Mast Cells Appearing in Long‐term Skeletal Muscle Cell Cultures of Rat

Cheng, Chang-Xie; Li, Yongnan; Ohno, Hiroshi; Sawanobori, Kazuko; Li, Yanchao; Shimada, Osamu; Atsumi, Saoko

doi:10.1002/ar.20595

Cited by 6 publications

(4 citation statements)

References 35 publications

(38 reference statements)

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“…The results of the present study, which revealed high levels of H 1 R expression during early myogenesis, along with the aforementioned previous observations, suggested that high histamine levels may stimulate myoblast proliferation during the early phases of differentiation. This hypothesis is further supported by the observations of a previous study, which demonstrated that mast cell precursors migrated from bone marrow to skeletal muscle tissue in 17 to 20-day-old rat fetuses, indicating interactions between the professional histamine-producing mast cells and skeletal muscle cells in proliferation or differentiation ( 14 ).…”

Section: Discussionsupporting

confidence: 79%

Identification of histamine receptor subtypes in skeletal myogenesis

Chen

Stegaev

Kouri

et al. 2014

Molecular Medicine Reports

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To date, conventional and/or novel histamine receptors (HRs) have not been investigated in mouse skeletal myogenesis. Therefore, the present study aimed to investigate the HR-subtypes in skeletal myogenesis. The myogenesis of C2C12 skeletal myoblasts was evaluated using desmin, myogenin and myosin heavy chain (Myh) as early, intermediate and late differentiation markers, respectively. Reverse transcription-quantitative polymerase chain reaction and immunostaining were performed and the messenger RNA (mRNA) expression levels of the HR-subtypes and markers were determined. H1R mRNA was found to be highly expressed in myoblasts at day 0; however, the expression levels were reduced as differentiation progressed. By contrast, H2R mRNA expression remained constant, while H3R mRNA expression increased by 28-, 103- and 198-fold at days 2, 4 and 6 compared with the baseline level (day 0), respectively. In addition, Myh expression increased by 7,718-, 94,487- and 286,288-fold on days 2, 4 and 6 compared with the baseline expression level (day 0). Weak positive staining of the cells for H3R protein was observed on day 2, whereas highly positive staining was observed on days 4 and 6. HR expression during myogenesis was, in part, regulated by the stage of differentiation. These results along with previous findings indicated possible involvement of H1R in the regulation of progenitor cell mitogenesis and of H2R in the relaxation of acetylcholine-stimulated contraction of muscle cells, following the activation of professional histamine-producing cells, including mast cells. By contrast, H3R may participate in the regulation of specialized myocyte functions, potentially by maintaining the relaxed state under the influence of constitutive H3R activity and low histamine concentrations, locally produced/released by non-professional histamine-producing cells.

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Section: Discussionsupporting

confidence: 79%

Identification of histamine receptor subtypes in skeletal myogenesis

Chen

Stegaev

Kouri

et al. 2014

Molecular Medicine Reports

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“…Absorbedfood allergenic peptides are tolerated in the gut by gut-specific mast cells thereby not inducing noticeable symptoms when the individual is at rest. With exercise, the recently ingested allergen is then directed away from the usual sites of absorption in the gut to skin/and or skeletal muscle compartments containing regions of phenotypically different mast cells [34] and hence, increasing the potential for exercise-induced anaphylaxis. Interestingly, a case of FDEIA has been reported in which food was ingested shortly after exercise; recovery of blood flow following exercise to pre-exercise distribution can take at least 40 min [22].…”

Section: Redistribution Of Blood During Exercise and Mast Cell Heteromentioning

confidence: 99%

Pathophysiology, diagnosis and management of exercise-induced anaphylaxis

Robson-Ansley

Toit

2010

Current Opinion in Allergy &Amp; Clinical Immunology

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Implications for future research are the physiological changes that occur during exercise need deeper consideration to ensure that proposed mechanisms are realistic and actually occur within the time frame and exercise-intensity domain during which the reported FDEIA occurred. These theories must be tested rigorously with sufficiently powered studies if progress is to be made in determining the perplexing pathophysiology of FDEIA.

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“…They posited that at rest, the absorbed food allergenic peptides are tolerated gut‐specific mast cells. However, when physical activity is undertaken, the sudden redistribution of blood transports the allergen away from the gut to the skin and/or skeletal muscle, where phenotypically different mast cells reside . The interaction of the allergen with these different mast cells results in an altered mediator release and the potential for exercise‐induced anaphylaxis.…”

Section: Published Proposed Pathophysiological Mechanisms For Eianmentioning

confidence: 99%

Pathophysiological mechanisms of exercise‐induced anaphylaxis: an EAACI position statement

Ansley

Bonini

Delgado

et al. 2015

Allergy

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This document is the result of a consensus on the mechanisms of exercise-induced anaphylaxis (EIAn), an unpredictable and potentially fatal syndrome. A multidisciplinary panel of experts including exercise physiologists, allergists, lung physicians, paediatricians and a biostatistician reached the given consensus. Exerciseinduced anaphylaxis (EIAn) describes a rare and potentially fatal syndrome in which anaphylaxis occurs in conjunction with exercise. The pathophysiological mechanisms underlying EIAn have not yet been elucidated although a number of hypotheses have been proposed. This review evaluates the validity of each of the popular theories in relation to exercise physiology and immunology. On the basis of this evidence, it is concluded that proposed mechanisms lack validity, and it is recommended that a global research network is developed with a common approach to the diagnosis and treatment of EIAn in order to gain sufficient power for scientific evaluation.Exercise-induced anaphylaxis (EIAn) is a rare, unpredictable, potentially fatal syndrome in which anaphylaxis occurs in conjunction with exercise or physical activity. EIAn may occur independently of food allergen ingestion or may require the ingestion of a food allergen either pre-or postexercise, known as food-dependent exercise-induced anaphylaxis (FDEIAn). The symptoms of FDEIAn may vary in severity; reassuringly, fatalities are rare. EIAn occurs in all ages, in both sexes, and is more common in atopic individuals (1, 2). EIAn is generally reported following submaximal exercise of a relatively short duration; this fact alone eliminates the majority of the proposed pathophysiological mechanisms. EIAn has been described in high-performance athletes and in individuals undertaking only occasional exercise or physical activity; indeed, even nonstrenuous physical activity, for example raking garden leaves, has been reported as a trigger for EIAn.There are now more than one hundred reviews on the topic of EIAn (food dependent and nonfood dependent) upon which much of our current knowledge of the condition is based. A recent publication has reviewed some of the current working hypotheses for (FD)EIAn and indicated that many of these are inappropriate for the physiological changes that occur within the exercise time frame and intensity domain in which EIAn episodes have been reported (3).The aim of the Task Force was threefold: firstly, to evaluate the scientific validity of the current working hypotheses in the context of exercise physiology and immunology; secondly, to provide a position statement on pathophysiological mechanisms underlying EIAn; and finally, to identify research needs. Literature search strategyAn overview of the search method is provided in Fig. 1. Briefly, the primary method to locate potentially eligible studies was a computerized literature search in the 1212Allergy MEDLINE and SportDiscus databases, without any initial restriction on language of publication. A list of search words and terms was compiled using the Boolean ...

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Mast Cells Appearing in Long‐term Skeletal Muscle Cell Cultures of Rat

Cited by 6 publications

References 35 publications

Identification of histamine receptor subtypes in skeletal myogenesis

Identification of histamine receptor subtypes in skeletal myogenesis

Pathophysiology, diagnosis and management of exercise-induced anaphylaxis

Pathophysiological mechanisms of exercise‐induced anaphylaxis: an EAACI position statement

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