Massively parallel functional photoacoustic computed tomography of the human brain

Na, Shuai; Russin, Jonathan J.; Lin, Li; Yuan, Xiaoyun; Hu, Peng; Jann, Kay; Yan, Lirong; Maslov, Konstantin; Shi, Junhui; Wang, Danny J.J.; Liu, Charles Y.; Wang, Lihong V.

doi:10.1038/s41551-021-00735-8

Cited by 113 publications

(85 citation statements)

References 45 publications

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“…[38][39][40][41][42] It can also provide multi-scale imaging capability to balance the spatial resolution and penetration depth, which has a depth-to-resolutionratio of over 200. [38,42] In addition, PAI can be easily integrated into existing ultrasonographic platforms for clinical translation and has been extensively used in clinic, such as breast cancer screening, [43,44] brain investigation, [44,45] ovarian cancer detection via endoscopic mode, [46,47] and diagnosis of early-stage arthritis. [48,49] In this study, to achieve all-in-one anti-cancer strategy, we explore the possibility of drug delivery, cancer treatment and postoperative evaluation using the same mechanism and platform, referred to as all-in-one photoacoustic theranostics.…”

Section: Introductionmentioning

confidence: 99%

All‐in‐One Photoacoustic Theranostics Using Multi‐Functional Nanoparticles

Guo

Liu

et al. 2021

Adv Funct Materials

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Both treatment and postoperative evaluation of cancer play vital roles in improving the survival rate of patients. However, existing cancer therapies face multiple challenges of low drug delivery efficiency, separation of treatment and evaluation, and lack of noninvasive, routine and cost-efficient postoperative monitoring methods. To overcome these issues, an all-in-one anti-cancer strategy is proposed by using the combination of the photoacoustic (PA) effect and polymer nanoparticles. This strategy shows enhanced nanoparticles delivery, significant tumor ablation, and the capability of non-invasive and longitudinal postoperative evaluation. Near-infrared (NIR) excited photoacoustic radiation force (PAF) based on the high optical absorption nanoparticles opens the vascular barrier, accumulates the nanoparticles inside the tumor, and enables visualization of real-time nanoparticles distribution. Instead of conventional thermal therapy by using a continuous wave laser, the NIR pulsed laser coupled with PAF offers thermal therapy with further positive accumulation of nanoparticles, and significantly improves the treatment efficiency in return. In addition, the endogenous hemoglobin enables PA imaging to evaluate the efficacy of tumor therapy and monitor the progress of postoperative tumors in vivo through structural and functional parameters of the vascular network. This study presents a new opportunity for formulation of personalized and accurate tumor therapy, and timely feedback of therapeutic effect.

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Section: Introductionmentioning

confidence: 99%

All‐in‐One Photoacoustic Theranostics Using Multi‐Functional Nanoparticles

Guo

Liu

et al. 2021

Adv Funct Materials

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“…Such work shows the detailed angiographic structure of the human breast using photoacoustic computed tomography (PACT) scanning technology, and this imaging modality could also show tumors in the breast. Furthermore, PACT modality could not only be applied to diagnose human soft tissue diseases but also to detect the functional activity in the human brain ( Na et al. 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Noninvasive Dual-Modality Photoacoustic-Ultrasonic Imaging to Detect Mammalian Embryo Abnormalities after Prenatal Exposure to Methylmercury Chloride (MMC): A Mouse Study

Qiu

Huang

Zhang

et al. 2022

Environ Health Perspect

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“…In vivo OA imaging in non-human primates has been demonstrated ( 92 ) and in the neonatal brain ( 93 ). A recent OA/functional MRI study of the living adult human brain demonstrated the potential of its application in the clinical neuroimaging ( 94 , 95 ). However, significant challenges in skull aberrations and acoustic distortions still need to be addressed for potential clinical application and to further close the translational gap.…”

Section: Hybrid Imagingmentioning

confidence: 99%

Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics

Ren

Guan

et al. 2022

Front. Med.

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Small animal models play a fundamental role in brain research by deepening the understanding of the physiological functions and mechanisms underlying brain disorders and are thus essential in the development of therapeutic and diagnostic imaging tracers targeting the central nervous system. Advances in structural, functional, and molecular imaging using MRI, PET, fluorescence imaging, and optoacoustic imaging have enabled the interrogation of the rodent brain across a large temporal and spatial resolution scale in a non-invasively manner. However, there are still several major gaps in translating from preclinical brain imaging to the clinical setting. The hindering factors include the following: (1) intrinsic differences between biological species regarding brain size, cell type, protein expression level, and metabolism level and (2) imaging technical barriers regarding the interpretation of image contrast and limited spatiotemporal resolution. To mitigate these factors, single-cell transcriptomics and measures to identify the cellular source of PET tracers have been developed. Meanwhile, hybrid imaging techniques that provide highly complementary anatomical and molecular information are emerging. Furthermore, deep learning-based image analysis has been developed to enhance the quantification and optimization of the imaging protocol. In this mini-review, we summarize the recent developments in small animal neuroimaging toward improved translational power, with a focus on technical improvement including hybrid imaging, data processing, transcriptomics, awake animal imaging, and on-chip pharmacokinetics. We also discuss outstanding challenges in standardization and considerations toward increasing translational power and propose future outlooks.

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Massively parallel functional photoacoustic computed tomography of the human brain

Cited by 113 publications

References 45 publications

All‐in‐One Photoacoustic Theranostics Using Multi‐Functional Nanoparticles

All‐in‐One Photoacoustic Theranostics Using Multi‐Functional Nanoparticles

Noninvasive Dual-Modality Photoacoustic-Ultrasonic Imaging to Detect Mammalian Embryo Abnormalities after Prenatal Exposure to Methylmercury Chloride (MMC): A Mouse Study

Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics

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