Mast Cell Tryptase Stimulates DLD-1 Carcinoma Through Prostaglandin- and MAP Kinase-Dependent Manners

Yoshii, Masanori; Jikuhara, Atsushi; Mori, Shuji; Ishibashi, Hiromi; Takahashi, Hideo; Nishibori, Masahiro; Tanaka, Noriaki

doi:10.1254/jphs.fpj05002x

Cited by 40 publications

(42 citation statements)

References 30 publications

(20 reference statements)

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“…The result of the literature review is summarized in Tables 1, 2, 3, and 4, (Arora et al 2008;Beaulieu and Church 2007;Bromberg et al 2001;Caruso et al 2006;Cooper et al 2003;Elzer et al 2008;Fujimoto et al 2006;Ghio et al 2006;Granovsky-Grisaru et al 2006;Hazarika et al 2004;Hjortoe et al 2004;Ikeda et al 2003Ikeda et al , 2006Jahan et al 2007;Jin et al 2003;Kang et al 2003;Kaufmann et al 1998Kaufmann et al , 1999Kaufmann et al , 2000Kim et al 2002;Massi et al 2005;Matej et al 2007;Miyata et al 2000;Mize et al 2008;Ohta et al 2003;Okamoto et al 2001;Radjabi et al 2008;Rudroff et al 2002;Sánchez-Hernández et al 2008;Seo et al 2007;Shibata et al 2004;Yoshii et al 2005;Zhang et al 2004). …”

Section: Resultsmentioning

confidence: 99%

Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer

Elste

Petersen

2010

J Mol Hist

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Proteinase activated receptors (PAR 1-4) are membrane receptors with a unique way of activation by proteinases like thrombin, trypsin and matrix metalloproteinases which lead to a specific cellular response. To evaluate the significance of expression and co-expression of PAR in cancer we performed a survey on published data. A Pubmed literature search on "PAR, thrombin, cancer" was performed and 46 publications were selected for systematic review based on the availability of information on tumor type, material type, detection method and specification of positive cases. PAR-1 was found in 77.3% of malignant samples (n = 678), PAR-2 in 79.5% (n = 592), PAR-3 in 12.6% (n = 87) and PAR-4 in 54.9% (n = 153). PAR-1 and -2 were present in adenocarcinomas, melanomas, osteosarcomas, glioblastomas, meningiomas, leukaemias and squamous cell carcinomas. Presence of PAR-3 was limited to kidney and liver cancer. The data on PAR-4 expression was inconclusive. Those studies analysing PAR-1 and PAR-2 reported coexpression of the two receptors. PAR-1 and -2 are widely expressed in human tumors suggesting an important role in tumorigenesis and providing potential targets for therapy. PAR-3 and PAR-4 are less frequently detectable, their expression and potential role in tumorigenesis require further investigation.

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Section: Resultsmentioning

confidence: 99%

Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer

Elste

Petersen

2010

J Mol Hist

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“…This activity of mast cells has been theorized to be due to the production of tryptase, which is reported to promote proliferation of colon cancer cells, fibroblasts, and other cell types (Yoshii et al 2005;Cairns and Walls 1996;Berger et al 2001;Gruber et al 1997;Levi-Schaffer and Piliponsky 2003;Frungieri et al 2002). Mast cell histamine has also been suggested to play a role in tumor cell proliferation; however, the literature is not in agreement with whether it promotes or suppresses proliferation (Theoharides and Conti 2004).…”

Section: Mast Cells In Prostate Cancermentioning

confidence: 99%

The Role of Inflammation in Prostate Cancer

Sfanos

Hempel

Marzo

2014

Advances in Experimental Medicine and Biology

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In the United States and in "Westernized" countries, the prevalence of both prostate cancer and prostate inflammation is very high, indicating that the two pathologies could be causally related. Indeed, chronic inflammation is now regarded as an "enabling" characteristic of human cancer. Prostate cancer incidence is thought to be mediated in part by genetics, but also by environmental exposures, including the same exposures that may contribute to the development of prostatic inflammation. As our understanding of the role of inflammation in cancer deepens, it is increasingly apparent that "inflammation" as a whole is a complex entity that does not always play a negative role in cancer etiology. In fact, inflammation can play potentially dichotomous (both pro and antitumorigenic) roles depending on the nature and the cellular makeup of the immune response. This chapter will focus on reviewing the current state of knowledge on the role of innate and adaptive immune cells within the prostate tumor microenvironment and their seemingly complex role in prostate cancer in preventing versus promoting initiation and progression of the disease.

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“…PAR-2 activation regulates gut motility [148], interrupts E-cadherin, and compromises epithelial barrier functions [149]. PAR2 activity also simulates proliferation of colon cancer cells [150] and induces the expression of the prostaglandin-synthesizing enzyme COX2 and its metabolite prostaglandin-E2 [150], a potent immune-suppressive and tumor mitogenic soluble mediator. Overall consensus is that activation of PAR2 is an oncogenic event in colon cancer [151].…”

Section: Contribution Of Mast Cells To Tumor Proliferation and Invasionmentioning

confidence: 99%

The significant role of mast cells in cancer

Khazaie

Blatner

Khan

et al. 2011

Cancer Metastasis Rev

187

180

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Mast cells (MC) are a bone marrow-derived, long-lived, heterogeneous cellular population that function both as positive and negative regulators of immune responses. They are arguably the most productive chemical factory in the body and influence other cells through both soluble mediators and cell-to-cell interaction. MC are commonly seen in various tumors and have been attributed alternatively with tumor rejection or tumor promotion. Tumor-infiltrating MC are derived both from sentinel and recruited progenitor cells. MC can directly influence tumor cell proliferation and invasion but also help tumors indirectly by organizing its microenvironment and modulating immune responses to tumor cells. Best known for orchestrating inflammation and angiogenesis, the role of MC in shaping adaptive immune responses has become a focus of recent investigations. MC mobilize T cells and antigen-presenting dendritic cells. They function as intermediaries in regulatory T cells (Treg)-induced tolerance but can also modify or reverse Treg-suppressive properties. The central role of MC in the control of innate and adaptive immunity endows them with the ability to tune the nature of host responses to cancer and ultimately influence the outcome of disease and fate of the cancer patient.

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Mast Cell Tryptase Stimulates DLD-1 Carcinoma Through Prostaglandin- and MAP Kinase-Dependent Manners

Cited by 40 publications

References 30 publications

Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer

Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer

The Role of Inflammation in Prostate Cancer

The significant role of mast cells in cancer

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