Massive-Dose Rapid Palliative Radiotherapy

Horrigan, W.; Atkins, Harold L.; Tapley, Norah duV.

doi:10.1148/78.3.439

Cited by 9 publications

(2 citation statements)

References 4 publications

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“…QUAD Shot is a form of hypofractionated radiotherapy that is used in many malignancies, including pelvic and head/neck cancers. 11,12 The first published report of hypofractionated radiotherapy used for palliation was in 1959 for patients with breast cancer 13 (Table 2). These patients received 12.5 Gy per day for two days.…”

Section: Commentmentioning

confidence: 99%

The Use of “QUAD Shot” in Anal Canal Squamous Cell Carcinoma: A Case Study With Review of the Literature

Chevli

Lewis

Swanson

2019

Journal of Pain and Symptom Management

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Context. Patients with locoregional anal carcinoma who do not qualify for standard definitive chemoradiation are candidates for a short course of palliative hypofractionated radiotherapy such as QUAD Shot. Methods. A 57-year-old man with massive locoregional squamous cell carcinoma of the anal canal was treated with QUAD Shot (14.8 Gy in four fractions over two consecutive days) repeated every four weeks for a total of two courses. Results. He reported symptomatic relief following each course of radiation. In regard to his first QUAD Shot, his pain was 10/10 in severity at the time of admission and 4/10 at the time of discharge. In regard to his second QUAD Shot, his pain was 8/10 at the time of admission and 0/10 at the time of discharge. He did not experience any treatment-related toxicity. He passed away 15 weeks after the first course. Conclusion. QUAD Shot is both efficacious and safe for palliation in patients with anal carcinoma.

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Section: Commentmentioning

confidence: 99%

The Use of “QUAD Shot” in Anal Canal Squamous Cell Carcinoma: A Case Study With Review of the Literature

Chevli

Lewis

Swanson

2019

Journal of Pain and Symptom Management

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“…consisting of two sessions of 6.5 or 8. 5 Gy at 48-hr we Used the linear mxlerator with a 25 MV Photon intervals for tumors affecting the oesophagus, brain, beam to achieve a relatively low integral dose with a bones, and mediastinurn with significant advantages and Skin-Sparing effect, homogeneous distribution Of radiaon cell models showed that the equivalent of 13 G~ in 48 The technique consisted of two anterior-posterior pelh was similar to 25 Gy in 16 days and 17 GY in 48 h was vic p O d S of about 15 X 15 cm; the dose was expressed daily at the mid-plane and consisted of two fractions of 6.5 Gy fractionation.…”

Section: Introductionmentioning

confidence: 99%

Haemostatic and antialgic effects of the 25 mv photon beam concentrated dose in the treatment of carcinoma of the cervix

Patrício¹,

Tavares²,

Guimarães³

et al. 1987

Journal of Surgical Oncology

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The authors present the results of a preliminary study on the use of a concentrated dose of 13 Gy in 48 hours in the treatment of cancer of the cervix, especially for haemostatic and antialgic purposes and mostly as a first part of a split course of radiotherapy. In 13 patients with early stages of the disease, the method was used as an emergency treatment with good response in 84.6% of the cases without serious complications. In 43 patients with advanced disease, the concentrated dose was generally repeated for palliation and relieved symptoms in about 72% of the cases but with complications in 16.3%. The authors recommend this method only when absolutely necessary to stop severe haemorrhage and suggest that patients with good response to the first flash course should continue treatment with conventional fractionation, bearing in mind the tolerance of the normal tissues.

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A Brief History of Palliative Radiation Oncology

Jones

2013

Radiation Oncology in Palliative Cancer Care

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Massive-Dose Rapid Palliative Radiotherapy

Cited by 9 publications

References 4 publications

The Use of “QUAD Shot” in Anal Canal Squamous Cell Carcinoma: A Case Study With Review of the Literature

The Use of “QUAD Shot” in Anal Canal Squamous Cell Carcinoma: A Case Study With Review of the Literature

Haemostatic and antialgic effects of the 25 mv photon beam concentrated dose in the treatment of carcinoma of the cervix

A Brief History of Palliative Radiation Oncology

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