Massive Weight Loss Obtained by Bariatric Surgery Affects Semen Quality in Morbid Male Obesity: a Preliminary Prospective Double-Armed Study

Samavat, Jinous; Cantini, Giulia; Lotti, Francesco; Franco, A. Di; Tamburrino, Lara; Degl'Innocenti, S; Maseroli, Elisa; Filimberti, E.; Facchiano, Enrico; Lucchese, Marcello; Muratori, Monica; Forti, Gianni; Baldi, Elisabetta; Maggi, Mario; Luconi, Michaela

doi:10.1007/s11695-017-2802-7

Cited by 73 publications

(63 citation statements)

References 36 publications

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“…El Bardisi et al was able to demonstrate improvement in sperm concentration in those that were oligospermic or azoospermic prior to sleeve gastrectomy (P<0.05) along with significant increases in serum testosterone (P<0.001) ( 92 ). In a prospective double-armed study comparing semen parameters in men undergoing gastric bypass versus non-operative management, Samavat et al demonstrated improvements in progressive/total sperm motility and number; however only semen volume and viability were found to have sustained significant improvements (P<0.05) after surgery ( 93 ).…”

Section: Future Considerationsmentioning

confidence: 99%

Frontiers in hormone therapy for male infertility

Khourdaji¹,

Lee²,

Smith³

2018

Transl. Androl. Urol.

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For a significant number of couples worldwide, infertility is a harsh reality. As specialists in male infertility, much of our armamentarium lacks definitive, evidence-based therapies. For years, we have relied on manipulation of the male hormonal axis to treat those men who help carry the burden of infertility in their partnerships. Indeed, male factor infertility is the sole component of infertility in at least 20% of couples. Further compounding this dilemma is that 25% to 50% of males with infertility have no identifiable etiology and thus present a true management conundrum. This manuscript is an attempt to clarify what therapies exist for the treatment of male factor infertility. We have reviewed the relevant infertility literature honing, our focus on hormonal anomalies and their subsequent impact on fertility. Many of the therapies discussed have been utilized in practice for generations. Thus, this article attempts to provide the evidence-based literature to support the continued use of the current treatment paradigm. Furthermore, we recognize that any review beckons a discussion of what challenges and therapies await on the horizon. For instance, there has been significant interest in restoring spermatogenesis after testosterone replacement therapy (TRT). We explore the adverse long-term spermatogenic outcomes associated with TRT, which with the widespread use of TRT, will inevitably present a great challenge for male infertility specialists. Moreover, we discuss the role of varicocelectomy in the treatment of hypogonadism and infertility, review the association between growth hormone (GH) and male fertility and address the challenges presented by the rising prevalence of obesity.

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Section: Future Considerationsmentioning

confidence: 99%

Frontiers in hormone therapy for male infertility

Khourdaji¹,

Lee²,

Smith³

2018

Transl. Androl. Urol.

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“…Three studies were included in our study [8][9][10]. The searching process is summarized in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…They found the changes of BMI was associated with in sperm volume (r=0.618, p<0.05) with statically significant. MacDonald et al performed a cross-sectional study recruit 514 men suggested that the sperm volume (r=0.02, p>0.05) [8].…”

Section: Discussionmentioning

confidence: 99%

Effect of Bariatric Surgery on Obese Male Semen Parameters and Reproductive Hormones: a meta-analysis

Jiang

Qian

Ye³

2019

Preprint

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Background The relation between bariatric surgery and semen parameters and reproductive hormones on obese male remains incompletely understood.Methods We searched PUBMED, EMBASE and the Cochrane Central Register for studies from 1999 to 2019 for studies on effect of bariatric surgery on obese male semen parameters and reproductive hormones. Three studies met the inclusion criteria for our meta-analysis. After data extraction and quality assessment, we used RevMan 5.2 to pool the data.Results Three studies were included in our meta-analysis. The pooled data showed that the testosterone concentration and sperm volume were higher in postoperative group than baseline with a significant difference (WMD:4.63, 95%CI 2.65 to 6.61, P<0.05, WMD; 0.89, 95CI 0.38 to 1.40, P<0.05, respectively). No significant difference was found in the postoperative sperm concentration, sperm morphology, sperm motility and estradiol concentration (WMD: -3.28, 95%CI: -38.86 to 32.29, I2=9%; p=0.89,WMD: -0.52, 95%CI: -5.83 to 4.79, I2=71%; p=0.85, (WMD; -0.01, 95%CI; -5.42 to 5.40, I2=0; p=1.00, WMD: -2.93, 95%CI: -43.11 to 37.24, I2=87%; p=0.89, respectively).Conclusions Bariatric surgery did not interfere with sperm quality. Our study showed that the postoperation testosterone increased with statistically significance.

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“…11 Paternal obesity is also acknowledged to negatively affect assisted reproduction outcomes. 12 However, results are conflicting regarding the effect of significant weight loss on semen analysis parameters because 'improved', [13][14][15][16][17] 'no change' 18 and 'deterioration' 19,20 have all been reported.…”

Section: Obesity and Weight Lossmentioning

confidence: 99%

An update on the management of male infertility

Karavolos

Panagiotopoulou²,

AlAhwany

et al. 2020

The Obstetric & Gynaecologis

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Male infertility underlies or contributes to up to 50% of infertility cases; current therapeutic interventions rely on assisted reproductive technology (ART), as medical or surgical treatments have limited value in enhancing semen quality or parameters. Lifestyle factors that affect male fertility could offer a therapeutic opportunity; however, their modification seems to be of variable benefit. In the quest for sperm functional assessment and selection tests, there is controversy over which patients, if any, should be tested for sperm DNA fragmentation, as well as which test to perform. Sperm selection techniques for intracytoplasmic sperm injection do not appear to significantly improve treatment outcomes or live birth rates. Routinely performed genetic tests are effective in determining aetiology in approximately 20% of infertile men; however, newer genetic tests could enhance diagnosis and change the future management of male infertility. Learning objectives To summarise the key lifestyle factors that affect male fertility. To appraise the currently available investigations for sperm testing and selection. To describe the genetic tests currently available to identify the aetiology of male infertility, including emerging technologies in the field of genetics and personalised genomics. Ethical issues How to deal with couples' requests for unproven medical interventions to manage male infertility?

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Massive Weight Loss Obtained by Bariatric Surgery Affects Semen Quality in Morbid Male Obesity: a Preliminary Prospective Double-Armed Study

Cited by 73 publications

References 36 publications

Frontiers in hormone therapy for male infertility

Frontiers in hormone therapy for male infertility

Effect of Bariatric Surgery on Obese Male Semen Parameters and Reproductive Hormones: a meta-analysis

An update on the management of male infertility

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