Mast Cells in Cardiac Remodeling: Focus on the Right Ventricle
Argen Mamazhakypov,
Abdirashit Maripov,
Akpay S. Sarybaev
et al.
Abstract:In response to various stressors, cardiac chambers undergo structural remodeling. Long-term exposure of the right ventricle (RV) to pressure or volume overload leads to its maladaptive remodeling, associated with RV failure and increased mortality. While left ventricular adverse remodeling is well understood and therapeutic options are available or emerging, RV remodeling remains underexplored, and no specific therapies are currently available. Accumulating evidence implicates the role of mast cells in RV remo… Show more
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