Mast Cells in Human Adipose Tissue: Link with Morbid Obesity, Inflammatory Status, and Diabetes

Divoux, Adeline; Moutel, Sandrine; Poitou, Christine; Lacasa, Danièle; Veyrie, Nicolas; Aissat, Abdelhalim; Arock, Michel; Guerre-Millo, Michéle; Clément, Karine

doi:10.1210/jc.2012-1532

Cited by 143 publications

(114 citation statements)

References 27 publications

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“…It has been reported that the serum levels of mast cell-derived tryptase and the number of adipose tissue mast cells are increased in obese patients and high fat diet-fed mice, respectively (42,43). Mast cells in adipose tissue have been proposed to contribute to the pathophysiology of obesity and diabetes and related systemic inflammation (44). MS and some components in particular (e.g.…”

Section: Discussionmentioning

confidence: 99%

The link between chronic spontaneous urticaria and metabolic syndrome

Veña¹,

Cassano²

2017

Eur Ann Allergy Clin Immunol

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Summary Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease and is considered a chronic low-level systemic inflammatory condition. Recent preliminary findings have shown an increased prevalence of MS among patients with chronic urticaria (CU) as compared to controls, with a particularly higher prevalence detected in patients with uncontrolled CU. Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with MS, including a pro-inflammatory state, increased oxidative stress, alterations in adipokine profile

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Section: Discussionmentioning

confidence: 99%

The link between chronic spontaneous urticaria and metabolic syndrome

Veña¹,

Cassano²

2017

Eur Ann Allergy Clin Immunol

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“…The increase in mast cells in visceral fat of obese mice [15] and in human subcutaneous abdominal fat [2], suggests their role in the pathogenesis of obesity and insulin resistance and infl ammatory status [2,15]. Similarly ,in an adult prospective study examining the effect of fat distribution on asthma found that abdominal obesity was a risk factor for incident asthma in males and females.…”

Section: Discussionmentioning

confidence: 99%

“…Mast cells are found to be more abundant in subcutaneous abdominal adipose tissue from obese humans than from non-obese humans [2]. Total serum tryptase (ST) could be considered as a measure of mast cell activity [3].…”

Section: Introductionmentioning

confidence: 99%

Is Serum Tryptase a Valuable Marker for Obesity-Bronchial Asthma Interrelationship in Children?

Ta¹,

Kamel²,

Al-Aziz³

et al. 2017

Open J Trauma

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Background: Asthma among obese represents a unique phenotype. Mast cells are more abundant in obese. Serum tryptase (ST) is a marker of mast cell numbers or activity. Since obesity and asthma have been linked in epidemiological studies, a possible higher mast cell activity in obesity could be a factor between the two conditions. This study was to investigate ST and its potential association between obesity and childhood asthma.Methods: Study recruited 60 asthmatic children, their age ranged from 5-16 years. They were divided according to BMI centile to 30 obese and 30 non-obese asthmatics. Thirty healthy non-asthmatic, nonatopic and non-obese children; were included as a healthy control. Serum tryptase, atopy (skin prick test reactivity) and spirometry were assessed.Results: Frequency of atopy and positive skin prick test signifi cantly increased among obese more than non-obese asthmatics (P<0.05, OR = 1.96, 95% CI = 1.27-3.24). FEV1% of predicted mean levels were lower among obese than non-obese asthmatics (p<0.05). ST was signifi cantly higher in asthmatics than in controls with a mean ±SD of 53.3±13.78 ng/ml and 10.06±4.39 ng/ml respectively. ST was higher in obese than non-obese asthmatics with a mean ±SD of 71.73±19.17 ng/ml and 34.5±8.68 ng/ml respectively (P<0.05). There was a negative correlation between ST and FEV1 % of predicted and positive correlations between ST and age, BMI, and waist circumference among asthmatics. Conclusion:Mast cells play a role in both obesity and asthma, serum tryptase, being a marker of mast cell activation, could represent a link between them.

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“…Of special importance in fibrosis are mast cells that, besides having an immune function, have recently been identified to play an important role in disease processes. Divoux et al, (2012) reported that mast cells were activated in human adipose tissue and were localised at regions where fibrosis occurs. Mast cells are also implicated in the development of lung fibrosis in that 5-HT is taken up from the serum via the 5-HT transporter (SERT) and carried to the site of injury where it is released.…”

Section: Discussionmentioning

confidence: 99%

Sibutramine, a serotonin–norepinephrine reuptake inhibitor, causes fibrosis in rats

Oberholzer

Schoor

Bester

2015

Environmental Toxicology and Pharmacology

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Sibutramine hydrochloride monohydrate is a weight loss agent indicated for the treatment of obesity. Although it has been banned from most markets, studies are still relevant as it is often a hidden ingredient in herbal and over the counter slimming products. Sibutramine induces liver fibrosis with steatosis in female Sprague-Dawley rats fed a high-energy diet without significant weight gain. In this study, using the same animal model, the effect of Sibutramine on lung morphology was investigated using histological evaluation of the terminal bronchiole and transmission electron microscopy evaluation of the respiratory tissue. From these results Sibutramine was found to induce lung fibrosis in Sprague-Dawley rats as increased collagen synthesis, mast cell accumulation and aggregates of Bronchus Associated Lymphoid Tissue (BALT) in the terminal bronchiole as well as increased collagen deposition in the respiratory tissue was seen.

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Mast Cells in Human Adipose Tissue: Link with Morbid Obesity, Inflammatory Status, and Diabetes

Cited by 143 publications

References 27 publications

The link between chronic spontaneous urticaria and metabolic syndrome

The link between chronic spontaneous urticaria and metabolic syndrome

Is Serum Tryptase a Valuable Marker for Obesity-Bronchial Asthma Interrelationship in Children?

Sibutramine, a serotonin–norepinephrine reuptake inhibitor, causes fibrosis in rats

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