Mast cells and tumor angiogenesis

Abstract

Tumor angiogenesis factor (TAF) elicits a strong vasoproliferative response when implanted upon the chorioallantoic membrane (CAM) of the chick embryo. This response is first observed stereomicroscopically 2-3 days after implantation. A 40-fold increase in mast cell density is observed within the vicinity of this implant by 24 h. Mast cells that have been isolated from retired breeder Sprague-Dawley rats fail to evoke a vascular reaction when implanted on the CAM. An intermediate role for the mast cell in tumor angiogenesis is suggested.

Calcifying Fibrous Pseudotumor versus Inflammatory Myofibroblastic Tumor: A Histological and Immunohistochemical Comparison

“…However, there is increasing evidence that mast cells are noted in diseases with neovascularization such as wound repair, hemangioma, and vascular malformations, including some tumors (27,28). It seems likely that mast cells, by secreting cytokines or growth factors, contribute to the proliferation of fibroblasts and vessels in these lesions (29). In support of this theory, our findings of increased mast cells in CFPs appear to correlate well with increased microvascular density.…”

Mast cells and cutaneous malignancies

“…[9][10][11][12][13][14] The increased density of mast cells around many types of tumors is independent of the presence of an inflammatory infiltrate. 26 Cohen et al 27 find that the degree of peribasal cell carcinoma inflammation does not correlate with the relative density of mast cells. This suggests that mast cells are preferentially recruited to the vicinity of basal cell carcinoma (Figure 2).…”

“…65 Mast cell accumulation around the margin of tumors has been observed to peak just as the tumors acquire the angiogenic phenotype, preceding growth of new capillaries towards the tumors. 26,66 Peritumoral mast cell count correlates strongly with microvascular density, melanoma progression and prognosis. 11,12 The angiogenic response to implanted melanoma in mast cell-deficient W/W v mice is delayed and less intense initially.…”

Synthesis and pharmacological evaluation of the individual stereoisomers of 3-[methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent

“…3 Mast cells, given their broad distribution, may therefore play a potentially critical role in a variety of disease states, including multiple sclerosis, rheumatoid arthritis, tumour angiogenesis, cystic fibrosis and irritable bowel syndrome. [4][5][6][7][8] The role of mast cells in angiogenesis and autoimmune conditions opens many possibilities for the development of mast cell directed therapies to treat these conditions. Previous work by Barlow and Walsh 9 described the synthesis and mast cell stabilising properties of a series of novel tetrahydronaphthalene based compounds.…”