Mast Cell Activation Syndrome and Gut Dysfunction: Diagnosis and Management

Hamilton, Matthew J.

doi:10.1007/s11894-024-00924-w

Cited by 1 publication

(1 citation statement)

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“…Mast cell numbers were found to be directly proportional to the severity of symptoms in IBS and it is thought that mast cell mediators may cause symptoms. The rise in the count of mast cells in the colon is one of the most consistent changes observed in IBS[ 34 ]. In addition, the severity of pain observed in patients with IBS is associated with the number of mast cells located close to enteric nerves.…”

Section: Clinical Symptoms and Signs In Different Organs And Systems ...mentioning

confidence: 99%

Mast cell activation syndrome: An up-to-date review of literature

Özdemir,

Kasımoğlu,

Bak

et al. 2024

World J Clin Pediatr

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Mast cells are a subtype of white blood cells and are involved in the immune system. These cells contain many chemical substances called mediators, which are involved in the allergic response. The fact that mast cells play a role in many events that require urgent intervention, especially anaphylaxis, has led to a more detailed study of these cells. The diseases also caused by dysfunctions of mast cells have been examined in many circumstances. For instance, mast cell activation syndrome is known as an augmented number of cells due to decreased cell death, resulting in clinical symptoms affecting many systems. The main common symptoms include flushing, hypotension, urticaria, angioedema, headache, vomiting and diarrhea. Although the underlying mechanism is not yet clearly known, we aim to review the literature in a broad perspective and bring together the existing knowledge in the light of the literature due to the diversity of its involvement in the body and the fact that it is a little known syndrome.

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Section: Clinical Symptoms and Signs In Different Organs And Systems ...mentioning

confidence: 99%