Massive Hyperstimulation and Borderline Carcinoma of the Ovary

Atlas, Michel; Menczer, Joseph

doi:10.3109/00016348209156568

Cited by 61 publications

(15 citation statements)

References 17 publications

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“…Only one patient (case #4) had been treated with an unusual medication, clomiphene citrate. Although this drug has anecdotally been associated with testicular [20] and ovarian [21] neoplasms, we are unaware of any association between clomiphene citrate and Hodgkin's disease. Several authors have suggested that hematologic malignancies are rare in patients with sickle hemoglobinopathy [1,3,11].…”

Section: Discussionmentioning

confidence: 99%

Hematologic malignancy in sickle cell disease: Report of four cases and review of the literature

et al. 1986

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Hematologic malignancy has rarely been reported in adults with sickle cell disease. We describe four sickle cell patients (two with hemoglobin SC, two with hemoglobin SS) who developed hematologic malignancy (acute myeloblastic leukemia, multiple myeloma, malignant histiocytosis, and Hodgkin's disease). Three of the cases represent the first adult association between SC or SS hemoglobinopathy and the particular malignancy involved. Sickle hemoglobin does not appear to exert a protective effect against childhood hematologic malignancies, suggesting that better survival in sickle cell disease may be accompanied by an increased incidence of hematologic neoplasms in adulthood. Karyotypic analysis revealed alterations of chromosome 5 in two sickle cell patients with leukemia, raising the possibility of a chromosomal link between the two diseases. Further epidemiologic and cytogenetic studies are needed to define the relationship between hematologic malignancy and sickle cell disease.

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Section: Discussionmentioning

confidence: 99%

Hematologic malignancy in sickle cell disease: Report of four cases and review of the literature

et al. 1986

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“…The risk of malignancy appears to be low (Lais et al, 1988); a recent study using transvaginal ultrasonography to predict ovarian malignancy demonstrated a sensitivity of 100% and a negative predictive value of 100% (Sassone et al, 1991), and 60.6% of the cysticsepta tumours measuring 30-80 mm in diameter identified by echography resolve spontaneously within 3 months (Pinotti et al, 1988). However, it should be emphasized that persistent enlarged/ hyperstimulated ovaries in patients treated with follicular stimulants may mask ovarian neoplasm and result in a delay of the correct diagnosis (Atlas and Menczer, 1982;Bamford and Steele, 1982;Ben-Hur et al, 1986;Carter and Joyce, 1987). In the case presented here, the 'follicular structure' of the tumour which looked like a hyperstimulated ovary, could make ultrasonic diagnosis much more difficult.…”

Section: Discussionmentioning

confidence: 79%

Infertility: Metastatic ovarian strumosis in an in-vitro fertilization patient

et al. 1993

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Malignant struma ovarii is a very rare tumour, with considerable controversy concerning the necessary histologic features for malignancy. Still more infrequent is the condition termed 'metastatic ovarian strumosis' or simply 'benign strumosis or strumatosis' and characterized by the presence of peritoneal implants of mature thyroid tissue occurring in struma ovarii. 'Strumosis' should not be confused with malignancy. Presented is a case of 'metastatic ovarian strumosis' in a 36-year-old woman with primary infertility who underwent three in-vitro fertilization (IVF) cycles with ovarian stimulation. She received hormonal treatment for 6 months after her last IVF because of 'persistent enlarged ovarian follicles' which were in fact 'thyroid follicles'.

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“…Can ovarian stimulation or IVF be proposed to these patients when several studies incriminate hyperstimulation in the onset of ovarian cancer and borderline tumors? (3)(4)(5) This attitude is debated because the link between ovarian stimulation and the risk of ovarian cancer remains unclear.…”

Section: Discussionmentioning

confidence: 98%