Massive hemorrhage and infarction complicating focal nodular hyperplasia of the liver

Bathe, O F; Mies, Carolyn; Franceschi, Dido; Casillas, Javier; As, Livingstone

doi:10.1080/13651820310000

Cited by 14 publications

(1 citation statement)

References 26 publications

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“…Size of the lesion might be related with greater risk of rupture and compressive effects upon adjacent structures (Table 1). 24,[42][43][44][45][46][47][49][50][51][53][54][55][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76] Management with surgical resection, transarterial embolization or radiofrequency ablation should be considered in patients experiencing severe pain with no other identifiable cause or large or rapidly growing lesions with risk of causing complications.…”

Section: Discussionmentioning

confidence: 99%

Focal Nodular Hyperplasia: A Comprehensive Review with a Particular Focus on Pathogenesis and Complications

Villavicencio Kim,

2023

J Clin Transl Hepatol

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Focal nodular hyperplasia is a benign tumor of the liver that is often found incidentally with imaging. The purpose of this review is to discuss the pathophysiology, rare complications that can occur due to these lesions, and management options. A literature review was performed on clinical trials and case reports involving focal nodular hyperplasia complications and management of these, as well as the proposed pathogenesis underlying these tumors. Although exposure to oral contraceptive pills and endogenous hormones have been thought to play a role in the development of these lesions, this has not been proven. Most recently, they are thought to arise as a consequence of a vascular anomaly causing alterations in the expression of angiopoietin genes. Complications are rare, but previous cases have reported associated pain, rupture and compression of nearby structures (hepatic vein, stomach, biliary system). Resection of focal nodular hyperplasia is not usually recommended. However, if there is associated pain with no other identifiable cause or presence of a large or growing lesion with risk of causing a complication, then surgical resection, radiofrequency ablation or arterial embolization should be considered.

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