Massive Immune Hemolysis Caused by Anti‐D After Dual Kidney Transplantation

Donors With Immune Thrombocytopenia: Do They Pose a Risk to Transplant Recipients?

“…GVHD after liver transplantation has been reported in 0.1-2% of liver transplant recipients and may progress to a fatal multisystem disease (1)(2)(3). Donor plasma cells or B-lymphocytes transmitted with an allograft have also been reported to cause transient hemolysis when donor-specific antibodies react against recipient red cells (the passenger lymphocyte syndrome [PLS]) (4,5). In addition to GVHD and PLS, there have been occasional case reports documenting the transmission of immune thrombocytopenia (ITP) from organ donors to liver transplant recipients with serious consequences (6)(7)(8)(9)(10).…”

A ‘Dangerous’ Group O Donor: Severe Hemolysis in All Recipients of Organs from a Donor with Multiple Red Cell Alloantibodies

“…Hemolysis due to PLS appears to be less common following solid organ transplant (1,2), and the relative frequency of PLS appears to be related to the volume of transplanted lymphoid tissue. PLS usually results from antibodies active within the ABO and Rh systems (5–9). Rarely, it may occur due to non‐ABO/Rh antibodies, particularly if the organ donor has been previously sensitized to other red cell (RC) antigens by transfusion or pregnancy (5,9,10).…”

Passenger lymphocyte syndrome in ABO and Rhesus D minor mismatched liver and kidney transplantation: A prospective analysis

“…Our report and others suggest that severe anemia is the most significant acute complication of PLS [34]. Clinical outcomes of PLS are good; however, cases of graft failure have been reported [13].…”