for the prognosis of lung squamous cell carcinoma

Protease profile of normal and neoplastic mast cells in the human bone marrow

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