Massive copper and selenium losses cause life-threatening deficiencies during prolonged continuous renal replacement

Ben-Hamouda, Nawfel; Charrière, M.; Voirol, Pierre; Berger, Mette M.

doi:10.1016/j.nut.2016.09.012

Cited by 52 publications

(50 citation statements)

References 22 publications

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“…The data reported in our study suggest a high incidence of copper deficiency in critically ill patients requiring CRRT, which may be due in part to prolonged duration of CRRT in our sample. Based on previous reports and our study results, the supplementation of copper during CRRT with serial blood levels to ensure adequate supplementation may be prudent.…”

Section: Discussionmentioning

confidence: 61%

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Micronutrient Alterations During Continuous Renal Replacement Therapy in Critically Ill Adults: A Retrospective Study

et al. 2017

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Section: Discussionmentioning

confidence: 61%

“…Copper is essential for wound healing and immune function, as well as a critical cofactor for numerous cuproenzymes throughout the body, including that in the mitochondrial electron transport chain . Copper deficiency can cause leukopenia, neutropenia, bone demineralization, and compromised immune function .…”

Section: Discussionmentioning

confidence: 99%

Micronutrient Alterations During Continuous Renal Replacement Therapy in Critically Ill Adults: A Retrospective Study

et al. 2017

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“…Nevertheless, in case of CRRT exceeding 2 weeks in major burns, the additional high risk of Cu depletion due to prolonged effluent losses requires weekly Cu blood monitoring . Copper deficiency, in the presence of inflammation where increased levels are normally found, requires immediate IV corrective action …”

Section: Q5: Which Intravenous Micronutrients Are Necessary In Patienmentioning

confidence: 99%

Parenteral Provision of Micronutrients to Adult Patients: An Expert Consensus Paper

Blaauw

Osland

Sriram

et al. 2019

J Parenter Enteral Nutr

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Background Micronutrients, an umbrella term used to collectively describe vitamins and trace elements, are essential components of nutrition. Those requiring alternative forms of nutrition support are dependent on the prescribed nutrition regimen for their micronutrient provision. The purpose of this paper is to assist clinicians to bridge the gap between the available guidelines’ recommendations and their practical application in the provision of micronutrients via the parenteral route to adult patients. Methods Based on the available evidenced‐based literature and existing guidelines, a panel of multidisciplinary healthcare professionals with significant experience in the provision of parenteral nutrition (PN) and intravenous micronutrients developed this international consensus paper. Results The paper addresses 14 clinically relevant questions regarding the importance and use of micronutrients in various clinical conditions. Practical orientation on how micronutrients should be prescribed, administered, and monitored is provided. Conclusion Micronutrients are a critical component to nutrition provision and PN provided without them pose a considerable risk to nutrition status. Obstacles to their daily provision—including voluntary omission, partial provision, and supply issues—must be overcome to allow safe and responsible nutrition practice.

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“…Dextrose equivalents present in nutritive sweeteners . The different carbohydrates used as sweeteners in enteral formulas can be classified by the amount of dextrose equivalents.…”

Section: Carbohydrates Good and Badmentioning

confidence: 99%

“…According to Berger, patients with major trauma and burns can benefit from micronutrients supplemented by parenteral infusion. Enteral feeding formulas may not contain sufficient micronutrients to compensate patient losses or are poorly absorbed during the early phase of injury …”

Section: Vitamins and Minerals: Just The Recommended Daily Intake?mentioning

confidence: 99%

Knowledge of Constituent Ingredients in Enteral Nutrition Formulas Can Make a Difference in Patient Response to Enteral Feeding

Savino¹

2017

Nut in Clin Prac

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Enteral feeding is considered the preferred method for providing a complete or supplemental source of nutrition to patients. Enteral formulas (EFs) are traditionally assessed from general information provided by the manufacturer such as caloric density, percentage of macronutrients, and micronutrients to meet the Recommended Dietary Allowance. Sometimes labeling information highlights particular ingredients to indicate specific properties at a metabolic or nutrition level. However, it is necessary to review the quality and composition of any enteral formula, since the basic components are responsible for tolerance and nutrition efficacy, and this should not be overshadowed by the benefit of a single constituent. Intolerance to EF is commonly attributed to individual patient response or to the means of administration. The objective of this review is to highlight the importance of appraising EFs with regard to composition and effect on the gastrointestinal tract. (Nutr Clin Pract. 2018;33:90-98)

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Massive copper and selenium losses cause life-threatening deficiencies during prolonged continuous renal replacement

Cited by 52 publications

References 22 publications

Micronutrient Alterations During Continuous Renal Replacement Therapy in Critically Ill Adults: A Retrospective Study

Micronutrient Alterations During Continuous Renal Replacement Therapy in Critically Ill Adults: A Retrospective Study

Parenteral Provision of Micronutrients to Adult Patients: An Expert Consensus Paper

Knowledge of Constituent Ingredients in Enteral Nutrition Formulas Can Make a Difference in Patient Response to Enteral Feeding

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