“…In a 2016 evidence synthesis report by Agency of Healthcare Research and Policy, the authors reported the overall rate of major bleeding of 0.8 per 1,000 procedures (n Z 3,347,101, 95% CI, 0.5–1.4) and the perforation rate of 0.4 per 1,000 procedures (95% CI, 0.2–0.5) for screening colonoscopy [ 3 ]. Globally, most studies of AEs of this procedure are conducted in the West and relatively few studies have been conducted in the East [ 4 , 6 ].…”