Massive pulmonary haemorrhage in the newborn: A changing pattern

Pulmonary haemorrhage in preterm infants

“…Our data show that patients receiving CBZ and VPA monotherapy can have abnormal sex hormone levels. In particular, in CBZ treated patients we observed a decrease in FT and DHEAS and an increase in SHBG; our ®nding of high serum SHBG levels in CBZ treated patients in accordance with previous reports [1,2]. It is well known that SHBG is synthesised in the liver and that CBZ is an eective inducer of the liver microsomal enzyme system; therefore, liver enzyme inducing drugs probably increase the amount of circulating SHBG by directly inducing its synthesis in the liver.…”

“…Early uncontrolled studies suggested that PH was associated with several predisposing factors, mainly in mature babies [1]. In contrast, PH is now more often described as a complication of preterm infants with respiratory distress syndrome who have received surfactant replacement therapy.…”

Die Thoraxerkrankungen des Neugeborenen

“…Die pulmonale Blutung macht röntgenmorphologisch kein pathognomonisches Muster (BooTHBY u. DE SA 1973;PONHOLD 1981 b). Sie kann als alveoläre, interstitielle oder als gemischt alveolo-interstitielle Verdichtung imponieren.…”

Survival After Pulmonary Haemorrhage in Idiopathic Respiratory Distress Syndrome of the Newborn

“…High inspired oxygen partial pressures are known to cause pulmonary damage, with capillary proliferation and exudation into the alveoli (Pratt, 1958(Pratt, , 1965Kistler, Caldwell and Weibel, 1967;Nash, Blennerhassett and Pontoppidan, 1967;Robinson et al, 1967). Oxygen toxidty has been suggested as a cause of pulmonary haemorrhage in neonates by Shanklin and Wolfson (1967) and Boothby and DeSa (1973) and incriminated in the aetiology of bronchopulmonary dysplasia, a condition which includes alveolar necrosis and pulmonary fibrosis (Northway, Rosan and Porter, 1967;Hawker, Reynolds and Taghizadeh, 1967).…”