Mast Cell Diseases and Drug Hypersensitivity Reactions

Bonadonna, Patrizia; Zanotti, Roberta; Varani, Alessandro Bisoffi; Pagani, Mauro

doi:10.1007/s40521-017-0130-8

Cited by 3 publications

(7 citation statements)

References 45 publications

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“…Finally, curares drugs such as Vecuronium, pancuronium, and cisatracurium have been less frequently associated with the risk of adverse reactions. 88,89 In SM patients, it is also recommended to avoid potential physical triggers, such as sudden temperature changes, cold fluid infusions, extensive tissue trauma, vigorous skin rubbing, and other mechanical factors. 88 In addition, anxiety can trigger MC degranulation so that patients could be premedicated with sedatives (benzodiazepines) before the surgical procedure.…”

Section: Special Aspectsmentioning

confidence: 99%

“…88 In addition, anxiety can trigger MC degranulation so that patients could be premedicated with sedatives (benzodiazepines) before the surgical procedure. 89 There is no consensus about the routine administration of premedication before anesthesia or its efficacy to prevent or reduce the severity of reactions. Premedication is recommended in patients with previous perioperative anaphylaxis and in general, depending on the individual patient's risk.…”

Section: Special Aspectsmentioning

confidence: 99%

“…Finally, curares drugs such as Vecuronium, pancuronium, and cisatracurium have been less frequently associated with the risk of adverse reactions. 88 , 89 …”

Section: Special Aspectsmentioning

confidence: 99%

“… 88 In addition, anxiety can trigger MC degranulation so that patients could be premedicated with sedatives (benzodiazepines) before the surgical procedure. 89 …”

Section: Special Aspectsmentioning

confidence: 99%

See 3 more Smart Citations

Systemic Mastocytosis: Multidisciplinary Approach

Zanotti¹,

Tanasi²,

Crosera³

et al. 2021

Mediterr J Hematol Infect Dis

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Systemic mastocytosis (SM) is a heterogeneous group of diseases that affect almost exclusively adults and are defined by the proliferation and accumulation of clonal mast cells (MC) in various tissues. Disease subtypes range from indolent to rare but aggressive forms. Although SM is classified as a rare disease, it is believed to be likely underdiagnosed. Major signs and symptoms mainly depend on MC activation and less frequently to organ infiltration, typical of more aggressive variants. Diagnosis may be challenging, and symptoms can be aspecific and involve several organs. It is advisable to refer patients to specialized centers, having sufficient knowledge of the disease, sensitive diagnostic procedures, offering a personalized and multidisciplinary diagnostic approach, including at least hematological, allergological, dermatological and rheumatological evaluations. A precise and timely diagnosis is required for: a) adequate counseling of patients and their physicians; b) beginning of symptomatic treatment (anti-mediator therapy); c) prevention of severe manifestations of the disease (i.e., recurrent anaphylaxis, osteoporosis and bone fractures); d) cytoreductive treatment of advanced SM variants. This review aims to summarize the main manifestations of the disease and describe the ideal diagnostic approach for adult patients with suspected SM, giving physicians the main notions for correct patient diagnosis and management. This review also highlights the importance of a multidisciplinary approach in this very complex disease.

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Section: Special Aspectsmentioning

confidence: 99%

Section: Special Aspectsmentioning

confidence: 99%

“…Finally, curares drugs such as Vecuronium, pancuronium, and cisatracurium have been less frequently associated with the risk of adverse reactions. 88 , 89 …”

Section: Special Aspectsmentioning

confidence: 99%

“… 88 In addition, anxiety can trigger MC degranulation so that patients could be premedicated with sedatives (benzodiazepines) before the surgical procedure. 89 …”

Section: Special Aspectsmentioning

confidence: 99%

See 2 more Smart Citations

Systemic Mastocytosis: Multidisciplinary Approach

Zanotti¹,

Tanasi²,

Crosera³

et al. 2021

Mediterr J Hematol Infect Dis

Self Cite

View full text Add to dashboard Cite

show abstract

“…Postępowanie takie jest uznawane za bezpieczne, w odróżnieniu od stosowania tzw. klasycznych NLPZ, takich jak kwas acetylosalicylowy [12]. Przedstawiony w niniejszej pracy chory przyjmował przewlekle feksofenadynę w jednorazowej dawce dobowej 180 mg. Z uwagi na obserwowane w przeszłości objawy wstrząsu anafilaktycznego po zastosowaniu zarówno NLPZ, takich jak ketoprofen i ibuprofen, jak i paracetamolu oraz metamizolu, a także nietolerancję morfiny, zdecydowano o optymalizacji leczenia przeciwbólowego poprzez zwiększenie dawki dotychczas stosowanego przez chorego opioidu -oksykodonu, oraz zastąpieniu gabapentyny pregabaliną.…”

Section: Omówienieunclassified

Fentanyl buccal tablet for the treatment of breakthrough pain in systemic mastocytosis – a case study

Zasowska-Nowak¹,

Ciałkowska-Rysz²

2020

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Drugs and Vaccines Hypersensitivity in Children with Mastocytosis

Mori

Crisafulli

Bianchi

et al. 2022

JCM

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Mastocytosis, a heterogeneous mastcell disease, include three different entities: cutaneous mastocytosis, systemic mastocytosis (SM) and mast-cell sarcoma. Tryptase levels can differentiate cutaneous mastocytosis from SM. In mastocytosis, quick onset drug hypersensitivity reactions (DHRs) that are facilitated by mastcell mediators, are investigated in adults. Due to the limited number of children with mastcell disease and increased serum tryptase levels, the role of drugs in this age group is less studied. In this review, we critically assessed relevant papers related with immediate DHRs in children with mastocytosis and discuss practical issues of the management. In childhood mastocytosis, anaphylaxis is frequently idiopathic, and elevated level of basal tryptase, and high burden of disease may increase the risk. Among drugs, antibiotics, NSAIDs and opioids can potentially induce anaphylaxis, anyway avoidance should be recommended only in case of previous reactions. Moreover, vaccinations are not contraindicated in patients with mastocytosis. The risk of severe systemic reactions after drugs intake seems to be extremely low and in general lower in children than in adults. Anyway, studies on this topic especially focusing on children, are missing to state final recommendations.

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Mast Cell Diseases and Drug Hypersensitivity Reactions

Cited by 3 publications

References 45 publications

Systemic Mastocytosis: Multidisciplinary Approach

Systemic Mastocytosis: Multidisciplinary Approach

Fentanyl buccal tablet for the treatment of breakthrough pain in systemic mastocytosis – a case study

Drugs and Vaccines Hypersensitivity in Children with Mastocytosis

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