2018
DOI: 10.1172/jci.insight.123249
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Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS

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Cited by 108 publications
(108 citation statements)
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“…As described previously (Trias et al, , ), only transgenic rats showing weakness and gait alterations in hind limbs as the first clinical sign were selected for masitinib treatment studies. Male rats were divided randomly into the masitinib or vehicle‐treated groups.…”
Section: Methodsmentioning
confidence: 99%
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“…As described previously (Trias et al, , ), only transgenic rats showing weakness and gait alterations in hind limbs as the first clinical sign were selected for masitinib treatment studies. Male rats were divided randomly into the masitinib or vehicle‐treated groups.…”
Section: Methodsmentioning
confidence: 99%
“…Mast cells are also recruited (Esposito, De Santis, Monteforte, & Baccari, ), orchestrating complex vascular and immune cell responses, including the chemoattraction of phagocytic neutrophils that further contribute to myelin clearance (Lindborg et al, ). In comparison, ALS nerve pathology similarly involves reactive changes in SCs (Keller, Gravel, & Kriz, ) as well as the recruitment of monocytes, macrophages, mast cells, and neutrophils (Chiu et al, ; Trias et al, ; Van Dyke et al, ).Such immune cell infiltration of the peripheral motor pathways in ALS has been linked to both protective and deleterious effects on motor neuron degeneration and disease progression (Nardo et al, ). However, the functional link between SCs and immune cell influx to degenerating peripheral nerves in ALS remains unknown.…”
Section: Introductionmentioning
confidence: 99%
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