Mast‐cell phenotype in urticaria

Nettis, Eustachio; Dambra, Porzia; Loria, M. P.; Cenci, Lorenzo; Ga, Veña; Ferrannini, A.; Tursi, A.

doi:10.1034/j.1398-9995.2001.00296.x

Cited by 34 publications

(27 citation statements)

References 4 publications

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“…Increased mast cell numbers in both lesional and non‐lesional skin have been reported in several other studies, while others report increases in areas of whealing or recent whealing or in both lesional and uninvolved skin of patients with prolonged (>10 weeks) disease . One study which compared mast cell subtypes in lesional skin of CSU patients and healthy skin is particular noteworthy . This study showed that there are no differences between the numbers of MC TC , the so‐called connective tissue mast cell, between the 2 groups.…”

Section: Mast Cell Location and Changes In Number In Chronic Urticariasupporting

confidence: 55%

The role and relevance of mast cells in urticaria

Church

Kolkhir

Metz

et al. 2018

Immunological Reviews

214

198

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This review presents evidence that the skin mast cell, in particular the MC subtype, is the primary effector cell in urticaria. Mast cells are located in the upper dermis, the ideal situation for wheal formation and sensory nerve stimulation. Increased numbers of mast cells are found in both lesional and non-lesional skin in CSU and inducible urticaria. Mast cell degranulation in the area of wheals has been demonstrated repeatedly by light and electron microscopy. Histamine, PGD and tryptase are found in the venous blood draining wheal formation. The last 2 are specific for mast cells rather than basophils. Mast cell reactivity is increased in active urticaria by local inflammatory cytokines and neuropeptides. Mast cell cytokines and neuropeptides, particularly nerve growth factor, induce a Th2 type inflammation that is particularly obvious at the sites of whealing. In conclusion, autoimmunity, either of Type 1 viz. IgE antibodies to local autoallergens, or Type 2b, viz. IgG autoantibodies to IgE or its receptor, are considered to be the most frequent causes of CSU. In both cases, the mast cell is likely to be the axial cell in producing the wheals.

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Section: Mast Cell Location and Changes In Number In Chronic Urticariasupporting

confidence: 55%

The role and relevance of mast cells in urticaria

Church

Kolkhir

Metz

et al. 2018

Immunological Reviews

214

198

View full text Add to dashboard Cite

show abstract

“…The source of IL-6 in CU has not been identified. Mast cells and other inflammatory cells types identified in skin biopsies of CU patients, including monocytes, basophils, eosinophils, activated T cells, and neutrophils release this cytokine [8, 9, 16, 17]. It has been suggested that IL-6 is involved in pathogenesis of severe acute urticaria, resistant to conventional antihistamine treatment [18].…”

Section: Discussionmentioning

confidence: 99%

Study of serum interleukin (IL) 18 and IL-6 levels in relation with the clinical disease severity in chronic idiopathic urticaria patients of Kashmir (North India)

Rasool

Ashiq

Shera

et al. 2014

Asia Pacific Allergy

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BackgroundChronic urticaria is termed as idiopathic if there is an absence of any identifiable causes of mast cell and basophil degranulation. Various cytokines have been found to be involved in inflammatory processes associated with chronic idiopathic urticaria, including interleukin (IL) 18 and IL-6.ObjectiveTo evaluate any possible correlation of IL-18 and IL-6 cytokines with the clinical disease severity in chronic idiopathic urticaria (CIU).MethodsIL-18 and IL-6 levels of CIU patients (n = 62) and healthy controls (n = 27) were assessed by commercially available enzyme linked immunosorbent assay kits following the manufacturer's protocols.ResultsSerum IL-18 concentration (mean ± standard deviation [SD], 62.95 ± 36.09 pg/mL) in CIU patients and in healthy controls (54.35 ± 18.45 pg/mL) showed no statistical significance (p > 0.05). No statistically significant difference (p > 0.05) was observed between autologous serum skin test (ASST) positive and ASST negative patients with regard to the serum IL-18 levels either. Similarly, serum IL-6 concentration (0.82 ± 4.6 pg/mL) in CIU patients and in healthy controls (0.12 ± 1.7 pg/mL), showed no statistical significance (p > 0.05). Also, comparison between positive and ASST negative patients with regard to the serum IL-6 levels was statistically nonsignificant (p > 0.05). However, statistical significance was found both in IL-18 and IL-6 concentrations in certain grades with regard to the clinical disease severity of urticaria.ConclusionThere is no significant association as such found between IL-18 and IL-6 levels with CIU, however, these cytokines may help in predicting the clinical disease severity in CIU. Hence, these cytokines may indicate a potential role as a biomarker to assess the disease severity in CIU.

