MASSIVE HEPATIC NECROSIS following general anesthesia*

Temple, Robert; Côté, Roger A.; Gorens, Sherwood W.

doi:10.1213/00000539-196209000-00016

Cited by 30 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The importance of hypoxia in the aetiology of liver damage has been recognized for many years (Martin, Loevenhart and Bunting, 1918;Bourne, 1936;Popper, 1954;Refsum, 1963). Despite this, in the recent series of case reports of patients who became jaundiced following halothane anaesthesia, little or no consideration was given to this factor, although in several cases there was strong circumstantial evidence of hypoxia (Burnap, Galla and Vandam, 1958;Temple, Cote and Gorens, 1962;Slater et al, 1964). The recent advances in the techniques of measuring arterial oxygen tension and their wider availability open the way to an increasing appreciation of changes in oxygenation occurring during anaesthesia.…”

Section: The Resultsmentioning

confidence: 99%

A Prospective Study of Changes in Liver Function After Operation Under Two Forms of General Anaesthesia

Dodson

Richards

1972

British Journal of Anaesthesia

View full text Add to dashboard Cite

Although not ideal, this test offered the advantages not only of increased sensitivity, but also of supplying a considerable amount of information about the processes involved in the removal of b.s.p. from the plasma and its excretion into bile. It was realized that much work had already been carried out in the field of postanaesthetic liver function changes and excellent reviews have been compiled by Johnstone (1964) and Little and Wetstone (1964) amongst others. These reviews, and many of the articles to which they refer, gave the impression that there is a minimal and inevitable degree of liver dysfunction after any general anaesthetic. The establishment of such a "baseline" or "inevitable" change in function would be the criterion by which significant change would be measured. This study was designed with the purpose of establishing the "baseline", and of trying to correlate postoperative changes in liver function with some of the many factors associated with the performance of an operation under a general anaesthetic, including the use of halothane. METHODS An initial pilot study, not described here, was used as a guide to the methodology which was adopted for this reported study.

show abstract

Section: The Resultsmentioning

confidence: 99%

A Prospective Study of Changes in Liver Function After Operation Under Two Forms of General Anaesthesia

Dodson

Richards

1972

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…A recent post-operative death from toxic hepatitis led to a search into the background, when 11 deaths following halothane anaesthesia were found reported in the literature (Burnap et al, 1958 ;Virtue and Payne, 1958;Vourc'h et al, 1960;Temple et al, 1962;Brody and Sweet, 1963;Lindenbaum and Leifer, 1963;Bunker and Blumenfeld, 1963). It is difficult to assess scattered reports, and so this case is presented to add to the collective series, in the hope that when other such misfortunes occur they may be reported.…”

Section: Preliminary Communications Liver Damage After Halothane Anaementioning

confidence: 99%

Liver Damage After Halothane Anaesthesia

Chamberlain¹

1964

Survey of Anesthesiology

View full text Add to dashboard Cite

“…Halothane is regarded as a powerful and safe inhalant anaesthetic agent, and since 1956 it has been used millions of times. A recent post-operative death from toxic hepatitis led to a search into the background, when 11 deaths following halothane anaesthesia were found reported in the literature (Burnap et al, 1958 ;Virtue and Payne, 1958;Vourc'h et al, 1960;Temple et al, 1962;Brody and Sweet, 1963;Lindenbaum and Leifer, 1963;Bunker and Blumenfeld, 1963). It is difficult to assess scattered reports, and so this case is presented to add to the collective series, in the hope that when other such misfortunes occur they may be reported.…”

Section: Preliminary Communications Liver Damage After Halothane Anaementioning

confidence: 99%

Liver Damage after Halothane Anaesthesia

Chamberlain¹

1963

BMJ

View full text Add to dashboard Cite

NEW ORAL DIURETIC BRITISH those patients who have not responded to other diuretics. Summary A new diuretic drug, ethacrynic acid (MK-595), has been compared with hydrochlorothiazide in normal volunteers and oedematous patients. Structurally the two drugs are not related. Ethacrynic acid is a potent diuretic causing an excretion pattern similar to that caused by hydrochlorothiazide. It produced in oedematous patients a greater diuresis than hydrochlorothiazide, each at a dose of 50 mg. thrice daily, but the potassium loss was correspondingly greater. One patient who was resistant to hydrochlorothiazide had an adequate diuresis with ethacrynic acid. Acute gout was induced by ethacrynic acid in one patient; no other side-effects were noted. We are indebted to Dr. K. C. Mezey, of Merck Sharp and Dohme, Research Laboratories, Rahway, New Jersey, for supplies of MK-595 and for an investigational grant-in-aid. The Auckland Medical Research Foundation provided financial support for a biochemist. We wish to express our thanks to Mr.

show abstract

MASSIVE HEPATIC NECROSIS following general anesthesia*

Cited by 30 publications

References 0 publications

A Prospective Study of Changes in Liver Function After Operation Under Two Forms of General Anaesthesia

A Prospective Study of Changes in Liver Function After Operation Under Two Forms of General Anaesthesia

Liver Damage After Halothane Anaesthesia

Liver Damage after Halothane Anaesthesia

Contact Info

Product

Resources

About