Mast Cell Function and Death in Trypanosoma cruzi Infection

Meuser-Batista, Marcelo; Corrêa, José R.; Carvalho, Vinícius Frias; Britto, Constança; Moreira, Otacílio C.; Batista, Marcos Meuser; Soares, Maurílio J.; Filho, Francisco Alves Farias; Silva, Patricia Machado R. e; Lannes-Vieira, Joseli; Coutinho‐Silva, Robson; Henriques-Pons, Andréa

doi:10.1016/j.ajpath.2011.06.014

Cited by 20 publications

(12 citation statements)

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“…Nonetheless, peritoneal macrophages from infected mice also show decreased expression of P2X7 [52]. There is still little information on how extracellular ATP or P2X receptors contribute to the immune response against T. cruzi infection, but recent studies describing in vivo infection in P2X7-deficient animals showed an effect of P2X7 on migration of mast cells towards the inflamed heart [53], which may reduce the innate immune response. Our data showing reduced mast cell infiltration in the lungs of P2X7-deficient animals following LPS injection [54] support the analysis of T. cruzi infection and suggest that mast cells could play a major role in controlling infection by intracellular parasites through modulation of inflammation, which was not fully appreciated previously in the literature.…”

Section: Extracellular Nucleotides As Sensors For the Presence Of mentioning

confidence: 99%

Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites

Coutinho‐Silva

Ojcius

2012

Microbes and Infection

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Extracellular nucleotides are danger signals involved in recognition and control of intracellular pathogens. They are an important component of the innate immune response against intracellular pathogens, inducing the recruitment of inflammatory cells, stimulating secretion of cytokines, and producing inflammatory mediators such as reactive oxygen species (ROS) and nitric oxide (NO). In the case of extracellular ATP, some of the immune responses are mediated through activation of the NLRP3 inflammasome and secretion of the cytokine, interleukin-1β (IL-1β), through a mechanism dependent on ligation of the P2X7 receptor. Here we review the role of extracellular nucleotides as sensors of intracellular bacteria and protozoan parasites, and discuss how these pathogens manipulate purinergic signaling to diminish the immune response against infection.

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Section: Extracellular Nucleotides As Sensors For the Presence Of mentioning

confidence: 99%

Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites

Coutinho‐Silva

Ojcius

2012

Microbes and Infection

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“…One animal study showed that T. cruzi -infected CBA mice treated with cromolyn (a MC stabilizer) presented much greater parasitemia and IFN-γ levels, higher mortality, myocarditis, and cardiac damage, indicating that MCs control blood and tissue parasitemia, IFN-γ production, cardiac inflammation, and susceptibility to infection, suggesting that MCs are involved in resistance to this infection (36). …”

Section: Mcs In Trypanosoma Spp Infectionmentioning

confidence: 99%

The Roles of Mast Cells in Parasitic Protozoan Infections

Huang

2017

Front. Immunol.

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Protozoan parasites such as Plasmodium spp., Leishmania spp., Trypanosoma spp., and Toxoplasma gondii are major causes of parasitic diseases in both humans and animals. The immune system plays a critical role against protozoa, but their immune mechanism remains poorly understood. This highlights the need to investigate the function of immune cells involved in the process of parasite infections and the responses of host immune system to parasite infections. Mast cells (MCs) are known to be central players in allergy and anaphylaxis, and it has been demonstrated that MCs have crucial roles in host defense against a number of different pathogens, including parasites. To date, there are many studies that have examined the interaction of helminth-derived antigens and MCs. As one of the major effector cells, MCs also play an important role in the immune response against some parasitic protozoa, but their role in protozoan infections is, however, less well characterized. Herein, we review the current knowledge about the roles of MCs and their mediators during infections involving highly pathogenic protozoa including Plasmodium spp., Leishmania spp., Trypanosoma spp., and T. gondii. We offer a general review of the data from patients and experimental animal models infected with the aforementioned protozoa, which correlate MCs and MC-derived mediators with exacerbated inflammation and disease progression as well as protection against the parasitic infections in different circumstances. This review updates our current understanding of the roles of MCs during parasitic protozoan infections, and the participation of MCs in parasitic protozoan infections could be of a potential therapeutic target.

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“…Macrophages are very important to control the infection, producing nitric oxide (NO) that limits the burden of intracellular parasites. Mast cells are also very important in this scenario and we have recently published that infected CBA mice treated with cromolyn, a mast cell stabilizer, have much greater parasitemia and IFN-γ levels, and higher mortality rates, myocarditis, and cardiac damage [20].…”

Section: Pathogenesis Of Trypanosoma Cruzi-induced Myocarditismentioning

confidence: 99%