Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria

Meyer, Joseph; Gorbach, Alexander M.; Liu, Wei Min; Medic, Nevenka; Young, Michael L.; Nelson, Celeste M.; Arceo, Sarah; Desai, Avanti; Metcalfe, Dean D.; Komarow, Hirsh D.

doi:10.1371/journal.pone.0056773

Cited by 14 publications

(10 citation statements)

References 33 publications

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“…S1 in the Supplementary Appendix), a finding consistent with our previous report on cold urticaria. 20 Immunohistochemical staining of dermal mast-cell tryptase revealed degranulation resulting from vortex challenge that was more prevalent in patients than controls (Fig. 1D).…”

Section: Resultsmentioning

confidence: 96%

Vibratory Urticaria Associated with a Missense Variant inADGRE2

et al. 2016

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SUMMARY Patients with autosomal dominant vibratory urticaria have localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum. We identified a previously unknown missense substitution in ADGRE2 (also known as EMR2), which was predicted to result in the replacement of cysteine with tyrosine at amino acid position 492 (p.C492Y), as the only nonsynonymous variant cosegregating with vibratory urticaria in two large kindreds. The ADGRE2 receptor undergoes autocatalytic cleavage, producing an extracellular subunit that noncovalently binds a transmembrane subunit. We showed that the variant probably destabilizes an autoinhibitory subunit interaction, sensitizing mast cells to IgE-independent vibration-induced degranulation. (Funded by the National Institutes of Health.)

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Section: Resultsmentioning

confidence: 96%

Vibratory Urticaria Associated with a Missense Variant inADGRE2

et al. 2016

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“…However, the highest incidence is observed in people over 40 years old, three times more often in women than in men. RA can be mild, moderate, or severe, and patients can experience pain, heat, and swelling in the disease process [7,8]. The disease is characterized by disorders related to innate immunity in the processes of complement activation by the antigen-antibody complex as well as adaptive immunity, which manifests itself in the immune response against its antigens.…”

Section: Introductionmentioning

confidence: 99%

Infrared Thermography Sensor for Disease Activity Detection in Rheumatoid Arthritis Patients

Pauk

Wasilewska

Ihnatouski

2019

Sensors

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A recent review of thermography studies in rheumatoid arthritis shows limited data about disease activity and mostly focuses on differences between the thermography of rheumatoid arthritis patients and typical subjects. A retrospective study compared patients with high disease activity (n = 50), moderate disease activity (n = 16), and healthy participants (n = 42), taking into account demographic, clinical, laboratory, and thermography parameters. We applied an infrared thermography sensor and a fingers examination protocol. Outcomes included the mean temperature of five fingers of a hand: In static, post-cooling, post-rewarming, the total change in mean temperature of fingers due to cold provocation, the total change in mean temperature of fingers due to rewarming, the area under the cooling curve, the area under the heating curve, the difference between the area under the rewarming and the cooling curve, and temperature intensity distribution maps. For patients with high disease activity, a lower area under the heating curve and a lower difference between the area under the rewarming curve and the cooling curve were observed, as well as a smaller total change in mean temperature due to rewarming, compared to patients with moderate disease activity (p < 0.05). Our study findings could be helpful in patients with an equivocal clinical examination.

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“…Table II also includes overall medication use and severity scaling (0–15) based on frequency and severity of symptoms. (15)…”

Section: Resultsmentioning

confidence: 99%

Dissociation Between History and Challenge in Patients with Physical Urticaria

Komarow

Arceo

Young

et al. 2014

The Journal of Allergy and Clinical Immunology: In Practice

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Background Physical urticaria is a subtype of chronic urticaria induced by a physical stimulus. Objective To evaluate the consistency between a history of physical urticaria and results of challenge testing. Methods Seventy-six subjects, ages 3–77, were referred with the diagnoses of a physical urticaria and were evaluated using challenge testing directed toward the presenting diagnosis, yet included other stimuli based on history. The majority of subjects were tested to 3 or more stimuli, thus 294 provocation tests were performed. Fifty-seven subjects were surveyed for the status of their physical urticaria at least one year after initial evaluation. Results Of the 76 subjects with a positive history of a physical urticaria, 38 %(N=29) were challenge negative to the presenting diagnosis. Eight patients within the challenge negative group reacted positively to additional testing, thus 28 % (N=21) remained negative to all challenge testing, allowing discontinuation of medications and avoidance behavior. A negative challenge result was less likely in subjects presenting with cold induced urticaria (25 %), delayed pressure urticaria (25 %) and dermatographism (29 %), yet more common in cholinergic (65 %) and solar urticaria (67 %). A one-year follow-up survey of 57 subjects was consistent with initial results. Nineteen of this sub-group were rechallenged for the presenting diagnosis and the outcome was unchanged in 17 patients and in two patients the urticaria had resolved. Conclusions The diagnosis by history of a physical urticaria should be verified by testing whenever possible; and particularly if the condition is judged as severe and thus requires both significant life-style changes and pharmacologic intervention.

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Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria

Cited by 14 publications

References 33 publications

Vibratory Urticaria Associated with a Missense Variant inADGRE2

Vibratory Urticaria Associated with a Missense Variant inADGRE2

Infrared Thermography Sensor for Disease Activity Detection in Rheumatoid Arthritis Patients

Dissociation Between History and Challenge in Patients with Physical Urticaria

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