Mast Cell Disease Assessment by Flow Cytometric Analysis

Acute mast cell leukemia: A rare but highly aggressive hematopoietic neoplasm

“…Notably, MCs usually express CD9, CD25, CD33, CD44, and CD117 ( KIT ) . However a third of MCL cases reported in the literature had a double‐negative CD2/CD25 immunophenotype . In contrast to patients with ISM or ASM where neoplastic MCs express KIT D816V in a high proportion of cases, neoplastic MCs in MCL patients do not display the KIT D816V mutant in nearly 30%‐50% of the cases .…”