Mast cells are activated by <i>Leishmania mexicana</i> LPG and regulate the disease outcome depending on the genetic background of the host

Villaseñor-Cardoso, M. I.; Salaiza, Norma; Delgado, João; Gutiérrez‐Kobeh, Laila; Pérez‐Torres, Armando; Becker, Ingeborg

doi:10.1111/j.1365-3024.2008.01042.x

Cited by 24 publications

(22 citation statements)

References 36 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The facilitating role of neutrophils has been associated with their capacity to phagocytose the parasites and rapidly transport them from the infection site, thus avoiding the toxic effects of complement and the local immune responses [7]. The inflammatory response aids Leishmania -infected phagocytic cells to enter lymphatic vessels, favoring parasite distribution towards peripheral tissues [32]. It is therefore tempting to speculate that augmented IL-1β production possibly facilitates disease progression in patients with DCL by enhancing the inflammatory response and thereby aiding parasite dissemination.…”

Section: Discussionmentioning

confidence: 99%

Disease Severity in Patients Infected with Leishmania mexicana Relates to IL-1β

et al. 2012

View full text Add to dashboard Cite

Leishmania mexicana can cause both localized (LCL) and diffuse (DCL) cutaneous leishmaniasis, yet little is known about factors regulating disease severity in these patients. We analyzed if the disease was associated with single nucleotide polymorphisms (SNPs) in IL-1β (−511), CXCL8 (−251) and/or the inhibitor IL-1RA (+2018) in 58 Mexican mestizo patients with LCL, 6 with DCL and 123 control cases. Additionally, we analyzed the in vitro production of IL-1β by monocytes, the expression of this cytokine in sera of these patients, as well as the tissue distribution of IL-1β and the number of parasites in lesions of LCL and DCL patients. Our results show a significant difference in the distribution of IL-1β (−511 C/T) genotypes between patients and controls (heterozygous OR), with respect to the reference group CC, which was estimated with a value of 3.23, 95% CI = (1.2, 8.7) and p-value = 0.0167), indicating that IL-1β (−511 C/T) represents a variable influencing the risk to develop the disease in patients infected with Leishmania mexicana. Additionally, an increased in vitro production of IL-1β by monocytes and an increased serum expression of the cytokine correlated with the severity of the disease, since it was significantly higher in DCL patients heavily infected with Leishmania mexicana. The distribution of IL-1β in lesions also varied according to the number of parasites harbored in the tissues: in heavily infected LCL patients and in all DCL patients, the cytokine was scattered diffusely throughout the lesion. In contrast, in LCL patients with lower numbers of parasites in the lesions, IL-1β was confined to the cells. These data suggest that IL-1β possibly is a key player determining the severity of the disease in DCL patients. The analysis of polymorphisms in CXCL8 and IL-1RA showed no differences between patients with different disease severities or between patients and controls.

show abstract

Section: Discussionmentioning

confidence: 99%

Disease Severity in Patients Infected with Leishmania mexicana Relates to IL-1β

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Similarly, studies of L. mexicana infections further support the hypothesis that the host background frames the immune response of mast cells [95]. First, mast cells from C57BL/6 mice express higher levels of TLR2, TNF-α and IL-10 than those from BALB/c in basal conditions as well as upon stimulation with L. mexicana LPG.…”

Section: Mast Cellsmentioning

confidence: 73%

“…Mast cell infiltration peaks at around the third day in susceptible BALB/c mice, but in genetically resistant C57BL/6 mice, mast cell infiltration peaks after 1 week and remains high for at least 8 weeks. These results have led the authors to hypothesize that a high influx of mast cells in the initial stages of infection facilitates disease progression [95]. These observed differences in the kinetics of mast cell infiltration and mast cell gene expression lead us to hypothesize that there is a direct relationship between mast cell phenotype and host susceptibility.…”