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“…Similar studies were also carried out on patients with CU, and these revealed the same evidence of increased numbers of mast cells versus the normal skin biopsy findings in the control group. 16,17 In another trial related to the skin biopsies of patients with FM, Salemi et al 18 showed that a high proportion of the patients had increased immunoreactivity for tumor necrosis factor alpha (TNF-a) in the biopsy specimens. Similarly, Hermes et al 19 demonstrated that there was a high immunoreactivity for TNF-a in all types of urticaria, whereas none of the control patients had an immunohistochemical expression of TNF-a in the biopsy specimens.…”

Section: Discussionmentioning

confidence: 99%

“…23 Furthermore, some authors have suggested that there is a reduced capability to enhance the sympathetic activity in vessels due to the autonomic dysfunction in patients with FM. 20,21 The pathogenesis of CU and FM is still unknown, 17,37 but it is difficult to claim that CU and FM originate from the same etiopathogenesis. Furthermore, this study did not aim to prove such a claim; however, we still noticed remarkable similarities between the two diseases.…”

Section: Discussionmentioning

confidence: 99%

“…13,14 Some pathological changes have been described in the skin biopsies of patients with FM as resembling the cellular and cytokine involvement in the biopsy specimens of patients with CU. [15][16][17][18][19] In addition, it has been suggested that there is an autonomic dysfunction in patients with FM and CU, and sympathomimetic amines may lead to improvement in the symptoms of the two diseases when there is a resistance to conventional therapies. [20][21][22][23] Taking into account all of this information, we investigated whether patients with CU are also affected by FM.…”

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confidence: 99%

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Is There An Association Between Chronic Urticaria and Fibromyalgia Syndrome?

et al. 2014

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Objectives: Chronic urticaria (CU) and fibromyalgia (FM) are different types of diseases with unclear etiopathogeneses but share many clinical and histochemical features. This study aims to make a recognization on these features and examines whether patients with CU are also affected by FM. Patients and methods:Forty patients with CU and 38 healthy controls were enrolled to this study. All of the participants were assessed according to the 1990 American College of Rheumatology (ACR) classification criteria for FM and asked questions regarding the clinical features of FM. The quality of life was assessed by the Nottingham Health Profile (NHP), while the psychological status was evaluated using the Hospital Anxiety and Depression Scale (HADS). Results:The incidence of FM was higher among the patients with CU (32.5%) than the controls (10.5%) (p=0.019). We indicated that the patients with CU suffered restrictions regarding to quality of life as assessed by the NHP. NHP-sleep (p=0.035), NHP-social isolation (p=0.032) and NHP-emotional reaction (p=0.027) scores were significantly higher compared to HCs. The HADS-depression scores were also significantly higher in the patients with CU (p=0.006). The patients with CU and concomitant FM had higher total NHP scores than those without FM (p<0.001). Conclusion:Clinicians must be alerted to the possible coexistence of FM in CU patients. Patients with CU have higher rates of FM than the general population and this results in more restrictions in daily life in these patients than those with CU alone. Therefore, additional treatment protocols may be required to be implicated for the treatment of patients with both CU and FM.

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Mast‐cell phenotype in urticaria

Cited by 34 publications

References 4 publications

The role and relevance of mast cells in urticaria

The role and relevance of mast cells in urticaria

Study of serum interleukin (IL) 18 and IL-6 levels in relation with the clinical disease severity in chronic idiopathic urticaria patients of Kashmir (North India)

Is There An Association Between Chronic Urticaria and Fibromyalgia Syndrome?

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