Massive Splenomegaly and Pancytopenia: It’s a Hairy Situation

Clark, Sarah M.; Samareh-Jahani, Farmin; Chaudhuri, Munir A

doi:10.7759/cureus.12237

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…The accurate diagnosis of SMZL is delayed because it does not show remarkable clinical symptoms and aggressive clinical courses 1 . The causes of massive splenomegaly are leukemias, non‐Hodgkin lymphoma, myelofibrosis, metastatic cancer, primary splenic tumors, infection, autoimmune hemolytic anemia, β‐thalassemia major, megaloblastic anemia, hereditary spherocytosis, and infiltrative conditions 2 . When seeing massive splenomegaly, hematologic malignant diseases should be ruled out first.…”

Section: Casementioning

confidence: 99%

Massive splenomegaly requiring differential diagnosis of hematologic malignancies

Tago

Nakashima

et al. 2022

Clinical Case Reports

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Section: Casementioning

confidence: 99%

Massive splenomegaly requiring differential diagnosis of hematologic malignancies

Tago

Nakashima

et al. 2022

Clinical Case Reports

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Section: Introductionmentioning

confidence: 97%

“…Given this backdrop, this case report emerges as a rare and valuable contribution to the medical literature, given its unusual combination of extrahepatic SAA etiology, pancytopenia, and massive splenomegaly [ 10 ]. It is a poignant reminder of the critical significance of timely diagnosis and intervention in managing these intricate and life-threatening cases.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Splenic Artery Aneurysm With Unusual Combination of Pancytopenia and Massive Splenomegaly in a Tertiary Care Hospital

Kulkarni,

Chakole,

Dubey

et al. 2023

Cureus

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Aneurysms of the splenic artery leading to extrahepatic portal hypertension are sporadic and infrequently encountered. They typically manifest as a consequence of thrombus or embolus formation. A splenic artery aneurysm (SAA) represents a localized expansion in the diameter of the splenic artery and is one of the most prevalent forms of visceral artery aneurysms. This artery dilation is primarily attributed to pancreatitis, trauma, or atherosclerosis, commonly affecting elderly patients. Patients affected by this condition typically remain asymptomatic, except for an audible bruit over the aneurysm site, unless a rupture occurs. In the event of a rupture, early indicators include abdominal pain, hemoperitoneum, and a positive Kerr sign, all indicative of SAA rupture. Most SAAs are incidentally discovered, with CT angiography being the preferred diagnostic tool. We present the case of a 38-year-old female (gravida 1, para 1) with a previous full-term normal delivery, who presented to a rural tertiary care hospital with a two-week history of left-sided abdominal pain. A CT scan of the abdomen revealed a solitary aneurysm in the distal portion of the splenic artery, accompanied by perisplenic fluid collection resulting in splenomegaly. Given the critical risk of rupture, which can result in life-threatening bleeding, prompt and accurate diagnosis assumes paramount significance. It is worth noting that the diagnosis of SAA often occurs incidentally due to its asymptomatic nature in its early stages. We document this unique occurrence of extrahepatic SAA contributing to pancytopenia, portal hypertension, and extensive splenomegaly to provide valuable insights for medical professionals in recognizing and managing such presentations. This awareness can help prevent unnecessary diagnostic and therapeutic interventions.

show abstract

Massive Splenomegaly and Pancytopenia: It’s a Hairy Situation

Cited by 2 publications

References 17 publications

Massive splenomegaly requiring differential diagnosis of hematologic malignancies

Massive splenomegaly requiring differential diagnosis of hematologic malignancies

A Rare Case of Splenic Artery Aneurysm With Unusual Combination of Pancytopenia and Massive Splenomegaly in a Tertiary Care Hospital

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