Section: Mast Cellsmentioning

confidence: 99%

“…Indeed, data from L. mexicana , L. donovani and L. major infection show that there are host-specific differences in mast cell recruitment, degranulation and cytokine secretion. It is hypothesized that these differences facilitate parasite survival in susceptible mice but promote parasite clearance from their resistant counterparts [22, 95]. In contrast, a study of L. amazonensis infection showed that both resistant and susceptible mice had similar levels of mast cell infiltration during the initial stages of infection [50].…”

Section: Histaminementioning

confidence: 99%

See 1 more Smart Citation

Eosinophils and mast cells in leishmaniasis

Rodríguez

Wilson

2014

Immunol Res

View full text Add to dashboard Cite

Leishmania spp. are parasitic protozoa endemic in tropical and subtropical regions and the causative agent of leishmaniasis, a collection of syndromes whose clinical manifestations vary according to host and pathogen factors. Leishmania spp. are inoculated into the mammalian host by the bite of an infected sand fly, whereupon they are taken up by phagocytosis, convert into the replicative amastigote stage within macrophages, reproduce, spread to new macrophages and cause disease manifestations. A curative response against leishmaniasis depends in the classical activation of macrophages and the IL-12-dependent onset of an adaptive type 1 response characterized by the production of IFN-γ. Emerging evidence suggests that neutrophils, dendritic cells and other immune cells can serve as either temporary or stable hosts for Leishmania spp. Furthermore, it is becoming apparent that the initial interactions of the parasite with resident or early recruited immune cells can shape both the macrophage response and the type of adaptive immune response being induced. In this review, we compile a growing number of studies demonstrating how the earliest interactions of Leishmania spp. with eosinophils and mast cells influence the macrophage response to infection and the development of the adaptive immune response, hence, determining the ultimate outcome of infection.

show abstract

“…Moreover, an in vivo study showed that after infection with L. mexicana , the number of MCs increased more rapidly and to a greater level, with significantly higher levels of parasites in the lesions of BALB/c mice compared to C57BL/6 mice. This indicates that MCs regulate the outcome of leishmaniasis and is dependent on the genetic background of the host (68). Conversely, a recent study showed that MC has no impact on the severity of cutaneous leishmaniasis in mice infected with L. major .…”

Section: Mcs In Leishmania Spp Infectionmentioning

confidence: 99%

The Roles of Mast Cells in Parasitic Protozoan Infections

Huang

2017

Front. Immunol.

View full text Add to dashboard Cite

Protozoan parasites such as Plasmodium spp., Leishmania spp., Trypanosoma spp., and Toxoplasma gondii are major causes of parasitic diseases in both humans and animals. The immune system plays a critical role against protozoa, but their immune mechanism remains poorly understood. This highlights the need to investigate the function of immune cells involved in the process of parasite infections and the responses of host immune system to parasite infections. Mast cells (MCs) are known to be central players in allergy and anaphylaxis, and it has been demonstrated that MCs have crucial roles in host defense against a number of different pathogens, including parasites. To date, there are many studies that have examined the interaction of helminth-derived antigens and MCs. As one of the major effector cells, MCs also play an important role in the immune response against some parasitic protozoa, but their role in protozoan infections is, however, less well characterized. Herein, we review the current knowledge about the roles of MCs and their mediators during infections involving highly pathogenic protozoa including Plasmodium spp., Leishmania spp., Trypanosoma spp., and T. gondii. We offer a general review of the data from patients and experimental animal models infected with the aforementioned protozoa, which correlate MCs and MC-derived mediators with exacerbated inflammation and disease progression as well as protection against the parasitic infections in different circumstances. This review updates our current understanding of the roles of MCs during parasitic protozoan infections, and the participation of MCs in parasitic protozoan infections could be of a potential therapeutic target.

show abstract

Mast cells are activated by Leishmania mexicana LPG and regulate the disease outcome depending on the genetic background of the host

Cited by 24 publications

References 36 publications

Disease Severity in Patients Infected with Leishmania mexicana Relates to IL-1β

Disease Severity in Patients Infected with Leishmania mexicana Relates to IL-1β

Eosinophils and mast cells in leishmaniasis

The Roles of Mast Cells in Parasitic Protozoan Infections

Contact Info

Product

Resources

About