Mast Cell-Nerve Interactions

Bauer, Omri; Razin, Ehud

doi:10.1152/physiologyonline.2000.15.5.213

Cited by 75 publications

(84 citation statements)

References 15 publications

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“…It has also been reported that MCs are localized near the SP-positive neurons where SP promotes the release of histamine [64]. Ghrelin-positive MCs localization near the autonomic nerves in the rat stomach wall correlates with results detecting MCs near the peptidergic nerves in other organs and species [23][24][25]. According to earlier studies, the neuropeptides can influence the secretion of MC cytokines which exert their modulatory effect in neurogenic inflammation [66][67][68].…”

Section: Resultssupporting

confidence: 61%

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Distribution of ghrelin-positive mast cells in rat stomach

Stefanov

Ananiev

Ivanova

et al. 2017

Biotechnology & Biotechnological Equipment

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It is known that the gastrointestinal peptide hormone ghrelin is expressed in human and rodent B lymphocytes, T lymphocytes, monocytes and natural killer cells. However, there are no data about ghrelin expression by mast cells. These facts, as well as the common progenitor cells of mast cells and the above-mentioned immune cells, motivated us to undertake the current work in order to prove that like other granulocytes, rat gastric mast cells are capable of immunohistochemical expression of ghrelin. Gastric wall sections of Wistar rats were studied immunohistochemically for detection of ghrelin and tryptase and histochemically for toluidine blue in order to identify ghrelinpositive mast cells as well as to establish their localization and distribution. Results showed that mast cell granules expressed ghrelin. The ghrelin-positive mast cells were the least numerous as compared to tryptase-positive mast cells and toluidine blue-positive mast cells. Based on the observed expression of ghrelin in granules of mast cells localized in the rat gastric wall, we suggested that this type of cell can be regarded as an important source of ghrelin and suggested that ghrelin may exert different physiological functions, such as regulation of muscular, epithelial and glandular functions.

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Section: Resultssupporting

confidence: 61%

“…MC secreting histamine, substance P (SP), vasoactive intestinal polypeptide (VIP) and other factors are mobile that make contact with peptidergic nerve endings (secreting also SP, VIP, etc.) in tissues and maintain in this way tissue homeostasis and participating in arising inflammation [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Distribution of ghrelin-positive mast cells in rat stomach

Stefanov

Ananiev

Ivanova

et al. 2017

Biotechnology & Biotechnological Equipment

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“…M ast cells in the CNS are located on the brain side of the blood-brain barrier (BBB). Mast cells can potentially mediate neurotransmission, neurite outgrowth, and neuronal survival in the brain (1,2). Mast cells are associated with various physiological and pathophysiological conditions, such as the estrus cycle, behavior, vascular headaches, and multiple sclerosis (MS) (3).…”

mentioning

confidence: 99%

Signaling Pathways in the Activation of Mast Cells Cocultured with Astrocytes and Colocalization of Both Cells in Experimental Allergic Encephalomyelitis

Kim

Jeoung

2010

The Journal of Immunology

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“…16 -21 Afferent nerves express specific receptors for neuropeptides, 22 prostaglandins, 23 histamine, 24 proteases, 25 neurotrophins, 26 and cytokines, 27,28 and mast cells can also respond to many of these products. 1,2,15,29,30 Moreover, certain adhesion molecules, such as N-cadherin 31 and spermatogenic Ig superfamily/ synaptic cell adhesion molecule, 32 have been shown to be important in mediating interactions between nerves and mast cells.…”

mentioning

confidence: 99%

Mast Cell-Derived Tumor Necrosis Factor Can Promote Nerve Fiber Elongation in the Skin during Contact Hypersensitivity in Mice

Kakurai

Monteforte

Suto

et al. 2006

The American Journal of Pathology

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In humans, lesions of contact eczema or atopic dermatitis can exhibit increases in epidermal nerves, but the mechanism resulting in such nerve elongation are not fully understood. We found that contact hypersensitivity reactions to oxazolone in mice were associated with significant increases in the length of nerves in the epidermis and dermis. Using genetically mast cell-deficient c-kit mutant mice selectively repaired of their dermal mast cell deficiency with either wild-type or tumor necrosis factor (TNF)-deficient mast cells, we found that mast cells, and mast cell-derived TNF, significantly contributed to the elongation of epidermal and dermal PGP 9.5 ؉ nerves and dermal CGRP ؉ nerves, as well as to the inflammation observed at sites of contact hypersensitivity in response to oxazolone. Moreover, the percentage of mast cells in close proximity to dermal PGP 9.5 ؉ nerve fibers was significantly higher in wild-type mice and in c-kit mutant mice repaired of their dermal mast cell deficiency by the adoptive transfer of wild-type mast cells than in TNF-deficient mice or in TNF ؊/؊ mast cell-engrafted c-kit mutant mice. These observations show that mast cells, and mast cell-derived TNF, can promote the elongation of cutaneous nerve fibers during contact hypersensitivity in the mouse.

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Mast Cell-Nerve Interactions

Cited by 75 publications

References 15 publications

Distribution of ghrelin-positive mast cells in rat stomach

Distribution of ghrelin-positive mast cells in rat stomach

Signaling Pathways in the Activation of Mast Cells Cocultured with Astrocytes and Colocalization of Both Cells in Experimental Allergic Encephalomyelitis

Mast Cell-Derived Tumor Necrosis Factor Can Promote Nerve Fiber Elongation in the Skin during Contact Hypersensitivity in Mice

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