Mast cell phenotypes and microvessels in non–small cell lung cancer and its prognostic significance

Carlini, Maria J.; Dalurzo, Mercedes; Lastiri, José; Smith, David; Vasallo, Bartolomé; Puricelli, Lydia; Cidre, Lilia Susana Lauría de

doi:10.1016/j.humpath.2009.04.029

Cited by 80 publications

(78 citation statements)

References 31 publications

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“…However, although there was an increased density of CD31 + endothelial cells in patients with OSCC, this did not correlate with disease recurrence. This is partly in accordance with previous OSCC studies on vessel density, showing diverse prognostic significance (31,32).…”

Section: Stromal Cells (Red Arrows) At the Invasive Front Of Carcinsupporting

confidence: 92%

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma

Attramadal

Kumar

Gao

et al. 2016

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Abstract. Background: The cellular composition of the tumor microenvironment (TME) at the invading front of oral squamous cell carcinomas (OSCCsThe growth of oral squamous cell carcinoma cells is influenced by its stroma. Stromal cells such as mast cells (MCs), cancer-associated fibroblasts (CAFs), tumorassociated macrophages (TAMs), endothelial cells, pericytes, smooth muscle cells and lymphocytes promote tumor growth, local infiltration, proliferation, neovascularization and escape from immune defense (1). Such cancer-amended stroma is referred to as the tumor microenvironment (TME) (2), and is probably as important as the cancer itself in facilitating cancer cell invasion and metastasis. In the current study of early-stage oral squamous cell carcinomas (OSCCs), we examined the significance of MCs, CAFs, TAMs and endothelial cells in the TME of the invasive front, and their influence on disease recurrence. The MC findings were further explored in a larger cohort of patients with head and neck squamous cell carcinoma.MCs are especially present in surface mucosa such as the skin, bronchial tract, lungs and digestive tract, conjunctiva, nose and mouth, and are best known for their role in allergic immune reactions (3). The TME in OSCC contains more MCs than normal oral mucosa (4), but their role in TME is intricate and poorly understood. These MCs may promote cancer growth by stimulating angiogenesis and tissue remodeling, but also exert anticancerous effects, depending on cofactors and cell location (5).CAFs represent a common functional state of cancerstimulated mesenchymal cells. Their cell of origin is 5499

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Section: Stromal Cells (Red Arrows) At the Invasive Front Of Carcinsupporting

confidence: 92%

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma

Attramadal

Kumar

Gao

et al. 2016

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“…Studies correlating the presence of mast cells in prostate cancer (76)(77)(78), colorectal cancer (79)(80)(81)(82)(83)(84) and non-small cell lung cancer (32,(85)(86)(87)(88) have led to more nuanced interpretations. In prostate cancer, Nonomura and colleagues reported that the number of tryptase þ mast cells (that in this study were only observed around but not within the cancer foci) positively correlated with a high Gleason score and an advanced clinical stage of the prostate tumor, indicating that high numbers of such mast cells represent a poor prognostic factor for survival following treatment (76).…”

Section: Studies Linking Mast Cells To Tumors In Humansmentioning

confidence: 99%

Mast Cells: Potential Positive and Negative Roles in Tumor Biology

Marichal

Tsai

Galli

2013

Cancer Immunology Research

149

150

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Mast cells are immune cells that reside in virtually all vascularized tissues. Upon activation by diverse mechanisms, mast cells can secrete a broad array of biologically active products that either are stored in the cytoplasmic granules of the cells (e.g., histamine, heparin, various proteases) or are produced de novo upon cell stimulation (e.g., prostaglandins, leukotrienes, cytokines, chemokines, and growth factors). Mast cells are best known for their effector functions during anaphylaxis and acute IgE-associated allergic reactions, but they also have been implicated in a wide variety of processes that maintain health or contribute to disease. There has been particular interest in the possible roles of mast cells in tumor biology. In vitro studies have shown that mast cells have the potential to influence many aspects of tumor biology, including tumor development, tumor-induced angiogenesis, and tissue remodeling, and the shaping of adaptive immune responses to tumors. Yet, the actual contributions of mast cells to tumor biology in vivo remain controversial. Here, we review some basic features of mast cell biology with a special emphasis on those relevant to their potential roles in tumors. We discuss how using in vivo tumor models in combination with models in which mast cell function can be modulated has implicated mast cells in the regulation of host responses to tumors. Finally, we summarize data from studies of human tumors that suggest either beneficial or detrimental roles for mast cells in tumors. Cancer Immunol Res; 1(5); 269-79. Ó2013 AACR. Disclosure of Potential Conflicts of InterestNo potential conflicts of interest were disclosed.

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“…Other authors have parallely investigated the presence of MC T , MC C and MC TC and have demonstrated a correlation between their number and microvascular density in uterine cervix cancer (Cabanillas-Saez et al, 2002;Wilk et al, 2010), gastric cancer (Ribatti et al, 2010) and in non small cell lung cancer (Carlini et al, 2010).…”

Section: A B C Dmentioning

confidence: 99%

Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay

et al. 2011

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Human mast cells (MCs) are divided in two types depending on the expression of tryptase and chymase in their granules. Literature data indicate that both tryptase and chymase are angiogenic, but there is currently no evidence of their direct angiogenic activity in vivo. In this study, we have investigated the capacity of tryptase and chymase to promote vasoproliferation in chick embryo chorioallantoic membrane (CAM), a well established in vivo assay to study angiogenesis and anti-angiogenesis. The results showed that both tryptase and chymase stimulate angiogenesis and that the response is similar to that obtained with vascular endothelial growth factor (VEGF), a well-known angiogenic cytokine, and confirm the angiogenic activity of these two proteases stored in MC granules.

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Mast cell phenotypes and microvessels in non–small cell lung cancer and its prognostic significance

Cited by 80 publications

References 31 publications

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma

Mast Cells: Potential Positive and Negative Roles in Tumor Biology

Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay

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