Mast cells and postnatal topographic anomalies in mammalian subfornical body and supraoptic crest

Cammermeyer, Jan

doi:10.1007/bf00525056

Cited by 16 publications

(5 citation statements)

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“…Analogously, in spinal cord the HA concentration does not exceed that in brain [50,56]; the cord contains HMT [55]. It is also unlikely that the HA in CSF derives from plasma, for, among other reasons, the plasma level is about one-twentieth that of CSF Sources of CSF HA could be the leptomeninges, including the choroid plexus, which has HA-containing mast cells [50,52,[57][58][59][60][61]; the circumventricular organs, which contain mast cells [62] and a high concentration of HA [63]; and mast cells associated with blood vessels [59,64]. Peritoneal mast cells of the rat [65] and neoplastic cells of the mouse do not metabolize histamine, but rather release it [65,66].…”

Section: Discussionmentioning

confidence: 99%

Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasma

et al. 1982

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A gas chromatographic-mass spectrometric method described by us to measure tele-methylhistamine (t-MH) in brain was used to measure t-MH in human cerebrospinal fluid (CSF), urine and plasma. The presence of t-MH in these body fluids was rigorously established. No pros-methyl-histamine could be detected, and it was used as internal standard to quantify t-MH in the fluids. The mean levels of t-MH were: urine, 943 pmol/mg creatinine; plasma, 12.3 pmol/ml; and CSF, 2.2 pmol/ml. Parallel measurements of histamine by a radioenzymatic method showed, respectively, 182 pmol/mg creatinine; 19.5 pmol/ml; and 388 pmol/ml. The levels of HA in CSF, much higher than those of its metabolite, t-MH, are high enough to stimulate HA receptors in the central nervous system.

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Section: Discussionmentioning

confidence: 99%

Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasma

et al. 1982

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“…Mast cell (arrow) in the n. corporis geniculatus lateralis of the tiger, x 1,500. Kruger, 1970], in the hamster [Khlsall, 1966], in the gerbil, kangaroo rat and albino rat [Dropp, 1972], and in some primates, some rodents and the cat [Cammermeyer, 1973], As can be seen in tables VI and VII, mast cells were present alongside blood vessels in some nuclei and tracts of the dorsal thalamus in some species. In adult rodents (albino mice, meadow voles, house mice, pack rats, hooded rats, and albino rats), they were most nu merous and most consistently seen in the n. corporis geniculatis medialis, n. lateralis, n. medialis, n. paraventricularis, n. posterior, n. ventralis, n. dorsalis corporis geniculatus lateralis; and the stria medullaris thalami (Tig.…”

Section: Dorsal Thalamusmentioning

confidence: 99%

“…bush baby, paca], in the n. tegmenti pontis [D r o pp, 1972: kangaroo rat] and in the dentate nucleus [Cammermeyer, 1973: prairie dog, ground squirrel, chimpanzee, cynomolgous monkey]. They have not been reported for other sites in these brain regions.…”

mentioning

confidence: 95%

“…Recently, however, mast cells have been reported in the leptomeninges, in some of the choroid plexuses, in the hypophysis, in the olfactory bulbs, in the supraoptic crest, in the infundibulum, in the subfornical organ, in the area postrema. and in parts of the thalamus and cerebrum in some mammals [for reviews of the literature, O lsson, 1968;Cammermeyer, 1972Cammermeyer, , 1973. Except for the efforts of Kelsall [1966. hamster], Kruger [1970. hedgehog] and Dropp [1972, kangaroo rat, gerbil and albino rat], who studied mast cell distribution throughout the entire brain, studies of mast cells in the brain have been limited to some or only one of the structures listed above.…”

Section: Introductionmentioning

confidence: 99%

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Mast cells in mammalian brain

Dropp¹

1976

Cells Tissues Organs

128

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Mast cells, which had until recently been believed to be not present in the mammalian brain, were studied in the brains of 29 mammalian species. Although there was considerable intraspecific and interspecific variation, mast cells were most numerous within the leptomeninges (especially in those overlying the cerebrum and the dorsal thalamus -most rodents, most carnivores, chimpanzees, squirrel monkeys and elephant), the cerebral cortex (most rodents, tiger, fox, chimpanzee, tarsier, and elephant) and in many nuclei of the dorsal thalamus (most rodents, tiger, lion, and fox). In some mammals, mast cells were also numerous in the stroma of the telencephalic choroid plexuses (chimpanzee, squirrel monkey), the putamen and the claustrum (chimpanzee), the subfornical organ (pack rat, tiger, chimpanzee), the olfactory peduncles (hooded rat, albino rat), the stroma of the diencephalic choroid plexus (lion, chimpanzee, squirrel monkey), the pineal organ (chimpanzee, squirrel monkey), some nuclei of the hypothalamus (tiger), the infundibulum (hooded rat, tiger, fox), the area postrema (pack rat, chinchilla, lion, spider monkey, chimpanzee, fox) and some nuclei and tracts of the metencephalon and the myelencephalon (tiger). Neither the sex of the animal nor electrolytic lesions made in the brains of some of the animals at various times prior to sacrifice appeared to effect the number and the distribution of mast cells. Age-related changes in mast cell number and distribution were detected in the albino rat.

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“…In studies of mast cells in the brains of other mammals [Cammermeyer, 1972[Cammermeyer, . 1973Dropp, 1972Dropp, , 1974Dropp, .…”

Section: Discussionmentioning

confidence: 99%

Mast cells in the human brain

Dropp¹

1979

Cells Tissues Organs

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Mast cells, as adjudged by the metachromatic staining of their cytoplasmic granules, were found in 79% of the 97 human brains studied. They were most numerous and most consistently present in the infundibulum, pineal organ, area postrema and choroid plexuses. They were also numerous in the leptomeninges surrounding the pineal organ and infundibulum. Occasional mast cells were also seen within the supraoptic crest, the subfornical organ, the ventricles and the leptomeninges at sites other than over the infundibulum and pineal organ. They were not detectable elsewhere in the brain or spinal cord. In the infundibulum, pineal organ, area postrema and telencephalic choroid plexuses mast cells were most numerous in young individuals (i.e., 0–19 years of age); thereafter, their numbers progressively decreased with aging. Elsewhere mast cell numbers remained about the same with aging. Except in the area postrema where mast cells were more numerous and more consistently present in males, sex-related differences in mast cell number or distribution were not detected. No differences in either the abundance, the distribution or the percentage of individuals possessing mast cells at any of these sites were apparent between ‘normative’ brains, lesioned brains (‘stroke¹, lobotomy, etc.) or those from individuals with either congenital or acquired encephalopathies.

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Mast cells and postnatal topographic anomalies in mammalian subfornical body and supraoptic crest

Cited by 16 publications

References 50 publications

Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasma

Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasma

Mast cells in mammalian brain

Mast cells in the human brain

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