Mast Cells and Ethanol Consumption: Interactions in the Prostate, Epididymis and Testis of UChB Rats

Mendes, Leonardo O.; Amorim, João Paulo de Arruda; Teixeira, Giovana Rampazzo; Chuffa, Luiz Gustavo de Almeida; Fioruci, Beatriz Aparecida; Pimentel, Tatiana Aparecida; Mello, W.; Padovani, Carlos Roberto; Pereira, Sérgio Luís da Silva; Martinez, Marcelo; Pinheiro, Patrícia Fernanda Felipe; Oliani, Sônia Maria; Martinez, Francisco Eduardo

doi:10.1111/j.1600-0897.2010.00958.x

Cited by 26 publications

(27 citation statements)

References 45 publications

(101 reference statements)

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“…In the present study, the number of mast cells found in the testis and the epididymis corroborate the study by Mendes et al (2011), which reported no change in the number of mast cells in the testis, but which showed an increase in the total number of degranulated and mast cells in the epididymal UChB of adult rats exposed to ethanol (01:10, v/v) for 100 days. According to Haidl et al (2011), an increase in mast cells in the male reproductive tract may impair fertility.…”

Section: Discussionsupporting

confidence: 95%

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Ethanol exposure during peripubertal period increases the mast cell number and impairs meiotic and spermatic parameters in adult male rats

Punhagui

Vieira

Siervo

et al. 2016

Microsc. Res. Tech.

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Puberty is characterized by psychosomatic alterations, whereas chronic ethanol consumption is associated with morphophysiological changes in the male reproductive system. The purpose of this study was to show the toxic effects on testis and epididymal morphophysiology after ethanol administration during peripuberty. To this end, male Wistar rats were divided into two groups: ethanol (E) group: received a 2 g dose of ethanol/kg in 25% (v/v); and control (C) group: received the same volume of filtered water; both were treated by gavage for 54 days. On the 55th day of the experiment, epididymis, and testis were collected for sperm count, histopathology, mast cell count, and morphometry. The vas deferens was collected for sperm motility analysis. The femur and testicle were used for cytogenetic analysis. Ethanol exposure caused reduction in daily sperm production (DSP) and in sperm motility, multinucleated cells or those having no chromosomal content, and late chromosome migrations. No changes were observed in the number of chromosomes in the mitotic analysis. However, some alterations could be seen in meiocytes at different stages of cell division. Stereological analysis of the epididymis indicated reorganization of its component in the 2A and 5A/B regions. The epididymal cauda had greater recruitment, and both degranulated and full mast cells showed an increase in the initial segment, in the ethanol group. In conclusion, ethanol administration during the pubertal phase affects epididymis and testis in adult rats, as indicated mainly by our new findings related to mast cell number and meiotic impact. Microsc. Res. Tech. 79:541-549, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 95%

“…Mast cell count analysis was performed as described by Mendes et al (2011). Tissue sections were stained with 1% toluidine blue to identify mast cells.…”

Section: Mast Cell Countmentioning

confidence: 99%

Ethanol exposure during peripubertal period increases the mast cell number and impairs meiotic and spermatic parameters in adult male rats

Punhagui

Vieira

Siervo

et al. 2016

Microsc. Res. Tech.

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“…32 The high number of degranulated mast cells in the EtOH confirmed this process already described by Mendes et al 33 The increase of intact and degranulated mast cells observed in T could be attributed to a high expression of IL-10 in the prostate, because this cytokine is proposed to stimulate the proliferation of mast cells. 34 In addition to the indirect effects caused by ethanol (e.g., decreasing plasma testosterone and triggering hormonal imbalance) 35,36 , some authors suggest a direct action based on the hypothesis that prostate is able to metabolizes ethanol to acetaldehyde which leads to the generation of free radicals and a subsequent oxidative stress in the organ.…”

Section: Discussionsupporting

confidence: 78%

Testosterone Therapy Differently Regulates the Anti‐ and Pro‐Inflammatory Cytokines in the Plasma and Prostate of Rats Submitted to Chronic Ethanol Consumption (UChB)

Mendes

Scarano

Rochel-Maia³

et al. 2014

American J Rep Immunol

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“…It has been reported that chronic alcohol and cigarette consumption can lead to a malfunction of accessory glands2021. Our results suggest a late short-term negative impact of the acute lifestyle changes on both epididymal and accessory sex glands function, which is also reflected by a reduction on semen volume throughout the TPs.…”

Section: Discussionsupporting

confidence: 49%

Study on the short-term effects of increased alcohol and cigarette consumption in healthy young men’s seminal quality

Cruz

Gomes

Correia

et al. 2017

Sci Rep

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Many studies have reported a negative impact of lifestyle factors on testicular function, spermatozoa parameters and pituitary-gonadal axis. However, conclusions are difficult to draw, since studies in the general population are rare. In this study we intended to address the early and late short-term impact of acute lifestyle alterations on young men’s reproductive function. Thirty-six healthy male students, who attended the Portuguese academic festivities, provided semen samples and answered questionnaires at three time-points. The consumption of alcohol and cigarette increased more than 8 and 2 times, respectively, during the academic festivities and resulted in deleterious effects on semen quality: one week after the festivities, a decrease on semen volume, spermatozoa motility and normal morphology was observed, in parallel with an increase on immotile spermatozoa, head and midpiece defects and spermatozoa oxidative stress. Additionally, three months after the academic festivities, besides the detrimental effect on volume, motility and morphology, a negative impact on spermatozoa concentration was observed, along with a decrease on epididymal, seminal vesicles and prostate function. This study contributed to understanding the pathophysiology underlying semen quality degradation induced by acute lifestyle alterations, suggesting that high alcohol and cigarette consumption are associated with decreased semen quality in healthy young men.

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Mast Cells and Ethanol Consumption: Interactions in the Prostate, Epididymis and Testis of UChB Rats

Abstract: Ethanol increases the number of total and degranulated mast cells in the prostate and epididymis, as well as associated with increasing MMC, and therefore, it could be leading to inflammation in these organs.

Cited by 26 publications

References 45 publications

Ethanol exposure during peripubertal period increases the mast cell number and impairs meiotic and spermatic parameters in adult male rats

Ethanol exposure during peripubertal period increases the mast cell number and impairs meiotic and spermatic parameters in adult male rats

Testosterone Therapy Differently Regulates the Anti‐ and Pro‐Inflammatory Cytokines in the Plasma and Prostate of Rats Submitted to Chronic Ethanol Consumption (UChB)

Study on the short-term effects of increased alcohol and cigarette consumption in healthy young men’s seminal quality

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