Mast cells in cutaneous tumors: innocent bystander or maestro conductor?

Biswas, Asok; Richards, Joanna E.; Massaro, Joseph M.; Mahalingam, Meera

doi:10.1111/j.1365-4632.2012.05745.x

Cited by 25 publications

(40 citation statements)

References 26 publications

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“…In line with the present results, Biswas et al [13] have reported lower mast cell counts in melanoma compared with nevi. Even though mast cells have usually been Overall survival according to tryptase + mast cell counts (median count = 17, n = 33).…”

Section: Discussionsupporting

confidence: 95%

“…In fact, these findings are in line with some previous reports [13,29]. Our findings shed new light on the possible role of mast cells and their major proteinases in malignant melanoma.…”

Section: Discussionsupporting

confidence: 93%

“…Cutaneous squamous cell and basal cell carcinomas did not show statistically significant differences in mast cells counts and, although histogenetically different from melanocytic lesions, the absolute mast cell counts were close to those observed in intradermal nevi [13]. In Merkel cell carcinoma, an increased number of mast cells was associated with poor patient prognosis [14].…”

Section: Introductionmentioning

confidence: 87%

“…In melanoma, the density of mast cells has been shown to be elevated [16] and to correlate with increased microvessel density [17,18]. However, decreased counts of mast cells in melanomas compared with benign nevi have also been reported [13].…”

Section: Introductionmentioning

confidence: 97%

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Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

Siiskonen

Poukka

Bykachev³

et al. 2015

Melanoma Research

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The role of mast cells in cutaneous melanoma remains unclear. Tryptase and chymase are serine proteinases and major proteins in mast cell secretory granules. Therefore, this study aimed to investigate the presence of tryptase and chymase mast cells in benign and malignant cutaneous melanocytic lesions and in lymph node metastases of melanomas. The presence of positively stained mast cells was correlated with clinicopathological characteristics in invasive melanomas. Paraffin-embedded sections of 28 benign (13 intradermal, 10 compound, and five junctional nevi) and 26 dysplastic nevi, 15 in-situ melanomas, 36 superficially (pT1, Breslow's thickness<1 mm), and 49 deeply (pT4, Breslow's thickness>4 mm) invasive melanomas and 30 lymph node metastases were immunohistochemically stained for mast cell tryptase and chymase, and immunopositive cells were counted using the hotspot counting method. The mean count of tryptase and chymase mast cells was lower in invasive melanomas compared with in-situ melanomas and dysplastic and benign nevi. In deeply invasive melanomas, the difference was statistically significant compared with dysplastic nevi (P=0.003 for tryptase and P=0.009 for chymase) and in-situ melanomas (0.043 for tryptase). Low numbers of tryptase mast cells were associated with poor overall survival (P=0.031) in deeply invasive melanomas and with a more advanced stage (T1b, P=0.008) in superficially invasive melanomas. Low numbers of chymase mast cells were associated with microsatellites (P=0.017) in deeply invasive melanomas. The results suggest that these serine proteinases of mast cells may be protective in the pathogenesis of melanoma.

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Section: Discussionsupporting

confidence: 95%

“…In fact, these findings are in line with some previous reports [13,29]. Our findings shed new light on the possible role of mast cells and their major proteinases in malignant melanoma.…”

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

Siiskonen

Poukka

Bykachev³

et al. 2015

Melanoma Research

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“…Studies have allowed substantial progress in understanding the role of MCs in tumorigenesis and progression but further studies are necessary to completely elucidate their impact on the pathophysiology of cancer [30,31,32,33,34,35,36,37]. …”

Section: Mast Cells In Cancermentioning

confidence: 99%

Mast Cell-Targeted Strategies in Cancer Therapy

Ammendola

Sacco

Sammarco

et al. 2016

Transfus Med Hemother

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Mast cells (MCs) are cells that originate in the bone marrow from pluripotent CD34+ hematopoietic stem cells. Precursors of MCs migrate through the circulation to their target tissues, completing their maturation process into granulated cells under the influence of several microenvironment growth factors. The most important of these factors is the ligand for the c-Kit receptor (c-Kit-R) namely stem cell factor (SCF), secreted mainly by fibroblasts and endothelial cells (ECs). SCF also regulates development, survival and de novo proliferation of MCs. It has already been demonstrated that gain-of-function mutations of gene c-Kit encoding c-Kit-R result in the development of some tumors. Furthermore, MCs are able also to modulate both innate and adaptive immune response and to express the high-affinity IgE receptor following IgE activation. Among the other IgE-independent MC activation mechanisms, a wide variety of other surface receptors for cytokines, chemokines, immunoglobulins, and complement are also described. Interestingly, MCs can stimulate angiogenesis by releasing of several pro-angiogenic cytokines stored in their cytoplasm. Studies published in the last year suggest that angiogenesis stimulated by MCs may play an important role in tumor growth and progression. Here, we aim to focus several biological features of MCs and to summarize new anti-cancer MC-targeted strategies with potential translation in human clinical trials.

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Skin and Adnexal Structures

Mahalingam¹,

Reddy²

2022

Gattuso's Differential Diagnosis in Surgical Pathology

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Mast cells in cutaneous tumors: innocent bystander or maestro conductor?

Cited by 25 publications

References 26 publications

Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

Mast Cell-Targeted Strategies in Cancer Therapy

Skin and Adnexal Structures

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