Mast cell density and PGP 9.5‐immunostained nerves in angioleiomyoma: their relationship to painful symptoms

Geddy, P. M.; Gray, Stephen W.; Reid, W. A.

doi:10.1111/j.1365-2559.1993.tb00141.x

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…Neviaser (31) reported a recurrence and malignant transformation 7 years after the initial operation requiring wide local excision. Herren et al (32) reported malignant transformation of an angioleiomyoma in the finger in a 17‐year old, which needed ray excision.…”

Section: Treatmentmentioning

confidence: 99%

Angioleiomyoma: a clinical, pathological and radiological review

Ramesh

Annapureddy

Khan³

et al. 2004

International Journal of Clinical Practice

168

202

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Angioleiomyoma is a benign tumour arising from the vascular smooth muscle (tunica media) and presents commonly between third and fifth decades of life. Although there are sporadic reports about this tumour in the literature, none describes all the information in detail. This review is an attempt to collate all the facts in one concise article. Angioleiomyoma presents as a painful mass in approximately 60% of the cases. One of the distinct clinical feature noted is the increase in size of the swelling with physical activity of the involved part, especially in the hand. It should be considered in the differential diagnosis of painful nodular lesions of the extremity. Pre-operative diagnosis is difficult, but with a high index of suspicion and awareness, it is possible. The use of ultrasound and magnetic resonance imaging should be considered. It causes minimal morbidity and excision is usually curative. Histological examination using smooth muscle Actin stain portraits the smooth muscle bundles clearly.

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Section: Treatmentmentioning

confidence: 99%

Angioleiomyoma: a clinical, pathological and radiological review

Ramesh

Annapureddy

Khan³

et al. 2004

International Journal of Clinical Practice

168

202

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“…Increased numbers of mast cells have been observed in biopsy specimens from about 20% of patients with Type I FIC 76 and IC, 28 and are thought by some to be involved in the pathophysiology of the syndrome 80 . The finding of mast cells in the bladder is by no means specific to these syndromes 81 . The role of mast cells in IC and comorbid disorders, especially those exacerbated by stress, was recently reviewed 82 .…”

mentioning

confidence: 99%

Idiopathic Cystitis in Domestic Cats—Beyond the Lower Urinary Tract

Buffington

2011

Veterinary Internal Medicne

108

102

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Signs of lower urinary tract (LUT) disease in domestic cats can be acute or chronic, and can result from variable combinations of abnormalities within the lumen of the LUT, the parenchyma of the LUT itself, or other organ system(s) that then lead to LUT dysfunction. In the majority of cats with chronic signs of LUT dysfunction, no specific underlying cause can be confirmed after standard clinical evaluation of the LUT, so these cats typically are classified as having idiopathic cystitis. A syndrome in human beings commonly known as interstitial cystitis (IC) shares many features in common with these cats, permitting comparisons between the two species. A wide range of similarities in abnormalities has been identified between these syndromes outside as well as inside the LUT. A variety of potential familial and developmental risk factors also have been identified. These results have permitted generation of the hypothesis that some of these people have a disorder affecting the LUT rather than a disorder of the LUT. This perspective has suggested alternative diagnostic strategies and novel approaches to treatment, at least in cats. The purpose of this review is to summarize research investigations into the various abnormalities present in cats, to compare some of these findings with those identified in human beings, and to discuss how they might modify perceptions about the etiopathogenesis, diagnosis, and treatment of cats with this disease.

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“…The association of nerve involvement with a tumor capsule and pain for angiomyomas has been similarly confirmed in other studies [ 19 ]. More specifically, a study by Geddy et al examined mast cell density in relation to incidents of painful angiomyomas determining that mast cell density was actually decreased in painful lesions, suggesting that mast cell degranulation may have occurred and potential local inflammation contributed to the development of lesion associated pain [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Lateral Femoral Cutaneous Nerve Angiomyoma

Mugge¹,

Dang²,

Chandela³

2021

Cureus

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Angiomyomas are benign tumors derived from smooth muscle cells of vessels. They are principally a pathology of the peripheral nervous system where they involve cutaneous nerves, causing pain and paresthesia. We present a case of a lateral femoral cutaneous nerve angiomyoma and its surgical treatment. A 24-year-old female presented to clinic with right thigh pain in the distribution of the lateral femoral cutaneous nerve, which had been ongoing and progressive for seven months. There was associated numbness and tingling. A lesion was noted in the anterior subcutaneous tissues of the thigh on contrasted CT and MRI. The patient was taken to the operating room where a pearly white lesion was found within the subcutaneous tissue. No effect was seen with stimulation of the lesion. The lesion was removed en bloc, and pathological analysis revealed an angiomyoma. Post-operatively, the patient reported complete resolution of all symptoms, namely, pain and paresthesia. No similar reports were identified within the literature. Together, angiomyomas have been described within the lower extremities to cause pain and paresthesia. This is the first reported case of an angiomyoma involvement within the lateral femoral cutaneous nerve. Complete surgical resection, in this case, was curative and diagnostic.

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Mast cell density and PGP 9.5‐immunostained nerves in angioleiomyoma: their relationship to painful symptoms

Cited by 11 publications

References 28 publications

Angioleiomyoma: a clinical, pathological and radiological review

Angioleiomyoma: a clinical, pathological and radiological review

Idiopathic Cystitis in Domestic Cats—Beyond the Lower Urinary Tract

Lateral Femoral Cutaneous Nerve Angiomyoma

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