Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment

Abstract

Knowledge of the biological effects of molecular hydrogen (H2), hydrogen gas, is constantly advancing, giving a reason for the optimism in several healthcare practitioners regarding the management of multiple diseases, including socially significant ones (malignant neoplasms, diabetes mellitus, viral hepatitis, mental and behavioral disorders). However, mechanisms underlying the biological effects of H2 are still being actively debated. In this review, we focus on mast cells as a potential target for H2 at the specific tissue microenvironment level. H2 regulates the processing of pro-inflammatory components of the mast cell secretome and their entry into the extracellular matrix; this can significantly affect the capacity of the integrated-buffer metabolism and the structure of the immune landscape of the local tissue microenvironment. The analysis performed highlights several potential mechanisms for developing the biological effects of H2 and offers great opportunities for translating the obtained findings into clinical practice.

Hydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats

“…Through secretome components, MCs are intimately involved in the genesis of adaptive and pathological conditions and represent not only an informative marker of disease progression but also a promising therapeutic target. Specific MC proteases, such as tryptases, are of great importance [31].…”

Cyto- and Histopographic Assessment of CPA3-Positive Testicular Mast Cells in Obstructive and Non-Obstructive Azoospermia

“…On the one hand, MCs have a diverse repertoire of receptors that provide signaling pathways for selective responses to external and internal stimuli. On the other hand, MCs can highly selectively secrete diverse mediators, such as cytokines and chemokines, to achieve the required effects on the immune and stromal landscapes of specific tissue microenvironments [13][14][15][16][17][18][19][20][21][22]. Specific mast cell proteases, such as tryptase, chymase, and carboxypeptidase A3, are of particular significance in the formation of the proinflammatory and profibrotic background of local tissue niches [23][24][25][26][27][28][29][30].…”