Massive Subretinal Hemorrhage with Acute Angle-Closure Glaucoma in Chronic Myelocytic Leukemia

Ocular Manifestations of Primary Myelofibrosis

“…Although the exact diagnoses in these cases differ from our patient, these diagnoses were myeloproliferative disorders of some sort. The anterior segment and retinal findings in our patient were highly likely due to neoplastic infiltration of the uveal tract in the patient, which is similar to the findings reported by Baillif et al 8 However, our patient differed from their findings, in that, our patient's systemic diagnosis was already established before his ocular signs and symptoms, and infiltration of the actual neoplasm may have been responsible for this patient's signs and symptoms. Cytologic analysis of his choroidal infiltrates, cerebrospinal fluid, and bone marrow biopsy did not show any conversion to leukemia, despite an unusually high leukocytes.…”

“…5 There have also been documented cases of metastatic leukemia and lymphoma presenting as narrow angle-closure glaucoma. [6][7][8][9][10] In these cases, presentations of bilateral, simultaneous angle-closure suggested a systemic disease, which was the case in our patient. Although the exact diagnoses in these cases differ from our patient, these diagnoses were myeloproliferative disorders of some sort.…”

Acute Angle-Closure Glaucoma from Spontaneous Massive Hemorrhagic Retinal Detachment

“… 6 However, in our case, preoperative examination failed to reveal macular degeneration in either eye and the ocular pathology specimen did not reveal the source of bleeding. Another report by Kozlowski et al 12 reported massive subretinal hemorrhage with acute angle-closure glaucoma in a case of chronic myleocytic leukemia. They suggested that ocular hemorrhage in leukemia might be related to the invasion of vessel walls by leukemic cells or abnormalities in blood clotting mechanisms.…”

Visual fields after removal of subretinal hemorrhages and neovascular membranes in age-related macular degeneration

“…The short-term consequences of such extensive bleeding are subtotal exudative retinal detachment and hemorrhagic infiltration of the vitreous body [6,27]. Angle closure glaucoma may occur [14, 15,27]. The long-term result in the natural course is total damage of the retinal pigment epithelium (RPE) [1].…”